Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function
NCT ID: NCT02123641
Last Updated: 2017-09-25
Study Results
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Basic Information
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ACTIVE_NOT_RECRUITING
NA
451 participants
INTERVENTIONAL
2014-04-30
2028-06-30
Brief Summary
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Each individual will be randomized into one of three groups stratified according to gender (M/F), BMI (≤28/\>28), and 30 sec chair stand (≤11/\>11). The three groups are Heavy resistance training (n=150), moderate intensity training (n=150), and control (n=150, no training).
Assessments will be performed at baseline, after 12 months of intervention. Furthermore, follow up will be performed after 2,4,7, and 10 years.
The primary outcome is change in leg extensor power after the intervention and during follow up.
The primary hypothesis is that by applying the intention-to-treat analysis, the moderate intensity training group will increase leg extensor power just as much as the heavy resistance training group. The two training groups will increase muscle power more than the control group.
Detailed Description
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Interventions to promote physical activity in adults aged 55 to 70 years have been shown to be effective at 12 months but it is very unclear if the effect is maintained thereafter. Both exercise at home or at a center improves health and physical function - but home based programs appear to be superior to center based programs in terms of adherence to exercise especially in the long-term.
In older adults, strength training at 60% of 1RM has been shown to be sufficient for large effect on muscle function and muscle protein synthesis, and potentially lower loads (45-60% 1RM) have effect when adding more repetitions.
The overall objective of the study is to assess the long-term effects of 12 month of supervised high-intensity center based resistance training or "guided" moderate-intensity home-based resistance training relative to a non-exercising control group upon muscle power, -strength and -mass, physical function, physical activity level and health in older people around the time of retirement.
The hypotheses are:
1. Supervised high-intensity center based resistance training over one year results in the best improvement in muscle power and bodily function
2. "Guided" moderate-intensity home-based resistance training will result in a more active lifestyle and thus in sustained elevated activity level after the 1-year intervention period. Thus in the long run (several years) "guided" moderate-intensity home-based resistance training has superior effects compared to supervised high-intensity center based resistance training upon functional ability, health and potentially also cognitive function.
450 participants recruited through advertisements in local newspapers will be included in this three-armed, single-blinded randomized trial. After baseline assessment they will be randomized to one year of 1) supervised, high-intensity progressive, resistance training conducted in machines three times weekly in a local fitness center 2) "guided" moderate-intensity home-based resistance training conducted with elastic bands and body weight three times weekly. "Guided" means that the participants are offered supervised resistance training once weekly in addition to home based resistance training 2 times weekly or 3) various social and cultural activities that do not require physical activity.
All participants complete a wide range of tests before and after the 12 months intervention period and the primary time point for outcome assessment will be at 12 month. The same "test battery" is conducted in the subsequent years (2, 4, 7, and 10 years later) as a follow-up.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Heavy resistance training
Heavy resistance training of the lower and upper extremities three times weekly for 52 weeks.
Heavy resistance training
Supervised heavy resistance training three times weekly for 52 weeks.
Moderate intensity training
Home-based moderate intensity training of the lower and upper extremities three times weekly for 52 weeks.
Moderate intensity training
Moderate intensity training supervised once weekly and home based unsupervised two times weekly for 52 weeks.
Control
No training
Control
No training
Interventions
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Heavy resistance training
Supervised heavy resistance training three times weekly for 52 weeks.
Moderate intensity training
Moderate intensity training supervised once weekly and home based unsupervised two times weekly for 52 weeks.
Control
No training
Eligibility Criteria
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Inclusion Criteria
* Between 62 and 70 years
Exclusion Criteria
* Severe chronic obstructive pulmonary disease, cardiac arrhythmias or known decreased left ventricular ejection fraction, non-treated hyper/hypothyroidism, dementia, active cancer.
* Surgical diseases: Bone, muscle, tendon or joint injuries compromising participation in exercise regimens.
* Implanted magnetic devices incompatible with MRi-scanning.
* \>1 hour of exercise weekly, except light activities such as stretching/gymnastics and bike-riding/walking as transportation.
62 Years
70 Years
ALL
Yes
Sponsors
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University of Copenhagen
OTHER
Hvidovre University Hospital
OTHER
Bispebjerg Hospital
OTHER
Responsible Party
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Michael Kjaer
Professor
Principal Investigators
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Kasper Dideriksen, PhD stud
Role: PRINCIPAL_INVESTIGATOR
Bispebjerg Hospital
Anne Gylling, PhD stud
Role: PRINCIPAL_INVESTIGATOR
Bispebjerg Hospital
Christian Eriksen, PhD stud
Role: PRINCIPAL_INVESTIGATOR
Bispebjerg Hospital
Michael Kjaer, MD, Proff
Role: PRINCIPAL_INVESTIGATOR
Bispebjerg Hospital
Andreas Ziegler, PhD stud
Role: PRINCIPAL_INVESTIGATOR
Bispebjerg Hospital
Locations
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Bispebjerg Hospital
Copenhagen NV, , Denmark
Countries
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References
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Bloch-Ibenfeldt M, Demnitz N, Gates AT, Garde E, Siebner HR, Kjaer M, Boraxbekk CJ. No long-term benefits from resistance training on brain grey matter volumes in active older adults at retirement age. BMC Geriatr. 2025 Feb 21;25(1):120. doi: 10.1186/s12877-025-05778-z.
Bloch-Ibenfeldt M, Gates AT, Jorgensen NR, Linneberg A, Aadahl M, Kjaer M, Boraxbekk CJ. Heavy resistance training provides short-term benefits on bone formation in well-functioning older adults. Bone. 2025 Apr;193:117393. doi: 10.1016/j.bone.2025.117393. Epub 2025 Jan 18.
Bloch-Ibenfeldt M, Theil Gates A, Karlog K, Demnitz N, Kjaer M, Boraxbekk CJ. Heavy resistance training at retirement age induces 4-year lasting beneficial effects in muscle strength: a long-term follow-up of an RCT. BMJ Open Sport Exerc Med. 2024 Jun 18;10(2):e001899. doi: 10.1136/bmjsem-2024-001899. eCollection 2024.
Gylling AT, Eriksen CS, Garde E, Wimmelmann CL, Reislev NL, Bieler T, Ziegler AK, Andersen KW, Bauer C, Dideriksen K, Baekgaard M, Mertz KH, Bayer ML, Bloch-Ibenfeldt M, Boraxbekk CJ, Siebner HR, Mortensen EL, Kjaer M. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults. Exp Gerontol. 2020 Jul 15;136:110939. doi: 10.1016/j.exger.2020.110939. Epub 2020 Apr 8.
Modig K, Talback M, Ziegler L, Ahlbom A. Temporal trends in incidence, recurrence and prevalence of stroke in an era of ageing populations, a longitudinal study of the total Swedish population. BMC Geriatr. 2019 Feb 4;19(1):31. doi: 10.1186/s12877-019-1050-1.
Eriksen CS, Svensson RB, Gylling AT, Couppe C, Magnusson SP, Kjaer M. Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults. BMC Geriatr. 2019 Jan 31;19(1):30. doi: 10.1186/s12877-019-1043-0.
Eriksen CS, Garde E, Reislev NL, Wimmelmann CL, Bieler T, Ziegler AK, Gylling AT, Dideriksen KJ, Siebner HR, Mortensen EL, Kjaer M. Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study). BMJ Open. 2016 Dec 2;6(12):e012951. doi: 10.1136/bmjopen-2016-012951.
Other Identifiers
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H-3-2014-017
Identifier Type: -
Identifier Source: org_study_id