Brain Biomarkers w/Mind-Body Tx in Veterans With Post Traumatic Headache (PTH)

NCT ID: NCT02145117

Last Updated: 2017-12-07

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-09-30
• Study Completion Date: 2018-09-27

Brief Summary

This project aims to develop and test structural and functional brain imaging biomarkers for improvement in chronic pain from a mind/body intervention perspective in a critical veteran population, namely veterans with post traumatic headache (PTH) associated with mild traumatic brain injury (TBI). The project also aims to examine feasibility in a sample of veterans with PTH of performing resting state and structural neuroimaging protocols, and of obtaining active participation and completion of MBSR training. Lastly, exploratory analysis of brain imaging data will be performed to determine if hypothesized candidate biomarkers are associated with positive outcomes from MBSR and determine estimated effect sizes for future studies in PTH population.

Detailed Description

Returning veterans from Iraq and Afghanistan (OIF/OEF veterans) have a very high incidence of TBI (14-23%) with the largest number having mild TBI (i.e., no discernible structural brain damage) with 63.5% having persistent headache. Treatment of PTH in this population has been difficult and mind/body interventions including Mindfulness Based Stress Reduction (MBSR) may offer significant benefit. A biomarker that will support clinical endpoints ("surrogate endpoint") and help predict clinical benefit, could be used to more efficiently and completely assess mind/body treatment effects in clinical trials for PTH, compare various complementary and alternative medicine (CAM) treatments, and potentially target specific treatments to patients most likely to benefit. This project aims to investigate candidate biomarkers for MBSR response in veterans with PTH. Primarily, all subjects if they are interested and appropriate for the study, will undergo a screening at their regular clinic visit at the VAGLAS physical medicine and rehab department. If a subject responds to advertisement they will be screened using the same tools and enrollment criteria required for the veterans at VAGLAS. We expect we will need to enroll and screen no less than 33 subjects in order to complete 20 evaluable subjects for analysis. The study subjects will be evaluated for the severity of their PTH, the impact of PTH on their life, and the extent of the disease/pain condition. If eligible the nurse coordinator will contact them to schedule the pre-MBSR functional MRI visit. At the MRI we will evaluate patterns of activity (functional connectivity) in the brain at rest, and look at cortical thickness. Following the MRI visit all subjects will complete a 9-week modified MBSR training with a qualified instructor. Mid-study (after MBSR class 4) the subject will be asked to complete mid-study questionnaires at home on Survey Monkey or on paper if they choose. At the end of the MBSR training in which the subject will have to complete at least 3 visits, functional (f)MRI procedure will be repeated and compared against the first. Three months after completing the study there will be a follow-up visit to complete behavioral/symptom/quality of life questionnaires on line via SurveyMonkey. This is to see if the changes in the biomarkers will mediate changes in these behavioral measures 3-mo post Treatment (i.e. measure stability).

All in all, to complete the study subjects will have a screening visit, pre and post training MRI visit, up to 9 MBSR training visits, mid study questionnaires, a 4-hr retreat visit after week 6 and a final 3-mo f/u visit for questionnaires only.

Conditions

Post Traumatic Headache

Keywords

MBSR; fMRI; PTH

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

MBSR Training

Mindfulness Based Stress Reduction (MBSR) Training

Group Type: OTHER

MBSR

Intervention Type: BEHAVIORAL

Behavioral

Interventions

MBSR

Behavioral

Intervention Type: BEHAVIORAL

Other Intervention Names

Mindfullness Based Stress Reduction Training

Eligibility Criteria

Inclusion Criteria

• Males and female veterans at least 18 years of age
• Mild post traumatic headaches, diagnosed by a physician
• No prior training in MBSR or other mindfulness or meditation training will be allowed
• Able to read and speak English
• No participation in a clinical trial within the last 28 days

Exclusion Criteria

• Current severe psychiatric diagnoses (e.g., schizophrenia, bipolar disorder, claustrophobia, history of panic attacks)
• Significant co-morbid condition(s) such as insulin-dependent diabetes, cancer, obesity (BMI>35), severe lung disease, neurological conditions (e.g., seizures), uncontrolled hypertension, or significant heart disease
• History of persistent headaches prior to TBI
• Unsafe for MRI (e.g., metal objects/shrapnel, metallic implants, brain or skull abnormalities, and claustrophobia)
• Use of centrally acting medications that will interfere with the neuroimaging testing (e.g. narcotic medications)
• Daily use of illicit drugs or marijuana
• Daily alcohol consumption of greater than 2 units

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

VA Medical Center-West Los Angeles

FED

Sponsor Role: collaborator

National Center for Complementary and Integrative Health (NCCIH)

NIH

Sponsor Role: collaborator

University of California, Los Angeles

OTHER

Sponsor Role: lead

Responsible Party

Kirsten Tillisch, MD

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kirsten Tillisch, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, Los Angeles

Locations

VA West Los Angeles Medical Center

Los Angeles, California, United States

Countries

United States

Other Identifiers

R01AT007137

Identifier Type: NIH

Identifier Source: secondary_id

View Link

13-000864

Identifier Type: -

Identifier Source: org_study_id