PAZOFOS: Phase Ib and Phase II Trial of Pazopanib +/- Fosbretabulin in Advanced Recurrent Ovarian Cancer

NCT ID: NCT02055690

Last Updated: 2021-05-17

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 21 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-09-30
• Study Completion Date: 2017-11-24

Brief Summary

The first part of this study is to find the recommended dosages of a combination of two drugs: pazopanib and fosbretabulin, which will be given to female patients with relapsed ovarian cancer.

The second part of the study involves comparing the recommended dose of pazopanib and fosbretabulin in combination against pazopanib alone in female patients with relapsed ovarian cancer to determine whether the combination is more beneficial that pazopanib on it's own.

Detailed Description

Ovarian cancer is the fourth biggest contributor to female cancer mortality, accounting for 4% of all malignancies diagnosed in women. In the United Kingdom (UK), there are seven thousand new cases of ovarian cancer annually and four thousand two hundred deaths from the disease. The standard treatment approach currently consists of surgical debulking and chemotherapy, usually based around a combination of carboplatin and paclitaxel. Most ovarian cancers are initially chemo-responsive however the majority of patients whose disease initially responds subsequently develop recurrent disease.

Once patients recur, treatment options become less numerous and less effective. Progression free survival rates for platinum-sensitive disease are only about 13 months and the outlook for patients with platinum-resistant disease is much worse.

This study is exploring a new combination of drugs fosbretabulin, a vascular disrupting agent and pazopanib, a tyrosine kinase inhibitor. There is scientific rational for combining these two types of drugs as they should be able to work in combination through contrasting mechanisms of action.

The first part of the study is a dose finding exercise with cohorts of patients being given drugs with in combination until the recommended dose of both drugs is found. Patients in each cohort will be monitored closely for safety and drug toxicity.

The second part of the study has a randomised component where patients will receive the combination of drugs or pazopanib alone with the aim to determine whether there is an advantage in progression free survival for patients that receive pazopanib and fosbretabulin. This will be monitored by RECIST.

Conditions

Ovarian Neoplasms; Neoplasms, Ovarian; Ovarian Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Phase Ib/II: Fosbretabulin & Pazopanib

Phase Ib:

Fosbretabulin and Pazopanib in combination. Fosbreatabulin dose will be in the range of 45mg/m2- 60 mg/m2 delivered by infusion every week for 3 weeks of a 4 week cycle until disease progression. Pazopanib will be either 600 mg or 800mg taken orally each day of 28 day cycle until disease progression.

The phase II dose of both drugs will be determined by the Phase Ib component which is a dose finding exercise.

Phase II:

Fosbretabulin and Pazopanib in combination. Fosbretabulin 54mg/m2 delivered by infusion every week for 3 weeks of a 4 week for 28 day cycle until disease progression. Pazopanib 600mg taken orally each day for 28 day cycle until disease progression

Group Type: EXPERIMENTAL

Pazopanib

Intervention Type: DRUG

Tyrosine Kinase Inhibitor

Fosbretabulin

Intervention Type: DRUG

Vascular Disrupting Agent

Phase II: Pazopanib

Pazopanib 800mg taken orally each day of 28 day cycle until disease progression

Group Type: ACTIVE_COMPARATOR

Pazopanib

Intervention Type: DRUG

Tyrosine Kinase Inhibitor

Interventions

Pazopanib

Tyrosine Kinase Inhibitor

Intervention Type: DRUG

Fosbretabulin

Vascular Disrupting Agent

Intervention Type: DRUG

Other Intervention Names

Votrient; EU/1/10/628/001; EU/1/10/628/002; Fosbretabulin tromethamine

Eligibility Criteria

Inclusion Criteria

• Advanced, progressive, recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma, which has recurred following at least one platinum-containing regimen.
• Progressive disease according to RECIST 1.1 or GCIG criteria within 3-12 months of completing platinum containing therapy, although this need not be the immediately preceding regimen.
• World Health Organisation (WHO) performance status of 0 or 1 (Appendix 1).
• Measurable disease (RECIST 1.1 (Appendix 2) or Progressive Disease (PD) according to CA125 GCIG criteria with non-measurable disease on CT scan.
• Life expectancy of at least 12 weeks.
• Haematological and biochemical indices within the ranges shown below. These measurements must be performed within one week (Day -7 to Day 1) before the patient receives the first dose of Investigational Medicinal Product (IMP):

• Haemoglobin (Hb) ≥ 90 g/L
• Absolute neutrophil count ≥ 1.5 x 109/L
• Platelet count ≥ 100 x 109/L
• Serum potassium within normal range
• Bilirubin ≤ 1.5 x upper limit of normal (ULN)
• Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) ≤ 2.5 x ULN unless raised due to hepatic metastatic disease in which case up to 5 x ULN is permissible
• Either: Calculated creatinine clearance ≥ 40 mL/min (uncorrected value) Or: Isotope clearance measurement ≥ 40 mL/min (corrected)
• Activated partial thromboplastin time (aPTT) ≤ 1.2 x ULN
• Prothrombin Time (PT) or International normalised ratio (INR) ≤ 1.3 x ULN
• Urine protein dipstick of less than or equal to 2+, or if 2+ or greater the patient must have a 24 hour urinary protein value of less than 2 g.
• Clinically euthyroid.
• Aged 18 years or over at the time of consent.
• Written (signed and dated) informed consent and capable of co-operating with treatment and follow-up.
• Patients can have received bevacizumab prior to trial entry providing that the last dose was administered at least 6 months before the first dose of IMP.

