Trial Outcomes & Findings for Daily Disposable Comparison Study (NCT NCT02094677)

NCT ID: NCT02094677

Last Updated: 2020-07-28

Results Overview

Participant's subjective response for lens preference of filcon II 3 and etafilcon A after 3 hours lens wear rated by questionnaire. (5 possible ratings: Strongly prefer filcon II 3, Slightly prefer filcon II 3, No preference, Slightly prefer etafilcon A/nelfilcon A, Strongly prefer etafilcon A/nelfilcon A).

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

70 participants

Primary outcome timeframe

3 hours

Results posted on

2020-07-28

Participant Flow

Seventy four participants were enrolled into the study and 70 participants were randomized and completed the study. 40 were habitual wearers of etafilcon A lens and 30 were habitual wearers of nelfilcon A lens.

Participant milestones

Participant milestones
Measure
Filcon II 3 and Etafilcon A
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Overall Study
STARTED
43
31
Overall Study
COMPLETED
40
30
Overall Study
NOT COMPLETED
3
1

Reasons for withdrawal

Reasons for withdrawal
Measure
Filcon II 3 and Etafilcon A
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Overall Study
Screening
3
1

Baseline Characteristics

Daily Disposable Comparison Study

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Total
n=70 Participants
Total of all reporting groups
Age, Continuous
28 years
STANDARD_DEVIATION 9 • n=5 Participants
33.1 years
STANDARD_DEVIATION 12.4 • n=7 Participants
30.2 years
STANDARD_DEVIATION 10.8 • n=5 Participants
Sex: Female, Male
Female
27 Participants
n=5 Participants
23 Participants
n=7 Participants
50 Participants
n=5 Participants
Sex: Female, Male
Male
13 Participants
n=5 Participants
7 Participants
n=7 Participants
20 Participants
n=5 Participants
Region of Enrollment
Canada
40 participants
n=5 Participants
30 participants
n=7 Participants
70 participants
n=5 Participants

PRIMARY outcome

Timeframe: Baseline visit

Participant's subjective response for lens preference of filcon II 3 and etafilcon A or filcon II 3 and nelfilcon A at baseline visit, following insertion, after settling 10-15mins (surveyed at baseline visit) rated by questionnaire. (5 possible ratings: Strongly prefer filcon II 3, Slightly prefer filcon II 3, No preference, Slightly prefer etafilcon A/nelfilcon A, Strongly prefer etafilcon A/nelfilcon A).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Strongly prefer filcon II 3
1 participants
3 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Slightly prefer filcon II 3
14 participants
8 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
No preference
8 participants
10 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Slightly prefer etafilcon A/nelfilcon A
8 participants
6 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Strongly prefer etafilcon A/nelfilcon A
9 participants
3 participants

PRIMARY outcome

Timeframe: 3 hours

Participant's subjective response for lens preference of filcon II 3 and etafilcon A after 3 hours lens wear rated by questionnaire. (5 possible ratings: Strongly prefer filcon II 3, Slightly prefer filcon II 3, No preference, Slightly prefer etafilcon A/nelfilcon A, Strongly prefer etafilcon A/nelfilcon A).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Strongly prefer filcon II 3
1 participants
3 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Slightly prefer filcon II 3
10 participants
12 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
No preference
7 participants
5 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Slightly prefer etafilcon A/nelfilcon A
13 participants
8 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Strongly prefer etafilcon A/nelfilcon A
9 participants
2 participants

PRIMARY outcome

Timeframe: 6 hours

Participant's subjective response for lens preference of filcon II 3 and etafilcon A after 6 hours lens wear rated by questionnaire (5 possible ratings: Strongly prefer filcon II 3, Slightly prefer filcon II 3, No preference, Slightly prefer etafilcon A/nelfilcon A, Strongly prefer etafilcon A/nelfilcon A).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Strongly prefer filcon II 3
2 participants
5 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Slightly prefer filcon II 3
9 participants
8 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
No preference
7 participants
9 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Slightly prefer etafilcon A/nelfilcon A
11 participants
5 participants
Lens Preference - Filcon II 3 and Etafilcon A or Filcon II 3 and Nelfilcon A
Strongly prefer etafilcon A/nelfilcon A
11 participants
3 participants

