Absolute Bioavailability of Lu AE58054 in Healthy Subjects

NCT ID: NCT02019394

Last Updated: 2014-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-31

Brief Summary

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To determine the absolute bioavailability of the Lu AE58054 tablet formulation at steady state

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Lu AE58054

Group Type EXPERIMENTAL

Lu AE58054

Intervention Type DRUG

Oral dosing: 90 mg Lu AE58054 as a single dose once and after a 3 days washout period, once daily for 7 days.

Intravenous dosing: 90 μg/not more than (NMT) 1000 nCi/37 kBq 14C-Lu AE58054 for intravenous infusion once on Day 10.

Interventions

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Lu AE58054

Oral dosing: 90 mg Lu AE58054 as a single dose once and after a 3 days washout period, once daily for 7 days.

Intravenous dosing: 90 μg/not more than (NMT) 1000 nCi/37 kBq 14C-Lu AE58054 for intravenous infusion once on Day 10.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women aged between 21-55 years (inclusive) and with an BMI in the range 18.5 to 32 kg/m2 (minimum weight 60 kg for men and 55 kg for women).
* The subjects CYP2D6 genotype must be determined before inclusion into the study.
* Women must not be pregnant or lactating.

Exclusion Criteria

* The subject is, in the opinion of the investigator, unlikely to comply with the protocol or is unsuitable for any reason.
Minimum Eligible Age

21 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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H. Lundbeck A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Email contact via H. Lundbeck A/S

Role: STUDY_DIRECTOR

[email protected]

Locations

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GB803

Nottingham, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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2012-005646-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

14915A

Identifier Type: -

Identifier Source: org_study_id

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