Brain Changes by Rivastigmine According to Butyrylcholinesterase Alleles

NCT ID: NCT02063269

Last Updated: 2015-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2017-06-30

Brief Summary

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Butyrylcholinesterase (BuChE) activity is increasing in Alzheimer Disease (AD) process (Lane et al., 2006). BuChE wild type has stronger butyrylcholine esterase activity than BuChE K variant allele and this strong activity can affect AD brain negatively by choline depletion. Rivastigmine has unique dual action - acetylcholine esterase inhibition and butyrylcholine esterase inhibition. Therefore, rivastigmine can lower serum butyrylcholine esterase activity and delay functional decrease of Fluorodeoxyglucose positron emission tomography (FDG PET) images in AD patients with BuChE wild type allele by strong BuChE inhibition.

It suggests that rivastigmine can affect brain function differently by BuChE genotype in AD. Therefore, we will try to find the different changes of serum butyrylcholine esterase activity by ELISA and functional and structural changes of brain between BuChE wild type and K-variant type by FDG PET and MRI pre and post images after 12 month use of rivastigmine.

1. Primary objective:

1. the mean changes of Standardized Uptake Values (SUVmean) in PET imaging
2. the mean changes of serum BuChE activity between BuChE wild type and K-variant type.
2. Secondary objectives:

1. the mean changes of cortical thickness in brain MRI
2. the cognitive changes in Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog)
3. the cognitive changes in Mini-Mental State Exam (MMSE)
4. the daily function changes by Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL)
5. the behavioural changes by Caregiver-Administered Neuropsychiatric Inventory (NPI)
6. the disease severity changes by Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) between BuChE wild type and K-variant type.

Detailed Description

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Conditions

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Alzheimer's Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Rivastigmine

Rivastigmine

Group Type EXPERIMENTAL

Rivastigmine

Intervention Type DRUG

9-18mg/rivastigmine for 52 weeks

Interventions

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Rivastigmine

9-18mg/rivastigmine for 52 weeks

Intervention Type DRUG

Other Intervention Names

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Exelon

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Alzheimer's Disease (NINCD-ADRDA and MMSE between 10 \~26)
* Who didn't take Cholinesterase Inhibitor on liver within 3 months

Exclusion Criteria

* diagnosed with diseases other than AD that affect brain atrophy according to Brain MRI
* Diagnosed with diseases other than AD which affect cognitive functions (i.g. Schizophrenia, Major Depression, Mental Retardation, encephalopathy, etc.)
* Didn't suspect of drug or alcohol addictions within last decade
* Unable to participate the study due to poor sight and hearing
* Who aren't suitable to participate according to the researchers' judgement
Minimum Eligible Age

55 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Korea Ltd.

INDUSTRY

Sponsor Role collaborator

Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jun Young Lee

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul Metropolitan Government Seoul National University Boramae Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Reference Type BACKGROUND
PMID: 11086186 (View on PubMed)

Blesa R, Bullock R, He Y, Bergman H, Gambina G, Meyer J, Rapatz G, Nagel J, Lane R. Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease. Pharmacogenet Genomics. 2006 Nov;16(11):771-4. doi: 10.1097/01.fpc.0000220573.05714.ac.

Reference Type BACKGROUND
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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Reference Type BACKGROUND
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Other Identifiers

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CENA713DKR15T

Identifier Type: -

Identifier Source: org_study_id

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