The Effect of Whole Body Vibration on Spasticity in Persons With Spinal Cord Injury

NCT ID: NCT02127606

Last Updated: 2014-11-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Brief Summary

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Extended periods of tilt table standing have been observed to improve spasticity in individuals with spinal cord injury (SCI). The purpose of this study is to determine the effect of three sessions of whole body vibration while tilt table standing on spasticity in individuals with a complete or incomplete SCI above the neurological level of T10. Participants in this study will undergo whole body vibration while standing on a tilt table for a total of approximately 14 minutes for a total of 3 sessions on 3 separate days. Spasticity monitoring will be evaluated prior to and after the intervention with the Modified Penn Spasm Frequency Scale, an interview to obtain the individual's perception and impression of the effect of whole body vibration on the performance of activities of daily living, quality of life, pain scale, and global impression of change.

Detailed Description

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Conditions

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Spinal Cord Injury Spasticity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Vibration with tilt-table standing

Participants in this arm will undergo alternating side-to-side, whole body vibration while standing on a tilt table for multiple treatments for a total of approximately 14 minutes for 3 sessions over 3 different days

Group Type EXPERIMENTAL

Vibration with tilt-table standing

Intervention Type DEVICE

Interventions

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Vibration with tilt-table standing

Intervention Type DEVICE

Other Intervention Names

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Galileo Tilt-Table Galileo System Vibrating platform Whole-body vibration with tilt-table standing

Eligibility Criteria

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Inclusion Criteria

* The subject is male or female, 18 to 70 years of age, inclusive.
* The subject has neurological impairment secondary to a spinal cord injury that occurred at least six (6) months prior to the study that can be categorized as either a complete or incomplete spinal cord injury.
* The neurological level of lesion is above T10.
* The subject has self-reported stable moderate to severe spasticity (Modified Ashworth Score scale at or greater than a 2 at the hips or knees). Patients can be enrolled if on a stable dose of oral medications or intrathecal medications.
* The subject has self reported spasticity that negatively impacts his or her quality of life, impairs ability to perform activities of daily living (such as transfers, sitting, sleep, wheelchair use, and hobbies).
* The subject is able to stand with the assistance of a tilt table at a minimum of 70 degrees for 45 minutes without significant orthostasis or other adverse events or symptoms.
* The subject is able and willing to comply with the protocol.
* The subject is able to and has voluntarily given informed consent prior to the performance of any study-specific procedures.

Exclusion Criteria

* The subject does not self report lower limb spasticity.
* The subject does not have self reported spasticity that negatively impacts his or her quality of life, impairs ability to perform activities of daily living (such as transfers, sitting, sleep, wheelchair use, and hobbies).
* The subject experiences symptoms consistent with infection, including but not limited to fever, chills, dysuria, gallbladder or kidney stones.
* The subject experiences pain that is not well controlled with consistent pain medication use.
* The subject has recent thromboembolism, diabetes mellitus, intractable hypertension or cardiac/pulmonary instability, internal fixation implants, acute thrombosis, pregnancy, acute inflammation of the locomotor system including active arthrosis or arthropathy, acute tendinopathy, acute hernia, acute discopathy, recent post-surgical wounds, epilepsy, rheumatoid arthritis, or recent fractures\<6 months.
* The subject has a lumbar spinal hardware or artificial joints in the lower extremities.
* The subject is participating in any experimental studies that could alter the patient's spasticity.
* The subject has a concomitant brain injury or other cognitive deficits that would preclude following instructions.
* The subject has skin breakdown in areas receiving direct pressure during tilt table standing.
* The subject has any medical condition, including psychiatric disease that would interfere with the interpretation of the study results or the conduct of the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kessler Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Steven C. Kirshblum, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kessler Institute for Rehabilitation

Trevor A. Dyson-Hudson, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kessler Foundation

Locations

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Kessler Institute for Rehabilitation

West Orange, New Jersey, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Trevor A. Dyson-Hudson, M.D.

Role: CONTACT

Phone: 973-324-3576

Email: [email protected]

Steven C. Kirshblum, M.D.

Role: CONTACT

Phone: 800-248-3221

Email: [email protected]

Facility Contacts

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Trevor A. Dyson-Hudson, M.D.

Role: primary

Matthew Weiner

Role: backup

Other Identifiers

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R-811-14

Identifier Type: -

Identifier Source: org_study_id