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MIDNOR-TIA - a Study of 600 Patients With Transient Ischemic Attack

NCT ID: NCT02038725

Last Updated: 2021-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

584 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2015-07-31

Brief Summary

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Patients with a transient ischemic attack (TIA) are at high risk of stroke. Rapid assessment and treatment can reduce the risk. Several international guidelines recommend a test, the ABCD2 score, to identify TIA patients with low and high risk for stroke. The main purpose of this study is to investigate stroke risk after TIA in both short (1 week) and long term (3 months/1 year), and to assess whether the ABCD2 score ('Age, blood pressure, clinical features, duration of TIA, diabetes score) is an adequate tool for predicting stroke risk. Secondary aims are to explore whether adopting imaging modalities (ultrasound, MRI) and biological markers of blood into a risk score could improve the predictive value of the ABCD2 score and still be feasible in a daily clinical practice. Further on overall risk factors in TIA patients, and the incidence of other vascular events will be studied. A substudy designed as a randomised controlled trial evaluates pharmaceutical counseling in a subset of participants. Cost-benefit analysis, and a long-term follow-up (5 years) is planned.

Detailed Description

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Conditions

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Ischemic Attack, Transient Stroke

Keywords

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Risks Risk Factors ABCD2 score Predictive Value of Tests Risk Assessment Severity of Illness Index Decision Support Techniques

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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TIA in last 2 weeks

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Probable or possible transient ischemic attack
* Residing in Central Norway
* Examined within 2 weeks after the onset of symptoms
* Modified Rankin Scale 3 or less and living at home
* Informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Olavs Hospital

OTHER

Sponsor Role collaborator

Helse Midt-Norge

OTHER

Sponsor Role collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bent Indredavik, PhD, Prof

Role: STUDY_DIRECTOR

Norwegian University of Science and Technology

Locations

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Ålesund Sykehus

Ålesund, , Norway

Site Status

Kristiansund Sykehus

Kristiansund, , Norway

Site Status

Levanger Sykehus

Levanger, , Norway

Site Status

Molde Sykehus

Molde, , Norway

Site Status

Namsos Sykehus

Namsos, , Norway

Site Status

Orkdal Sykehus

Orkanger, , Norway

Site Status

St Olavs Hospital

Trondheim, , Norway

Site Status

Volda Sykehus

Volda, , Norway

Site Status

Countries

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Norway

References

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Ildstad F, Ellekjaer H, Fjaertoft H, Indredavik B. MIDNOR TIA - a prospective cohort study of 586 patients, baseline data from a subgroup of 363 patients examined with diffusion-weighted imaging. International Journal of Stroke 10(suppl 2):242, 2015 (Meeting Abstract ESOC-1527)

Reference Type RESULT

Ildstad F, Ellekjaer H, Wethal T, Lydersen S, Sund JK, Fjaertoft H, Schuler S, Horn JW, Brathen G, Midtsaether AG, Morsund AH, Lillebo ML, Seljeseth YM, Indredavik B. Stroke risk after transient ischemic attack in a Norwegian prospective cohort. BMC Neurol. 2019 Jan 3;19(1):2. doi: 10.1186/s12883-018-1225-y.

Reference Type RESULT
PMID: 30606138 (View on PubMed)

Ildstad F, Ellekjaer H, Wethal T, Lydersen S, Fjaertoft H, Indredavik B. ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk. Stroke Res Treat. 2021 Feb 25;2021:8845898. doi: 10.1155/2021/8845898. eCollection 2021.

Reference Type RESULT
PMID: 33708373 (View on PubMed)

Other Identifiers

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2012/1224

Identifier Type: -

Identifier Source: org_study_id