Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

NCT ID: NCT02151630

Last Updated: 2014-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2014-09-30

Brief Summary

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Plantar warts can be bothersome and painful requiring treatment. The investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. Patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. Patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. The number and size of warts will be evaluated.

Detailed Description

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Conditions

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Plantar Wart

Keywords

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wart verruca vulgaris topical therapy pyruvic acid salicylic acid

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Pyruvic acid

Patients will receive pyruvic acid solution 70% prepared by solving of pyruvic acid in water/ethanol solution. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Group Type ACTIVE_COMPARATOR

Pyruvic acid

Intervention Type DRUG

Salicylic acid

Patients will receive a combination of salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Group Type ACTIVE_COMPARATOR

Salicylic Acid

Intervention Type DRUG

Interventions

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Pyruvic acid

Intervention Type DRUG

Salicylic Acid

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* aged 12 years and above
* multiple warts (at least 2)

Exclusion Criteria

* mosaic warts
* already under any treatment for warts
* pregnant or lactating women
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Isfahan University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Fatima Assaf

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fatima Assaf, M.D.

Role: PRINCIPAL_INVESTIGATOR

Isfahan University of Medical Sciences

Locations

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Skin Diseases and Leishmaniasis Research Center

Isfahan, Isfahan, Iran

Site Status RECRUITING

Countries

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Iran

Central Contacts

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Fatima Assaf, M.D.

Role: CONTACT

Phone: 0098 913 0965384

Email: [email protected]

Facility Contacts

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Fatima Assaf, M.D.

Role: primary

References

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Kwok CS, Holland R, Gibbs S. Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials. Br J Dermatol. 2011 Aug;165(2):233-46. doi: 10.1111/j.1365-2133.2011.10218.x. Epub 2011 May 26.

Reference Type BACKGROUND
PMID: 21219294 (View on PubMed)

Other Identifiers

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393219

Identifier Type: -

Identifier Source: org_study_id