A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients

NCT ID: NCT02009397

Last Updated: 2021-11-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-02-29
• Study Completion Date: 2016-11-30

Brief Summary

The purpose of this study is to test the combination of Ipilimumab and GM-CSF. Both ipilimumab and GM-CSF are intended to work with the body's own immune system to attack melanoma cells in the body. This study will also demostrate how safe the combined drugs are when used to treat patients with Stage 3 or Stage 4 melanoma (metastatic melanoma), which cannot be removed by surgery.

Conditions

Metastatic Melanoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Ipilimumab and GM-CSF

IV ipilimumab followed by subcutaneous GM-CSF, for up to 4 cycles

Group Type: EXPERIMENTAL

Ipilimumab

Intervention Type: DRUG

GM-CSF

Intervention Type: DRUG

Interventions

Ipilimumab

Intervention Type: DRUG

GM-CSF

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients may be entered in the study only if they meet all of the following criteria.

1. Male or female patients ≥18 years of age;

2. Patients with histological confirmed melanoma (Stage IIIC or Stage IV, American Joint Commission on Cancer);

3. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 to 2;

4. Life expectancy ≥3 months;

5. At least 1 site of radiographically measurable disease by immune-related response criteria (irRC);

6. Adequate hematologic, renal, and liver function as defined by laboratory values performed within 42 days prior to initiation of dosing:

• Absolute neutrophil count (ANC) ≥1.0 x 109/L;
• Platelet count ≥50 x 109/L;
• Hemoglobin ≥8 g/dL;
• Serum creatinine ≤3 x upper limit of normal (ULN)
• Total serum bilirubin ≤2 x ULN;
• Serum aspartate transaminase (AST/SGOT) or serum alanine transaminase (ALT/SGPT) ≤2x ULN, and ≤3 x ULN if liver metastases are present.

7. Fertile males should use an effective method of contraception during treatment and for at least 3 months after completion of treatment, as directed by their physician;

8. Pre-menopausal females and females <2 years after the onset of menopause should have a negative pregnancy test at Screening. Pre-menopausal females must agree to use an acceptable method of birth control from the time of the negative pregnancy test up to 90 days after the last dose of study drug. Females of non-childbearing potential may be included if they are either surgically sterile or have been postmenopausal for ≥1 year;

9. Before study entry, written informed consent must be obtained from the patient prior to performing any study-related procedures.

Exclusion Criteria

• Patients will not be entered in the study for any of the following:

1. Treatment with Denileukin Diftitox within 42 days prior to the start of Ipilimumab;

2. Prior treatment with Ipilimumab;

3. Known hypersensitivity to Ipilimumab or any of its components

4. Received radiotherapy for non CNS disease within the 2 weeks prior to commencing study treatment or have not recovered from side effects of all radiation-related toxicities to Grade ≤1, except for alopecia;

5. Steroids within one week prior to initiation of Ipilimumab.

6. Pre-existing autoimmune colitis.

7. Patients with an allograft requiring immunosuppression;

8. Known positive human immunodeficiency virus (HIV)

9. Pregnant, breast-feeding, or refusing double barrier contraception, oral contraceptives, or avoidance of pregnancy measures;

10. Have any other uncontrolled infection or medical condition that could interfere with the conduct of the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

James Graham Brown Cancer Center

OTHER

Sponsor Role: collaborator

University of Louisville

OTHER

Sponsor Role: lead

Responsible Party

Jason Chesney

Director, James Graham Brown Cancer Center

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jason Chesney, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Louisville

Locations

James Graham Brown Cancer Center

Louisville, Kentucky, United States

Countries

United States

Other Identifiers

BCC-MEL-11-02 (Ipi2)

Identifier Type: -

Identifier Source: org_study_id