SECONDARY outcome

Timeframe: Baseline, 3 hours, 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens comfort of filcon II 3 and etafilcon A after settling 10-15mins (surveyed at baseline visit, 3 hours, and 6 hours) rated by questionnaire (Scale 0-100, 0=cannot be worn, causes pain, 100=cannot be felt ever).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Comfort - Filcon II 3 and Etafilcon A
Habitual lens (before study lens dispensed)
78 units on a scale
Standard Deviation 18
77 units on a scale
Standard Deviation 20
Lens Comfort - Filcon II 3 and Etafilcon A
Baseline (study lens)
84 units on a scale
Standard Deviation 18
90 units on a scale
Standard Deviation 10
Lens Comfort - Filcon II 3 and Etafilcon A
3 hours
79 units on a scale
Standard Deviation 22
87 units on a scale
Standard Deviation 14
Lens Comfort - Filcon II 3 and Etafilcon A
6 hours
75 units on a scale
Standard Deviation 24
83 units on a scale
Standard Deviation 18

SECONDARY outcome

Timeframe: Baseline, 3 hours, 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens comfort of filcon II 3 and nelfilcon A after settling 10-15mins (surveyed at baseline visit, 3 hours, and 6 hours) rated by questionnaire (Scale 0-100, 0=cannot be worn, causes pain, 100=cannot be felt ever).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Comfort - Filcon II 3 and Nelficon A
Habitual lens (before study lens dispensed)
67 units on a scale
Standard Deviation 17
67 units on a scale
Standard Deviation 18
Lens Comfort - Filcon II 3 and Nelficon A
Baseline (study lens)
85 units on a scale
Standard Deviation 14
88 units on a scale
Standard Deviation 14
Lens Comfort - Filcon II 3 and Nelficon A
3 hours
79 units on a scale
Standard Deviation 16
75 units on a scale
Standard Deviation 17
Lens Comfort - Filcon II 3 and Nelficon A
6 hours
76 units on a scale
Standard Deviation 24
72 units on a scale
Standard Deviation 23

SECONDARY outcome

Timeframe: 3 hours and 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens dryness of filcon II 3 and etafilcon A (surveyed at 3 and 6 hours after baseline visit) rated by questionnaire (Scale 0-100, 0=cannot be worn, extremely dry 100=no dryness experienced).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Dryness - Filcon II 3 and Etafilcon A
Habitual lens (before study lens dispensed)
72 units on a scale
Standard Deviation 19
70 units on a scale
Standard Deviation 20
Lens Dryness - Filcon II 3 and Etafilcon A
3 hours
78 units on a scale
Standard Deviation 24
85 units on a scale
Standard Deviation 15
Lens Dryness - Filcon II 3 and Etafilcon A
6 hours
75 units on a scale
Standard Deviation 23
82 units on a scale
Standard Deviation 18

SECONDARY outcome

Timeframe: 3 hours and 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens dryness of filcon II 3 and nelfilcon A (surveyed at 3 and 6 hours after baseline visit) rated by questionnaire (Scale 0-100, 0=cannot be worn, extremely dry, 100=no dryness experienced).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Dryness - Filcon II 3 and Nelfilcon A
Habitual lens (before study lens dispensedl
66 units on a scale
Standard Deviation 20
66 units on a scale
Standard Deviation 19
Lens Dryness - Filcon II 3 and Nelfilcon A
3 hours
79 units on a scale
Standard Deviation 16
76 units on a scale
Standard Deviation 19
Lens Dryness - Filcon II 3 and Nelfilcon A
6 hours
77 units on a scale
Standard Deviation 21
74 units on a scale
Standard Deviation 23

