Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1178 participants
OBSERVATIONAL
2014-02-28
2019-06-30
Brief Summary
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Detailed Description
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Gastric carcinogenesis is a multi-factorial process that includes environmental, socioeconomic, and lifestyle factors. Many of risk factors, including dietary factors, chronic atrophic gastritis, intestinal metaplasia, and H. pylori infection, alcohol consumption, and aspirin have been investigated. Although the specific correlation between serum cholesterol and gastric cancer is not fully understood, inverse relationships have been observed between serum total cholesterol (TC) levels and cancer, and recent analyses of randomized controlled trials showed significant inverse associations between high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) and the risk of incident cancers. Lower lipoprotein cholesterol in cancer patients may be due to the enhanced activity of the lipoprotein cholesterol receptor pathway and to the increased demand for cholesterol during tumor development and lymphatic spread. Some suggested that the preexisting tumor might have resulted in low serum cholesterol, which is called "preclinical cancer effect" or "unsuspected sickness". In another study, LDL-C has been reported to affect host immune system cells.
In our previous study, investigators found that serum HDL-C and LDL-C levels were associated with the risk, resectability, and prognosis of gastric cancer. There are several cohort studies reported that low serum cholesterol levels are associated with incident cancer, including gastric cancer. However, most studies regarding the serum cholesterol and gastric cancer investigated gastrectomized patients, and showed the association between low serum cholesterol levels and lymph node metastasis or submucosal invasion. Furthermore, there are only few studies evaluated the association between LDL-C of apolipoproteins and gastric cancer. Therefore investigators conducted nested case-control study to investigate the association between serum cholesterol levels including TC, HDL-C, LDL-C, triglyceride (TG), apolipoproteins and gastric neoplasm. In addition, further analyses were performed to evaluate the possible role of the serum cholesterol as a predictor for the differentiation and prognosis of gastric neoplasm.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Gastric cancer
No intervention
No intervention
No intervention will be needed.
Interventions
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No intervention
No intervention will be needed.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Subjects who do not want to be enrolled this study
ALL
No
Sponsors
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Asan Medical Center
OTHER
Responsible Party
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Ji Yong Ahn
Professor
Principal Investigators
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Hwoon-Yong Jung, M.D., PhD.
Role: STUDY_CHAIR
Asan Medical Center
Locations
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Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Ji Yong Ahn, M.D., PhD.
Role: primary
Other Identifiers
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KCHUGRFG1312
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
AMC-1312
Identifier Type: -
Identifier Source: org_study_id