Metabolic and Cardiovascular Impact of CD36 Deficiency in African Americans
NCT ID: NCT02126735
Last Updated: 2016-12-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
21 participants
OBSERVATIONAL
2013-08-31
2016-12-31
Brief Summary
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The purpose of this study is to compare the levels of fat in the blood and to assess endothelial dysfunction among carriers versus non-carriers of the coding SNP, rs3211938 of the CD36 gene after a high fat meal challenge
Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
* BMI 25-45 kg/m2
Exclusion Criteria
* Pregnancy
* Use of nicotinic acid for dyslipidemia
* History of nutrient malabsorption
* Clinically significant hepatic or renal disease, OR serum creatinine or liver function tests \> 2times upper limits of normal
* Symptomatic acute or chronic gallbladder disease
* Any underlying or acute disease requiring regular medication which could in the principal investigator's opinion possibly pose a threat to the subject or make implementation of the protocol difficult
* Mental conditions rendering the subject unable to understand the nature, scope and possible consequences of the study
* Patient unwilling or unable to give informed consent
18 Years
65 Years
ALL
Yes
Sponsors
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Vanderbilt University Medical Center
OTHER
Responsible Party
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Cyndya Shibao
Assistant Professor of Medicine
Principal Investigators
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Cyndya A Shibao, MD
Role: PRINCIPAL_INVESTIGATOR
Vanderbilt University
Locations
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Vanderbilt University
Nashville, Tennessee, United States
Countries
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References
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Shibao CA, Celedonio JE, Tamboli R, Sidani R, Love-Gregory L, Pietka T, Xiong Y, Wei Y, Abumrad NN, Abumrad NA, Flynn CR. CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. J Clin Endocrinol Metab. 2018 May 1;103(5):1856-1866. doi: 10.1210/jc.2017-01982.
Marinos A, Celedonio JE, Ramirez CE, Gottlieb J, Gamboa A, Hui N, Yu C, Stein CM, Biaggioni I, Shibao CA. Time-Course Analysis of Flow Mediated Dilation for the Evaluation of Endothelial Function After a High-Fat Meal in African Americans. J Am Heart Assoc. 2015 Nov 5;4(11):e002388. doi: 10.1161/JAHA.115.002388.
Other Identifiers
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121525
Identifier Type: -
Identifier Source: org_study_id