SECONDARY outcome

Timeframe: Baseline visit

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens handling of filcon II 3 and etafilcon A following insertion (surveyed at baseline visit) rated by questionnaire (Scale 0-100, 0=very hard to handle causes pain, 100=very easy to handle).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Handling - Filcon II 3 and Etafilcon A
Habitual lens (before study lens dispensed)
92 units on a scale
Standard Deviation 10
92 units on a scale
Standard Deviation 10
Lens Handling - Filcon II 3 and Etafilcon A
Baseline (study lens)
93 units on a scale
Standard Deviation 9
91 units on a scale
Standard Deviation 10

SECONDARY outcome

Timeframe: Baseline visit

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens handling of filcon II 3 and nelfilcon A following insertion (surveyed at baseline visit) rated by questionnaire (Scale 0-100, 0=very hard to handle, causes pain, 100=very easy to handle).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Handling - Filcon II 3 and Nelfilcon A
Habitual lens (before study lens dispensed)
90 units on a scale
Standard Deviation 14
90 units on a scale
Standard Deviation 14
Lens Handling - Filcon II 3 and Nelfilcon A
Baseline (study lens)
92 units on a scale
Standard Deviation 14
92 units on a scale
Standard Deviation 14

SECONDARY outcome

Timeframe: 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens handling of filcon II 3 and etafilcon A following insertion (surveyed 6 hours after baseline visit) rated by questionnaire (Scale 0-100, 0=very hard to handle, causes pain, 100=very easy to handle).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Handling (Removal) - Filcon II 3 and Etafilcon A
Habitual lens (before study lens dispensed)
95 units on a scale
Standard Deviation 10
95 units on a scale
Standard Deviation 10
Lens Handling (Removal) - Filcon II 3 and Etafilcon A
6 hours
95 units on a scale
Standard Deviation 12
97 units on a scale
Standard Deviation 6

SECONDARY outcome

Timeframe: 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants. Habitual data collected before study lens dispensed.

Participant's subjective response for lens handling of filcon II 3 and nelfilcon A following removal (surveyed 6 hours after baseline visit) rated by questionnaire (Scale 0-100, 0=very hard to handle, causes pain, 100=very easy to handle).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Handling (Removal) - Filcon II 3 and Nelfilcon A
Habitual lens (before study lens dispensed)
90 units on a scale
Standard Deviation 14
89 units on a scale
Standard Deviation 15
Lens Handling (Removal) - Filcon II 3 and Nelfilcon A
6 hours
94 units on a scale
Standard Deviation 16
94 units on a scale
Standard Deviation 10

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment for lens wettability of filcon II 3 and etafilcon A following insertion (assessed at baseline visit and 6 hours) by biomicroscopy (Scale 0-4, 0.25 increments, 0=excellent wettability, 4=severely reduced wettability).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Wettability - Filcon II 3 and Etafilcon A
Baseline
0.40 units on a scale
Standard Deviation 0.73
0.33 units on a scale
Standard Deviation 0.57
Lens Wettability - Filcon II 3 and Etafilcon A
6 hours
0.95 units on a scale
Standard Deviation 0.89
1.03 units on a scale
Standard Deviation 1.12

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment for lens wettability of filcon II 3 and nelficon A following insertion (assessed at baseline visit and 6 hours) by biomicroscopy (Scale 0-4, 0.25 increments, 0=excellent wettability, 4=severely reduced wettability).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Wettability - Filcon II 3 and Nelfilcon A
Baseline
0.38 units on a scale
Standard Deviation 0.46
0.25 units on a scale
Standard Deviation 0.35
Lens Wettability - Filcon II 3 and Nelfilcon A
6 hours
0.93 units on a scale
Standard Deviation 0.82
0.73 units on a scale
Standard Deviation 0.79

SECONDARY outcome

Timeframe: Baseline

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment for lens fit for centration of filcon II 3 and etafilcon A following insertion (assessed at baseline visit) by biomicroscopy (Optimum or Decentered N T S I). N - Nasal, T - Temporal, S - Superior, I - Interior, N/S - Nasal/Superior, N/I - Nasal/Interior, T/S - Temporal/Superior T/I - Temporal/Interior