Exclusion Criteria

• Radiotherapy, surgery or tumour embolisation within 28 days before the first dose of IMP
• Endocrine therapy, immunotherapy or chemotherapy during the previous four weeks (six weeks for nitrosoureas, Mitomycin-C and six weeks for investigational medicinal products) before the first dose of IMP.
• Ongoing grade ≥ 2 toxic manifestations of previous treatments. Exceptions to this are alopecia or certain Grade 1 toxicities, which in the opinion of the Chief and Principal Investigators should not exclude the patient; and grade 1 or 2 neurotoxicity considered to be due to paclitaxel.
• Female patients who are able to become pregnant (or are already pregnant or lactating). Those who have a negative serum or urine pregnancy test before enrolment and agree to use two highly effective forms of contraception (oral, injected or implanted hormonal contraception and condom, have an intra-uterine device and condom, diaphragm with spermicidal gel and condom) for four weeks before entering the trial, during the trial and for six months afterwards are considered eligible.
• Major thoracic or abdominal surgery from which the patient has not yet recovered.
• At high medical risk because of non-malignant systemic disease including active uncontrolled infection.
• Known to be serologically positive for hepatitis B, hepatitis C or human immunodeficiency virus (HIV).
• History of any of the following cardiovascular conditions within the last six months:

• Coronary revascularisation (percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG))
• Acute coronary syndrome (myocardial infarction (MI), unstable angina)
• Symptomatic peripheral vascular disease
• Class III or IV congestive heart failure, as defined by the New York Heart Association (NYHA) (Appendix 4)
• Patients who have sustained hypertension, defined as a systolic blood pressure (SBP) of > 140 mm Hg or diastolic blood pressure (DBP) of > 90 mm Hg, on three occasions.
• ECG with evidence of clinically significant abnormalities.
• Patients with a QTc> 480ms or taking any drug known to prolong the QTc interval that cannot be stopped for the duration of the trial (Appendix 4).
• Patients with pathologic bradycardia (<60 b/m in non-athletes), heart block (excluding first-degree block, being PR interval prolongation only).
• History of cerebrovascular accident (including transient ischaemic attack (TIA)), pulmonary embolism or untreated deep vein thrombosis (DVT) within the past six months. Patients with recent DVT or pulmonary embolism who have been treated with therapeutic anti-coagulant agents for at least six weeks will be eligible, provided their INR (if taking oral anti-coagulants) has been stable for this period of time.
• History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, except for individuals who have previously treated CNS metastases, are asymptomatic and have had no requirement for steroids or anti-convulsant medication for six months prior to the first dose of IMP.
• Clinically significant abnormalities that may increase the risk of gastrointestinal bleeding or perforation, including but not limited to:

• Bleeding: Active peptic ulcer disease, known intraluminal metastatic lesions with risk of bleeding, Inflammatory bowel disease (Crohn's disease, ulcerative colitis);
• Perforation: History of abdominal fistula or large pelvic mass; gastrointestinal perforation or intra-abdominal abscess within four weeks prior to first dose of IMP; previous bowel surgery which is judged by the investigator to increase significantly the risk of gastrointestinal complications from trial treatment
• Evidence of active bleeding or bleeding diathesis.
• Transfusion within one week prior to first dose of IMP.
• Known endobronchial lesions and/or lesions infiltrating major pulmonary vessels.
• Clinically significant haemoptysis, within eight weeks before the first dose of IMP.
• Previous treatment with pazopanib.
• Any participant that is participating in (or plans to participate in) another interventional clinical trial, whilst taking part in this Phase Ib/II study of fosbretabulin and pazopanib. Participation in an observational trial would be acceptable.
• Any other condition which in the Investigator's opinion would not make the patient a good candidate for the clinical trial.
• Current malignancies of other types, with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri and basal or squamous cell carcinoma of the skin and no evidence of recurrence of other malignancy for at least 2 years.
• Hypersensitivity to Pazopanib or any of it's excipients

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Novartis

INDUSTRY

Sponsor Role: collaborator

Mateon Therapeutics

INDUSTRY

Sponsor Role: collaborator

East and North Hertfordshire NHS Trust

OTHER_GOV

Sponsor Role: collaborator

The Christie NHS Foundation Trust

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Gordon Jayson

Role: STUDY_CHAIR

The Christie National Health Service (NHS) Foundation Trust

Gordon Rustin

Role: STUDY_CHAIR

East and North Herts NHS Trust

Locations

Royal United Hospital Bath NHS Trust

Bath, , United Kingdom

City Hospital

Birmingham, , United Kingdom

University Hospitals Bristol NHS Foundation Trust

Bristol, , United Kingdom

University Collage London Hospitals NHS Foundation Trust

London, , United Kingdom

The Royal Marsden NHS Foundation Trust

London, , United Kingdom

The Christie NHS Foundation Trust

Manchester, , United Kingdom

Clatterbridge Centre for Oncology NHS Foundation Trust

Metropolitan Borough of Wirral, , United Kingdom

Mount Vernon Cancer Centre (East and North Herts NHS Trust)

Middlesex, , United Kingdom

Freeman Hospital (Newcastle-upon-Tyne Hospitals NHS Foundation Trust)

Newcastle upon Tyne, , United Kingdom

Oxford Radcliffe Hospitals NHS Trust

Oxford, , United Kingdom

Countries

United Kingdom

References

Morgan RD, Banerjee S, Hall M, Clamp AR, Zhou C, Hasan J, Orbegoso C, Taylor S, Tugwood J, Lyon AR, Dive C, Rustin GJS, Jayson GC. Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial. Gynecol Oncol. 2020 Mar;156(3):545-551. doi: 10.1016/j.ygyno.2020.01.005. Epub 2020 Jan 10.

Reference Type: DERIVED

PMID: 31932108 (View on PubMed)

Related Links

http://www.christie.nhs.uk/

Christie NHS website

Other Identifiers

2013-005471-40

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

13_DOG01_119

Identifier Type: -

Identifier Source: org_study_id