Efficacy of Bronchial Thermoplasty in Korean

NCT ID: NCT02031263

Last Updated: 2014-08-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2015-02-28

Brief Summary

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The investigators will find out if bronchial thermoplasty shows efficacy in reducing acute exacerbation and improving quality of life for uncontrolled asthma in Korea through this research. US FDA approved this procedure and CE mark was taken in Europe. Many procedure was performed in Western countries.

Korean FDA have approved this procedure in 2013. However, no procedure was performed in Korea, and the data is rare in Asian countries. In this study, investigators will examine the efficacy of this procedure in Korean asthmatics.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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thermoplasty group

Check on the quality of life, emergency room uses, and sudden progress of the disease of the patients before and after the treatment by using bronchial thermoplasty system by using paired t test.

Group Type EXPERIMENTAL

bronchial thermoplasty system

Intervention Type PROCEDURE

Check on the quality of life, emergency room uses, and sudden progress of the disease of the patients before and after the treatment by using bronchial thermoplasty system by using paired t test.

Interventions

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bronchial thermoplasty system

Check on the quality of life, emergency room uses, and sudden progress of the disease of the patients before and after the treatment by using bronchial thermoplasty system by using paired t test.

Intervention Type PROCEDURE

Other Intervention Names

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ALAIR

Eligibility Criteria

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Inclusion Criteria

* 1\) Eighteen-year-old or older
* 2\) Patients whose asthma is not controlled with more than three months of using high dose inhaled steroids and long acting β2-agonists
* 3\) Patients with pre-bronchodilator FEV1 is between sixty and eighty-five%
* 4\) Patients who do not improve through continuous drug uses.

Exclusion Criteria

* 1\) Presence of a pacemaker, internal defibrillator, or other implantable electronic devices,
* 2\) Known sensitivity to medications required to perform bronchoscopy, including lidocaine, atropine, and benzodiazepines.
* 3\) Patients previously treated with the Alair System should not be retreated in the same area(s). No clinical data are available studying the safety and/or effectiveness of repeat treatments.
* 4)Active respiratory infection
* 5\) Asthma exacerbation or changing dose of systemic corticosteroids for asthma (up or down) in the past 14 days.
* 6\) Known coagulopathy.
* 7\) As with other bronchoscopic procedures, patients should stop taking anticoagulants, antiplatelet agents, aspirin and NSAIDS before the procedure with physician guidance.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Sei Won Lee

Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sei Won Lee, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Locations

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Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Sei Won Lee, MD

Role: CONTACT

+82-2-3010-3990

Facility Contacts

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Sei Won Lee, MD

Role: primary

+82-2-3010-3990

Other Identifiers

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Thermoplasty-Br

Identifier Type: -

Identifier Source: org_study_id

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