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Centration - Filcon II 3 and Etafilcon A
Optimum
13 participants
13 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
N
0 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
T
8 participants
9 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
S
2 participants
4 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
I
5 participants
3 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
N/S
0 participants
0 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
N/I
0 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
T/S
5 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
T/I
7 participants
8 participants

SECONDARY outcome

Timeframe: 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment for lens fit for centration of filcon II 3 and etafilcon A following insertion (assessed at 6 hours) by biomicroscopy (Optimum or Decentered N T S I) N - Nasal, T - Temporal, S - Superior, I - Interior, N/S - Nasal/Superior, N/I - Nasal/Interior, T/S - Temporal/Superior, T/I - Temporal/Interior

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Centration - Filcon II 3 and Etafilcon A
Optimum
16 participants
14 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
N
0 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
T
9 participants
9 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
S
2 participants
5 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
I
2 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
N/S
1 participants
0 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
N/I
0 participants
0 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
T/S
6 participants
4 participants
Lens Fit, Centration - Filcon II 3 and Etafilcon A
T/I
4 participants
6 participants

SECONDARY outcome

Timeframe: Baseline

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment for lens fit for centration of filcon II 3 and nelfilcon A following insertion (assessed at baseline) by biomicroscopy (Optimum or Decentered N T S I) N - Nasal, T - Temporal, S - Superior, I - Interior, N/S - Nasal/Superior, N/I - Nasal/Interior, T/S - Temporal/Superior, T/I - Temporal/Interior

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
Optimum
11 participants
14 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
N
1 participants
0 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
T
3 participants
2 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
S
2 participants
2 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
I
3 participants
2 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
N/S
1 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
N/I
0 participants
2 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
T/S
7 participants
4 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
T/I
2 participants
3 participants

SECONDARY outcome

Timeframe: After 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment for lens fit for centration of filcon II 3 and nelfilcon A following insertion (assessed at 6 hours) by biomicroscopy (Optimum or Decentered N T S I) N - Nasal, T - Temporal, S - Superior, I - Interior, N/S - Nasal/Superior, N/I - Nasal/Interior, T/S - Temporal/Superior, T/I - Temporal/Interior

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
Optimum
11 participants
12 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
Nasal
1 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
T
4 participants
4 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
S
4 participants
2 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
I
0 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
N/S
1 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
N/I
0 participants
1 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
T/S
7 participants
4 participants
Lens Fit, Centration - Filcon II 3 and Nelfilcon A
T/I
2 participants
4 participants

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment for lens fit for Post-Blink Movement of filcon II 3 and etafilcon A following insertion (assessed at baseline visit and 6 hours) by biomicroscopy (measured in Primary Gaze and recorded in 0.1mm steps).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Post-Blink Movement - Filcon II 3 and Etafilcon A
Baseline
0.28 mm steps
Standard Deviation 0.15
0.24 mm steps
Standard Deviation 0.15
Lens Fit, Post-Blink Movement - Filcon II 3 and Etafilcon A
6 hours
0.30 mm steps
Standard Deviation 0.16
0.26 mm steps
Standard Deviation 0.14

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment for lens fit for Post-Blink Movement of filcon II 3 and nelfilcon A following insertion (assessed at baseline visit and 6 hours) by biomicroscopy (measured in Primary Gaze and recorded in 0.1mm steps).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Post-Blink Movement - Filcon II 3 and Nelfilcon A
Baseline
0.26 mm steps
Standard Deviation 0.11
0.24 mm steps
Standard Deviation 0.10
Lens Fit, Post-Blink Movement - Filcon II 3 and Nelfilcon A
6 hours
0.23 mm steps
Standard Deviation 0.08
0.24 mm steps
Standard Deviation 0.11

