RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Study Completion Date

2019-06-30

Brief Summary

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Hypothesis: We hypothesize that RNAseq will allow us to learn more about the causative agents of necrotizing soft tissue infections (NSTI) and risk factors involved in acquiring these devastating infections

Tissue biopsies will be obtained from consented patients admitted with NSTI. Biopsies will be used for standard clinical analysis of bacterial species present or stored for later RNA sequencing. RNA sequencing will identify bacteria that are present within the infection site that may not be detected using standard culture techniques as well as reveal bacterial gene expression profiles within the NSTI site. Medical charts will also be reviewed for basic patient information as well as wound care management practices. We hope to identify bacterial species commonly present in these types of infections as well as risk factors predisposing individuals to NSTI's.

Detailed Description

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Conditions

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Necrotizing Soft Tissue Infections

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient or LAR agrees to the procedure and signs informed consent form
* Patient is at least 18 yrs of age
* Patient has been diagnosed with an NSTI

Exclusion Criteria

* Patient not willing to undergo additional tissue biopsies for RNA sequencing analysis

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kendra Rumbaugh, PhD

Role: PRINCIPAL_INVESTIGATOR

Texas Tech University Health Sciences Center

Locations

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Texas Tech University Health Sciences Center/University Medical Center

Lubbock, Texas, United States

Site Status

University Medical Center