Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study

NCT ID: NCT02128139

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-04-30

Study Completion Date

2015-10-31

Brief Summary

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Introduction. Comprehensive data on infective endocarditis in developing countries are scarce.

Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis in low-income countries.

Methods : Prospective, Observational, Multicentre study. Inclusion criteria: patients aged over 1 year fulfilling the modified Duke criteria for infective endocarditis.

Exclusion criteria: patient included during a previous infective endocarditis episode.

Outcomes measures: Mortality at 6 months follow-up; mortality at 1 month follow-up; access to antibiotic treatment (modalities and duration), hospital length of stay and reason for discharge, and cardiac surgery when indicated.

Duration: One year (June 2014- June 2015)

Detailed Description

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Conditions

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Infective Endocarditis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients aged over 1 year diagnosed with infective endocarditis according to the modified Duke criteria

Exclusion Criteria

* Already included for a previous episode of infective endocarditis (i.e., relapse or reinfection)
Minimum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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War Memorial Hospital

OTHER

Sponsor Role collaborator

Centers for Disease Control and Prevention

FED

Sponsor Role collaborator

Oxford University Hospitals NHS Trust

OTHER

Sponsor Role collaborator

St. Elizabeth Catholic General Hospital Shisong, Cameroun

UNKNOWN

Sponsor Role collaborator

CHU de Brazzaville, Congo Brazzaville

UNKNOWN

Sponsor Role collaborator

Polyclinique International de Bamako, Mali

UNKNOWN

Sponsor Role collaborator

CHR de Saint-Louis Lt Colonel Mamadou Diouf, Sénégal

UNKNOWN

Sponsor Role collaborator

Hôpital Général de Grand Yoff de Dakar, Sénégal

UNKNOWN

Sponsor Role collaborator

Bafoussam Regional Hospital, Cameroon

UNKNOWN

Sponsor Role collaborator

Hospital Laquinitinie de Douala

UNKNOWN

Sponsor Role collaborator

Yaounde Central Hospital

OTHER_GOV

Sponsor Role collaborator

National Hospital of Niamey

OTHER

Sponsor Role collaborator

Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou, Benin

UNKNOWN

Sponsor Role collaborator

Hospital General De Douala

OTHER

Sponsor Role collaborator

Eduardo Mondlane University

OTHER

Sponsor Role collaborator

Laos Oxford Mahosot Wellcome Research Unit

UNKNOWN

Sponsor Role collaborator

Mulago Hospital, Uganda

OTHER

Sponsor Role collaborator

Fann Hospital, Senegal

UNKNOWN

Sponsor Role collaborator

Institute of Cardiology Abidjan

UNKNOWN

Sponsor Role collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Joseph Kado

Suva, , Fiji

Site Status

Paul N. Newton

Vientiane, , Laos

Site Status

Beatriz Ferreira

Maputo, , Mozambique

Site Status

Abdul Kane

Dakar, , Senegal

Site Status

Bara Diop

Dakar, , Senegal

Site Status

Emmy Okello

Kampala, , Uganda

Site Status

Countries

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Fiji Laos Mozambique Senegal Uganda

Other Identifiers

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Cardiology and Development

Identifier Type: OTHER

Identifier Source: secondary_id

C12-37 / EndoDev

Identifier Type: -

Identifier Source: org_study_id

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