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment for lens fit for tightness of filcon II 3 and etafilcon A following insertion (assessed at baseline visit and 6 hours) by biomicroscopy (Percentage of tightness, 5 increments, 0-100, 0=extremely loose, 100=extremely tight).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Tightness - Filcon II 3 and Etafilcon A
Baseline
48 percentage of tightness
Standard Deviation 6
50 percentage of tightness
Standard Deviation 6
Lens Fit, Tightness - Filcon II 3 and Etafilcon A
6 hours
49 percentage of tightness
Standard Deviation 5
51 percentage of tightness
Standard Deviation 6

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment for lens fit for tightness of filcon II 3 and nelfilcon A following insertion (assessed at baseline visit and 6 hours) by biomicroscopy (Percentage of tightness, 5 increments, 0-100, 0=extremely loose, 100=extremely tight).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Fit, Tightness - Filcon II 3 and Nelfilcon A
Baseline
50 percentage of tightness
Standard Deviation 7
52 percentage of tightness
Standard Deviation 7
Lens Fit, Tightness - Filcon II 3 and Nelfilcon A
6 hours
52 percentage of tightness
Standard Deviation 6
53 percentage of tightness
Standard Deviation 8

SECONDARY outcome

Timeframe: 6 hour

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment for lens surface deposition of filcon II 3 and etafilcon A following insertion (assessed at 6 hour visit) by biomicroscopy (Scale 0-4, 0.25 steps, 0=no deposits, 4=severe deposits).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Surface Deposition - Filcon II 3 and Etafilcon A
0.26 units on a scale
Standard Deviation 0.27
0.37 units on a scale
Standard Deviation 0.47

SECONDARY outcome

Timeframe: 6 hour

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment for lens surface deposition of filcon II 3 and nelfilcon A following insertion (assessed at 6 hour visit) by biomicroscopy (Scale 0-4, 0.25 steps, 0=no deposits, 4=severe deposits).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Lens Surface Deposition - Filcon II 3 and Nelfilcon A
0.27 units on a scale
Standard Deviation 0.33
0.30 units on a scale
Standard Deviation 0.32

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment of High Contrast Visual Acuity following filcon II 3 and etafilcon A insertion (assessed at baseline visit and 6 hours) by computerized charts. (Positive logMAR values indicate poorer vision, negative values denote better vision than baseline 20/20 value).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
High Contrast Visual Acuity - Filcon II 3 and Etafilcon A
Baseline
-0.08 logMAR
Standard Deviation 0.07
-0.06 logMAR
Standard Deviation 0.07
High Contrast Visual Acuity - Filcon II 3 and Etafilcon A
6 hours
-0.09 logMAR
Standard Deviation 0.07
-0.07 logMAR
Standard Deviation 0.08

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment of High Contrast Visual Acuity following filcon II 3 and nelfilcon A insertion (assessed at baseline visit and 6 hours) by computerized charts. (Positive logMAR values indicate poorer vision, negative values denote better vision than baseline 20/20 value)

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
High Contrast Visual Acuity - Filcon II 3 and Nelfilcon A
Baseline
-0.07 logMAR
Standard Deviation 0.07
-0.07 logMAR
Standard Deviation 0.07
High Contrast Visual Acuity - Filcon II 3 and Nelfilcon A
6 hours
-0.08 logMAR
Standard Deviation 0.07
-0.10 logMAR
Standard Deviation 0.08

SECONDARY outcome

Timeframe: 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment of corneal staining (extent) assessed at screening (before lens insertion) by biomicroscopy (Grade as a % of each zone). N - Nasal, T - Temporal, S - Superior, I - Interior, C - Central

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Etafilcon A
N
4 percentage of the area of each zone
Standard Deviation 8
0 percentage of the area of each zone
Standard Deviation 1
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Etafilcon A
T
1 percentage of the area of each zone
Standard Deviation 6
1 percentage of the area of each zone
Standard Deviation 2
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Etafilcon A
S
3 percentage of the area of each zone
Standard Deviation 8
2 percentage of the area of each zone
Standard Deviation 5
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Etafilcon A
I
9 percentage of the area of each zone
Standard Deviation 12
4 percentage of the area of each zone
Standard Deviation 6
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Etafilcon A
C
0 percentage of the area of each zone
Standard Deviation 2
0 percentage of the area of each zone
Standard Deviation 1

