Determination of Lung Maturity and Prediction of RDS at Birth

NCT ID: NCT02076126

Last Updated: 2015-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

145 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-01-31

Brief Summary

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The overall objective is to identify quickly after birth the preterm infants who will develop respiratory distress syndrome (RDS) for the purpose of treating them as early as possible with surfactant, to reduce, and if possible, to avoid sequelae, including long-term oxygen treatment.

We have therefore developed a quick test, which we believe will be ideal for this type of diagnostics, and will now test the method in a preclinical trial.

Detailed Description

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In at least 135 preterm infants with gestational age 24-32 weeks we will collect gastric aspirate and hypopharyngeal secretion. The infants are stratified into three groups: gestational age 24-25 weeks, 26-29 weeks and 30-31 weeks.

The aspirates will be frozen at -20 centigrade and lecithin-sphingomyelin ratio (L/S) will be analysed retrospectively using Fourier Transform Infrared Spectroscopy.

The infants will be monitored for the first five days with regard to possible development of RDS.

Clinical and biochemical data will be compared retrospectively.

There a no intervention procedures.

Conditions

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RDS Premature Birth

Keywords

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Lung maturity RDS Prematurity Lecithin-sphingomyelin ratio Spectroscopy Chemometrics

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Gastric aspirate

L/S ratio on the gastric aspirates are retrospectively compared with the possible development of RDS

No interventions assigned to this group

Hypopharyngeal secretion

L/S ratio on the hypopharyngeal secretions are retrospectively compared with the possible development of RDS

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Preterm infants with gestational ages of 24 (24+0) to 32 (31+6) weeks.
* Age \< ½ hour

Exclusion Criteria

* Lack of informed consent
* lack of aspirate
Minimum Eligible Age

1 Minute

Maximum Eligible Age

30 Minutes

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Holbaek Sygehus

OTHER

Sponsor Role collaborator

Aalborg University Hospital

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role collaborator

Aarhus University Hospital Skejby

OTHER

Sponsor Role collaborator

Kolding Sygehus

OTHER

Sponsor Role collaborator

Copenhagen University Hospital at Herlev

OTHER

Sponsor Role collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role collaborator

Hvidovre University Hospital

OTHER

Sponsor Role collaborator

Naestved Hospital

OTHER

Sponsor Role collaborator

University Hospital, Linkoeping

OTHER

Sponsor Role collaborator

Skane University Hospital

OTHER

Sponsor Role collaborator

Henrik Axel Verder

OTHER

Sponsor Role lead

Responsible Party

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Henrik Axel Verder

Professor DMSc

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Henrik Verder, Professor MD

Role: PRINCIPAL_INVESTIGATOR

Holbaek Hospital

Locations

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Holbaek Sygehus

Holbæk, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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Holb.SJ-384

Identifier Type: -

Identifier Source: org_study_id