Automatic Administration of Oxygen During Respiratory Distress

NCT ID: NCT02027181

Last Updated: 2014-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

190 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2014-10-31

Brief Summary

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Aim: The purpose of this study is to evaluate the use feasibility of FreeO2 so as to deliver automatically oxygen in the emergency department in a patient population admitted for acute respiratory failure.

Hypothesis: The principal hypothesis is that FreeO2 is possible and well-accepted by nurses and medical personnel and there are advantages to use this system. In comparison with the common oxygen delivery (the rotameter), the hypothesis is that FreeO2 system will make for a better control of the oxygen saturation in function of designed target, reducing the desaturation time and hyperoxia. We think that oxygen weaning will be faster than classical way if it is automated. In addition, FreeO2 could reduce the number of intervention by nurse personnel.

Detailed Description

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Conditions

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Acute Respiratory Distress Syndrome Hypoxemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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device FreeO2

Automatic adjustment of oxygen

Group Type EXPERIMENTAL

Device FreeO2 v2.0

Intervention Type DEVICE

* Automatic adjustment of oxygen through the "Free O2" device.
* "FreeO2" device in mode medical data collecting(SpO2,EtCO2...).

Manual oxygenation

Manual adjustment of oxygen

Group Type ACTIVE_COMPARATOR

Device FreeO2 v2.0

Intervention Type DEVICE

* Manual adjustment of oxygen without the assistance of the "FreeO2" device.
* Only "FreeO2" device in mode medical data collecting(SpO2,EtCO2...).

Interventions

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Device FreeO2 v2.0

* Automatic adjustment of oxygen through the "Free O2" device.
* "FreeO2" device in mode medical data collecting(SpO2,EtCO2...).

Intervention Type DEVICE

Device FreeO2 v2.0

* Manual adjustment of oxygen without the assistance of the "FreeO2" device.
* Only "FreeO2" device in mode medical data collecting(SpO2,EtCO2...).

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Admission to the emergency for respiratory disease (or cardiac - acute pulmonary edema)justifying an oxygen administration to over 3 L / min to maintain a SpO2 ≥ 92%.
* Inclusion within a time less than two hours after the start of the oxygen at the emergency.
* Patient consent,or a close.

Exclusion Criteria

* Necessity of an oxygen flow exceeds 15 L / min to maintain a SpO2 higher than 92%.
* Criteria of gravity justifying immediately a different technique of ventilatory support:
* Disturbance of consciousness with a Glasgow Coma Score ≤ 12
* Serious ventricular rhythm disorders
* Hemodynamic instability (SBP \<80mmHg or recourse to vasopressors)
* Cardiac or respiratory arrest
* pH \< 7.35 and PaCO2 \> 55 mm Hg
* Necessity of a urgent surgery, or coronary revascularization
* Age \<18 years
* Pregnant women, lactating
* Patient not relevant
* Unavailability of the prototype FreeO2
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ministry of Health, France

OTHER_GOV

Sponsor Role collaborator

University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Erwan L'HER

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Brest

Locations

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Hopital Hotel Dieux de Levis

Lévis, Quebec, Canada

Site Status

Institut universitaire de Cardiologie et de Pneumologie de Québec

Québec, Quebec, Canada

Site Status

HIA Clermont Tonnerre

Brest, , France

Site Status

Brest, University Hospital

Brest, , France

Site Status

Countries

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Canada France

References

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L'Her E, Dias P, Gouillou M, Riou A, Souquiere L, Paleiron N, Archambault P, Bouchard PA, Lellouche F. Automatic versus manual oxygen administration in the emergency department. Eur Respir J. 2017 Jul 20;50(1):1602552. doi: 10.1183/13993003.02552-2016. Print 2017 Jul.

Reference Type DERIVED
PMID: 28729473 (View on PubMed)

Other Identifiers

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RB 10-071 FreeO2-Hypox

Identifier Type: -

Identifier Source: org_study_id