Functional Bioactive Supplement Effect in Lost Weight Treatment

NCT ID: NCT02024425

Last Updated: 2015-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

109 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-01-31

Brief Summary

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The purpose this study is to evaluate the therapeutic effect of a functional bioactive supplement associated with a hypocaloric equilibrated diet to treat obese and overweight individuals. The functional bioactive supplement, containing antioxidant extracted from rosemary, oligosaccharides derived from lactulose and bioactive peptides, was developed to satiety control, improves of anti-inflammatory response and antioxidant defense mechanisms as well as to weight loss.

Detailed Description

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A randomized, parallel, double-blind, controlled was performed to evaluate the therapeutic effect of a functional bioactive supplement associated with a hypocaloric equilibrated diet to treatment of obesity and overweight.

Women aged between 18 and 65 years with obesity and overweight diagnosis (IMC \>25\<35 kg/m2) were included in the study. The clinical trial will be performed in the Clinical Nutrition Department of La Paz University Hospital, in Madrid. All of the volunteers will receive a dietetic treatment with 1500 Kcal/day and physical activity recommendations during the study.

Conditions

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Obesity and Overweight

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Functional bioactive supplement

The functional bioactive supplement is composed of antioxidant extracted from rosemary, oligosaccharides derived from lactulose and bioactive peptides. It will be used for obese and overweight treatment

Group Type ACTIVE_COMPARATOR

Functional bioactive supplement

Intervention Type DIETARY_SUPPLEMENT

1,25g of antioxidant extracted from rosemary, 18g of oligosaccharides derived from lactulosa and 1,25g of bioactive peptides

Maltodextrin and saccharose

The control supplement is composed of maltodextrin and saccharose . It has no effect for obese and overweight treatment

Group Type PLACEBO_COMPARATOR

Control supplement

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Functional bioactive supplement

1,25g of antioxidant extracted from rosemary, 18g of oligosaccharides derived from lactulosa and 1,25g of bioactive peptides

Intervention Type DIETARY_SUPPLEMENT

Control supplement

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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antioxidant, oligosaccharides and bioactive peptides

Eligibility Criteria

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Inclusion Criteria

* Women from 45 to 75 years old;
* Overweight (IMC ≥25\<30 Kg/m2) or obese (IMC ≥30\<35 Kg/m2) volunteers
* Signed informed consent.

Exclusion Criteria

* Subjects with drug consumption (lipid-lowering, oral hypoglycemic agents and / or hypertensive) in less than one month period;
* Subjects with Diabetes Mellitus insulin dependent;
* Individuals that stop smoking in the next 12 weeks (during the study);
* Subjects with increased alcohol consumption (\> 1 glass of vine);
* Subjects that consume drugs, vitamins, minerals, prebiotics or/and probiotics that interfere with the body's response to the extracts in the 2 weeks before to baseline;
* Subjects with drugs consumption special diet due to disease as celiac disease, chronic renal failure, etc;
* Subjects with disorders associated with eating behaviour;
* Subjects with drugs or supplements consumption to weight lost;
* Subjects with physical problems complying with the recommendations of physical activity and diet indicated;
* Subjects who refuse to perform the indicated dietary changes throughout the study;
* Subjects with diseases that could be involucrate in weight lost (not controlled hypothyroidism, serious psychiatric illness, etc.);
* Subjects with mental disease or low cognitive function;
* Subjects with severe diseases (hepatic, kidney, cancer…);
* Pregnant women or lactating;
* Subjects with physical problems complying with the recommendations of physical activity.
* Subjects with intensive physical activity;
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Instituto de Investigación Hospital Universitario La Paz

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Carmen Gomez Candela, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital Universitario La Paz

Locations

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Hospital Universitario La Paz

Madrid, Madrid, Spain

Site Status

Countries

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Spain

Related Links

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http://www.idipaz.es

Institute for Health Research IdiPAZ

Other Identifiers

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ALIBIRDII

Identifier Type: -

Identifier Source: org_study_id