Bag Mode BreathID Hp Validation Versus Endoscopy in Detection of Helicobacter Pylori

NCT ID: NCT02010112

Last Updated: 2022-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

193 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Study Completion Date

2015-02-28

Brief Summary

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A new method of breath collection for testing for Helicobacter Pylori infection has been developed by Exalenz. In this study, it will be compared to the gold standard- endoscopy results to prove its accuracy.

Detailed Description

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This study will validate a breath collection method by comparing a newly developed breath test kit, IDkit:Hp™ TWO using breath collection bags, to congruent biopsy results (a composite reference standard by analyzing specimens with microbial culture, histological examination and rapid urease test- RUT) in detecting H.Pylori

Conditions

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Helicobacter Pylori Infection

Keywords

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H.Pylori

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Investigators

Study Groups

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Initial Diagnosis Cohort

Subjects with clinical indication of H.pylori infection will undergo breath test compared to routine clinical standard of care- endoscopy

Group Type EXPERIMENTAL

Breath Test Collection bags

Intervention Type OTHER

Breath Collection bags will be used to collect breath of subjects before and after ingestion of 13-C breath test substrate

Interventions

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Breath Test Collection bags

Breath Collection bags will be used to collect breath of subjects before and after ingestion of 13-C breath test substrate

Intervention Type OTHER

Other Intervention Names

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IDKit Two

Eligibility Criteria

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Inclusion Criteria

* Present with clinical indication of H. pylori and candidate for upper endoscopy
* Have the ability and willingness to sign the Informed Consent Form for initial diagnosis cohort
* Naive to treatment in the past 18 months
* No known H.pylori status (no conclusive test results within last 6 months)

Exclusion Criteria

* Participation in other interventional trials
* Antibiotics and/or Bismuth preparations within four (4) weeks prior to breath test
* PPI (proton pump inhibitors) or H2 blockers within two (2) weeks prior to breath test
* Pregnant or breastfeeding women
* Allergy to test substrates
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Meridian Bioscience, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Melina Arazy, M.D.

Role: STUDY_DIRECTOR

VP of clinical affairs, Exalenz

Locations

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Digestive Disease Associates, PA

Baltimore, Maryland, United States

Site Status

Metropolitan Gastroenterology Group

Chevy Chase, Maryland, United States

Site Status

Henry Ford Health System

Detroit, Michigan, United States

Site Status

Digestive Health Care

Ocean Springs, Mississippi, United States

Site Status

Montefiore Hospital

The Bronx, New York, United States

Site Status

Omega Medical Research

Warwick, Rhode Island, United States

Site Status

Clinical Research Solutions

Jackson, Tennessee, United States

Site Status

JM Research

Houston, Texas, United States

Site Status

Bon Secours Health System

Richmond, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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DM-MPBA-0813

Identifier Type: -

Identifier Source: org_study_id