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Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Vascular Function

NCT ID: NCT02007304

Last Updated: 2013-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Brief Summary

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The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Herbs

participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training

Group Type EXPERIMENTAL

Eccentric exercise training

Intervention Type BEHAVIORAL

12 weeks of lower leg eccentric training

Placebo

parcipants in this group will take placebo capsule containing microcrystalline cellulose

Group Type PLACEBO_COMPARATOR

Eccentric exercise training

Intervention Type BEHAVIORAL

12 weeks of lower leg eccentric training

Interventions

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Eccentric exercise training

12 weeks of lower leg eccentric training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

-Healthy sedentary adults

Exclusion Criteria

* obesity (BMI \>30 kg/m2)
* smoking within past six months
* hypertension (high blood pressure \>140/90 mmHg)
* personal history of diabetes (fasting blood glucose \>126 mg/dL), heart disease, or other cardiovascular problems
* orthopedic injury that may prevent him or her from completing the exercise
* the use of over-the-counter supplements or vitamins
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hsin-Fu Lin, Ph.D

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University

Locations

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National Taiwan University

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Hsin-Fu Lin, Ph.D.

Role: CONTACT

Phone: +886932873163

Email: [email protected]

Facility Contacts

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Hsin-Fu Lin, Ph.D

Role: primary

References

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Lin HF, Chou CC, Chao HH, Tanaka H. Panax ginseng and Salvia miltiorrhiza supplementation during eccentric resistance training in middle-aged and older adults: A double-blind randomized control trial. Complement Ther Med. 2016 Dec;29:158-163. doi: 10.1016/j.ctim.2016.10.003. Epub 2016 Oct 11.

Reference Type DERIVED
PMID: 27912940 (View on PubMed)

Lin HF, Tung K, Chou CC, Lin CC, Lin JG, Tanaka H. Panax ginseng and salvia miltiorrhiza supplementation abolishes eccentric exercise-induced vascular stiffening: a double-blind randomized control trial. BMC Complement Altern Med. 2016 Jun 6;16:168. doi: 10.1186/s12906-016-1139-4.

Reference Type DERIVED
PMID: 27266702 (View on PubMed)

Other Identifiers

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201112068MIB

Identifier Type: -

Identifier Source: org_study_id