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Metabolic Syndrome Cohort in Korea

NCT ID: NCT02077530

Last Updated: 2020-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2013-11-30

Study Completion Date

2023-11-30

Brief Summary

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Patients with metabolic syndrome living in Seoul area are included in this prospective registry for more than 10 years. All enrolled patients undergo thorough medical history survey. Enrolled patients will have coronary CT, 2D echocardiogram, treadmill test, pulse wave velocity, augmentation index, carotid intima-media thickness, and abdominal fat mass evaluation. Moreover, lipid profiles and inflammatory markers such as hsCRP, IL-6, TNF-alpha, VCAM-1, ICAM-1, adiponectin, MMP-9 will be measured. All participants will repeat the test and survey every year in Korea University Hospital.

Detailed Description

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Conditions

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Metabolic Syndrome

Keywords

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Patients with metabolic syndrome age between 30 to 64: Central obesity (Men ≥ 90 cm Women ≥ 85 cm), Plasma triglycerides ≥ 150 mg/dL HDL cholesterol Men < 40 mg/dL, Women < 50 mg/dL, Blood pressure ≥130/85 mm Hg (or treatment for hypertension), Fasting plasma glucose ≥ 100 mg/dL

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Central obesity: Men ≥ 90 cm Women ≥ 85 cm
* Plasma triglycerides ≥ 150 mg/dL
* HDL cholesterol Men \< 40 mg/dL, Women \< 50 mg/dL
* Blood pressure ≥130/85 mm Hg (or treatment for hypertension)
* Fasting plasma glucose ≥ 100 mg/dL
* Age between 30 to 64
* Consent to our registry protocol

Exclusion Criteria

* Patients who could not undergo coronary CT, 2D echocardiogram, treadmill test, and pulse wave velocity.
Minimum Eligible Age

30 Years

Maximum Eligible Age

64 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Korea University Anam Hospital

OTHER

Sponsor Role lead

Responsible Party

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Soon Jun Hong

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Korea University Anam Hospital Metabolic Syndrome Research Center

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Cho DH, Kim MN, Joo HJ, Shim WJ, Lim DS, Park SM. Visceral obesity, but not central obesity, is associated with cardiac remodeling in subjects with suspected metabolic syndrome. Nutr Metab Cardiovasc Dis. 2019 Apr;29(4):360-366. doi: 10.1016/j.numecd.2019.01.007. Epub 2019 Jan 29.

Reference Type DERIVED
PMID: 30782509 (View on PubMed)

Lee D, Joo HJ, Jung HW, Lim DS. Investigating potential mediator between statin and coronary artery calcification. PLoS One. 2018 Sep 18;13(9):e0203702. doi: 10.1371/journal.pone.0203702. eCollection 2018.

Reference Type DERIVED
PMID: 30226851 (View on PubMed)

Cho DH, Joo HJ, Kim MN, Lim DS, Shim WJ, Park SM. Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome. Cardiovasc Diabetol. 2018 Jun 30;17(1):95. doi: 10.1186/s12933-018-0735-7.

Reference Type DERIVED
PMID: 29960588 (View on PubMed)

Joo HJ, Cho SA, Cho JY, Lee S, Park JH, Yu CW, Hong SJ, Lim DS. Different Relationship Between Physical Activity, Arterial Stiffness, and Metabolic Status in Obese Subjects. J Phys Act Health. 2017 Sep;14(9):716-725. doi: 10.1123/jpah.2016-0595. Epub 2017 May 17.

Reference Type DERIVED
PMID: 28513244 (View on PubMed)

Other Identifiers

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MS in KUMC

Identifier Type: -

Identifier Source: org_study_id