TAILORx Tissue Bank

NCT ID: NCT02050750

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Study Completion Date

2031-11-30

Brief Summary

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This is an exploratory, translational, non-interventional and multi-centre biobank. The aim of the development of such a biobank is to identify potential biomarkers that are indicative of disease relapse.

Detailed Description

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The primary objective is to develop a biobank, tissue microarrays (TMAs) and full face sections, which will be used to identify candidate/ novel biomarkers prognostic for disease relapse and predictive for endocrine and/or chemotherapy resistance.

The secondary objectives are:

* To validate emerging signatures/biomarkers identified.
* To develop new assays for the breast cancer clinic.

Conditions

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Breast Cancer

Keywords

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Must have registered with the ICORG 06-31 TAILORx trial

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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TAILORx ICORG 06-31

Patients must have participated in TAILORx ICORG 06-31, participated in trial arms, and have adequate tumour tissue available

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients that were registered with the ICORG 06-31 TAILORx trial and participated in trial arms
* Patients with adequate tumor tissue available
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Cancer Trials Ireland

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Bons Secours Hospital

Cork, , Ireland

Site Status

Cork University Hospital

Cork, , Ireland

Site Status

Letterkenny General Hospital

Donegal, , Ireland

Site Status

Adelaide and Meath National Children's Hospital Tallaght

Dublin, , Ireland

Site Status

St Vincent Universtiy Hospital

Dublin, , Ireland

Site Status

St James Hospital

Dublin, , Ireland

Site Status

Beaumont Hospital

Dublin, , Ireland

Site Status

Mater Misericordiae University Hospital

Dublin, , Ireland

Site Status

Galway University Hospital

Galway, , Ireland

Site Status

Midwestern Regional Hospital

Limerick, , Ireland

Site Status

Sligo General Hosptial

Sligo, , Ireland

Site Status

Waterford Regional Hospital

Waterford, , Ireland

Site Status

Countries

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Ireland

References

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Lynch SM, Russell NM, Barron S, Wang CA, Loughman T, Dynoodt P, Fender B, Lopez-Ruiz C, O'Grady A, Sheehan KM, Fay J, Amberger-Murphy V, Saha A, Klinger R, Gonzalez CA, Al-Attar N, Rahman A, O'Leary D, Lanigan FT, Bracken AP, Crown J, Kelly CM, O'Connor DP, Gallagher WM. Prognostic value of the 6-gene OncoMasTR test in hormone receptor-positive HER2-negative early-stage breast cancer: Comparative analysis with standard clinicopathological factors. Eur J Cancer. 2021 Jul;152:78-89. doi: 10.1016/j.ejca.2021.04.016. Epub 2021 Jun 2.

Reference Type DERIVED
PMID: 34090143 (View on PubMed)

Other Identifiers

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ICORG 12-30

Identifier Type: -

Identifier Source: org_study_id