Study to Assess the Efficacy and Safety of SKI3246 in Subjects With Non-Constipation Irritable Bowel Syndrome

NCT ID: NCT02079675

Last Updated: 2015-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

279 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2014-04-30

Brief Summary

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The purpose of this study is to determine the efficacy and safety of different doses of SKI3246 compared with placebo in the treatment of patients with irritable bowel syndrome with non-constipation.

Detailed Description

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Conditions

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Non-constipation Irritable Bowel Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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SKI3246 Low Dose

Intervention: Drug: SKI3246 Low Dose

Group Type EXPERIMENTAL

SKI3246 Low Dose

Intervention Type DRUG

SKI3246 Low Dose will be taken for a 4-week duration (28 days) as 4 capsules a day: two capsules in the morning and two capsule in the evening

SKI3246 High Dose

Intervention: Drug: SKI3246 High Dose

Group Type EXPERIMENTAL

SKI3246 High Dose

Intervention Type DRUG

SKI3246 High Dose will be taken for a 4-week duration (28 days) as 4 capsules a day: two capsules in the morning and two capsule in the evening

Placebo

Intervention: Drug: Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

SKI3246 Placebo will be taken for a 4-week duration (28 days) as 4 capsules a day: two capsules in the morning and two capsule in the evening

Interventions

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SKI3246 Low Dose

SKI3246 Low Dose will be taken for a 4-week duration (28 days) as 4 capsules a day: two capsules in the morning and two capsule in the evening

Intervention Type DRUG

SKI3246 High Dose

SKI3246 High Dose will be taken for a 4-week duration (28 days) as 4 capsules a day: two capsules in the morning and two capsule in the evening

Intervention Type DRUG

Placebo

SKI3246 Placebo will be taken for a 4-week duration (28 days) as 4 capsules a day: two capsules in the morning and two capsule in the evening

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Have been diagnosed as non-constipation by ROME III.
* Patients who voluntarily signed written informed consent may participate in the study.

Exclusion Criteria

* Pregnant or lactating female.
* Patients with a history of inflammatory bowel disease.
* Severe neurological or psychological disease
* History of allergic reaction to the medications used in this study
* Use of other investigational drugs within 30 days prior to the study.
* Patients that investigators consider ineligible for this study
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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SK Chemicals Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hyo Jin Park, M.D.

Role: STUDY_CHAIR

Gangnam Severance Hospital, Yonsei University College of Medicine

Locations

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SK Chemicals

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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SKI3246_IBS_II_2012

Identifier Type: -

Identifier Source: org_study_id

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