SECONDARY outcome

Timeframe: 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment of corneal staining (extent) assessed at 6 hours by biomicroscopy (Grade as a % of each zone). N - Nasal, T - Temporal, S - Superior, I - Interior, C - Central

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Nelfilcon A
N
2 percentage of the area of each zone
Standard Deviation 5
2 percentage of the area of each zone
Standard Deviation 5
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Nelfilcon A
T
1 percentage of the area of each zone
Standard Deviation 5
0 percentage of the area of each zone
Standard Deviation 1
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Nelfilcon A
S
2 percentage of the area of each zone
Standard Deviation 5
2 percentage of the area of each zone
Standard Deviation 7
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Nelfilcon A
I
6 percentage of the area of each zone
Standard Deviation 8
4 percentage of the area of each zone
Standard Deviation 5
Ocular Health, Corneal Staining (Extent) - Filcon II 3 and Nelfilcon A
C
2 percentage of the area of each zone
Standard Deviation 9
0 percentage of the area of each zone
Standard Deviation 1

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and etafilcon A group which comprises of 40 participants.

The ophthalmologist's objective assessment of conjunctival bulbar and limbal hyperemia assessed at screening (before lens insertion) by biomicroscopy (Scale 0-4, 0.5 increments, 0=no redness, 4=redness).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=40 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Ocular Health, Conjunctival Hyperemia - Filcon II 3 and Etafilcon A
Bulbar
1.89 units on a scale
Standard Deviation 0.38
1.81 units on a scale
Standard Deviation 0.39
Ocular Health, Conjunctival Hyperemia - Filcon II 3 and Etafilcon A
Limbal
1.75 units on a scale
Standard Deviation 0.47
1.68 units on a scale
Standard Deviation 0.51

SECONDARY outcome

Timeframe: Baseline and 6 hours

Population: These results are between the filcon II 3 and nelfilcon A group which comprises of 30 participants.

The ophthalmologist's objective assessment of conjunctival bulbar and limbal hyperemia assessed at screening (before lens insertion of filcon II 3 and nelfilcon A) by biomicroscopy (Scale 0-4, 0.5 increments, 0=no redness, 4=redness).

Outcome measures

Outcome measures
Measure
Filcon II 3 and Etafilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. etafilcon A: Participants were randomized to wear etafilcon A control lens.
Filcon II 3 and Nelfilcon A
n=30 Participants
Participants were randomized to a test and control lens in a contralateral design. filcon II 3: Participants were randomized to wear filcon II 3 test lens. nelfilcon A: Participants were randomized to wear nelfilcon A control lens.
Ocular Health, Conjunctival Hyperemia - Filcon II 3 and Nelfilcon A
Bulbar
1.67 units on a scale
Standard Deviation 0.46
1.57 units on a scale
Standard Deviation 0.29
Ocular Health, Conjunctival Hyperemia - Filcon II 3 and Nelfilcon A
Limbal
1.35 units on a scale
Standard Deviation 0.49
1.27 units on a scale
Standard Deviation 0.37

Adverse Events

Filcon II 3 and Etafilcon A

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Filcon II 3 and Nelfilcon A

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Jose A. Vega, OD, Sr. Manager Global Medical Scientific Affairs

Coopervision

Phone: (925) 621-3761

Results disclosure agreements

  • Principal investigator is a sponsor employee Principal Investigators are NOT employed by the organization sponsoring the study. There IS an agreement between the Principal Investigator and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed. The investigators will not be permitted to publish or present at scientific meetings results obtained from the clinical study without prior written consent from the sponsor.
  • Publication restrictions are in place

Restriction type: OTHER