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Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury

NCT ID: NCT02097784

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2018-07-31

Brief Summary

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This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome. This echocardiography will be done before the volemic expansion and the final diagnostic of hepatorenal syndrome or prerenal azotemia. The primary endpoint is to describe the hemodynamic characteristics of this population at the time of acute kidney injury and their association with diagnostic of hepatorenal syndrome or prerenal azotemia. Patients with elevated filling pressure, predicting poor outcome of volemic expansion will be excluded of the study after the echocardiography and will not undergo volemic expansion but appropriate management.

Detailed Description

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Conditions

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Cirrhosis Hepatorenal Syndrome Acute Kidney Injury Diastolic Function

Keywords

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cirrhosis hepatorenal syndrome acute kidney injury diastolic function

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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cirrhosis with portal hypertension,ascite and acute kidney

Group Type OTHER

Echocardiography

Intervention Type PROCEDURE

Interventions

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Echocardiography

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients \> 18 years
* written consent for the participation of the study
* cirrhosis with portal hypertension and ascite
* acute kidney injury according to AKIN criteria (rapid increase of creatinine (48 hours) \> 26.4 µmol or \> 50% comparing with baseline). Baseline creatinine is the last value of creatinine before admission or creatinine at the admission if stable during 5 days.
* absence of argument for acute tubular necrosis or other organic acute renal injury
* absence of argument for shock

Exclusion Criteria

* pregnant women
* volemic expansion before echocardiography
* portal thrombosis
* presence of TIPSS
* history of cardiac or renal pathology
* atrial fibrillation
* cardiac valvulopathy
* technical limitation due to echogenicity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Fanny LEBOSSE, Dr

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon

Locations

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Hospices Civils de Lyon - Hôpital de la Croix-Rousse

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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2013-A01622-43

Identifier Type: OTHER

Identifier Source: secondary_id

2013.831

Identifier Type: -

Identifier Source: org_study_id