The Efficacy of Steroid Therapy in Vestibular Neuritis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-06-30

Brief Summary

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The purpose of this study was to compare the treatment effectiveness of steroid therapy for vestibular neuritis by using video head impulse test.

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Detailed Description

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This study was a prospective, randomized controlled study. The enrolled vestibular neuritis patients were randomized to conservative treatment or steroid treatment when they are diagnosed with caloric test. After initial vestibular work-up including caloric, video head impulse tests, and a questinnaire (DHI), the patient was examined with the same tests again at 6 months later. The efficacy of steroid for the patients with vestibular neuritis would be determined by the comparison of the data of each group.

Conditions

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Vestibular Neuritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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: Ginkgo biloba & methylprednisolone

Patients receive Ginkgo biloba \& methylprednisolone per oral.

Group Type ACTIVE_COMPARATOR

Ginkgo biloba & Methylprednisolone

Intervention Type DRUG

Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month. Methylprednisolone 48 mg/day(per oral, once a day for first 9 days. And then methylprednisolone tapering was started every 2 days. The entire duration of methylprednisolone treatment was 14 days.

Ginkgo biloba

Patients receive Ginkgo biloba per oral.

Group Type PLACEBO_COMPARATOR

Ginkgo biloba

Intervention Type DRUG

Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month.

Interventions

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Ginkgo biloba & Methylprednisolone

Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month. Methylprednisolone 48 mg/day(per oral, once a day for first 9 days. And then methylprednisolone tapering was started every 2 days. The entire duration of methylprednisolone treatment was 14 days.

Intervention Type DRUG

Ginkgo biloba

Ginkgo biloba 160 mg/day (per oral, 80 mg twice a day) for 1 month.

Intervention Type DRUG

Other Intervention Names

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Ginexin Methylprednisolone Ginexin

Eligibility Criteria

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Inclusion Criteria

* Ages over 18 years
* Acute vertigo that occurred within 7 days
* The spontaneous nystagmus should be detected
* Caloric weakness over 20%

Exclusion Criteria

* Suspicious or verified a central nervous system lesion
* If the patient has denied.
* Other otologic disease (acute/chronic otitis media, otosclerosis, etc)
* The patient with history of otologic surgery
* The patient with history of brain surgery

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No