Corneal Epithelial and Stromal Thickness Distribution in Keratoconus
NCT ID: NCT02023619
Last Updated: 2019-04-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
40 participants
OBSERVATIONAL
2013-07-31
2013-09-30
Brief Summary
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Study Hypothesis: SD-OCT provides necessary details about the distribution of corneal epithelial and stromal thicknesses for identification of a pattern characteristic for early keratoconus.
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Detailed Description
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Methodology: SD-OCT corneal scans of 20 eyes with keratoconus (group 1) and 20 healthy eyes with \> 2 diopters (D) of corneal astigmatism as controls (group 2) are studied. Keratoconus patients referred to the Eye Dpt. of the University Hospital North Norway for CXL (Corneal collagen cross-linking)- treatment and healthy subjects seeking preoperative evaluation for refractive surgery at SynsLaser® Kirurgi AS Tromsø clinic are examined by corneal SD-OCT as a part of their routine examination. Analysis of their SD-OCT corneal scans is used for the purpose of this study.Two cross-sectional meridional corneal profiles (along steepest and flattest meridians, located by a Scheimpflug-based corneal topography) for each individual are obtained by using a RTVue100® (Optovue Inc. Fremont, California, USA), 26000-Hz SD-OCT across the central 6mm diameter of the cornea.
Conditions
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Study Design
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CASE_CROSSOVER
RETROSPECTIVE
Study Groups
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Keratoconus
Eyes with confirmed keratoconus diagnosis
No interventions assigned to this group
Astigmatism >2.0 D
Healthy eyes with astigmatism \>2.0 D
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Astigmatism group: Healthy eyes with astigmatism of \>2.0 D
Exclusion Criteria
* Astigmatism group: No signs of keratoconus
18 Years
ALL
Yes
Sponsors
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The Research Council of Norway
OTHER
SynsLaser Kirurgi AS
OTHER
Responsible Party
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Aleksandar Stojanovic
Medical director of SynsLaser Surgery AS
Principal Investigators
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Aleksandar Stojanovic, MD
Role: PRINCIPAL_INVESTIGATOR
SynsLaser Kirurgi AS
Locations
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SynsLaser Kirurgi AS
Tromsø, Troms, Norway
Countries
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References
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Zhou W, Stojanovic A. Comparison of corneal epithelial and stromal thickness distributions between eyes with keratoconus and healthy eyes with corneal astigmatism >/= 2.0 D. PLoS One. 2014 Jan 28;9(1):e85994. doi: 10.1371/journal.pone.0085994. eCollection 2014.
Other Identifiers
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SL 1
Identifier Type: OTHER
Identifier Source: secondary_id
REK NORD 2013/758
Identifier Type: -
Identifier Source: org_study_id
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