Multiple-dose Pharmacokinetics of Ceftaroline During Continuous and Intermittent Renal Replacement Therapy in Patients Requiring Renal Replacement Therapy
NCT ID: NCT02007122
Last Updated: 2022-04-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
25 participants
INTERVENTIONAL
2013-12-31
2023-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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IRRT
Ceftaroline levels are measured in patients receiving intermittent renal replacement therapy
Ceftaroline in IRRT
Ceftaroline plasma levels will be measured in patients receiving intermittent renal replacement therapy
CRRT
Ceftaroline levels are measured in patients receiving continuous renal replacement therapy
Ceftaroline in CRRT
Plasma levels of ceftaroline will be measured in patients receiving CRRT
Interventions
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Ceftaroline in CRRT
Plasma levels of ceftaroline will be measured in patients receiving CRRT
Ceftaroline in IRRT
Ceftaroline plasma levels will be measured in patients receiving intermittent renal replacement therapy
Eligibility Criteria
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Inclusion Criteria
* Suspected or proven bacterial infection requiring parenteral antibiotic therapy.
* Renal replacement therapy (continuous or intermittent)
Exclusion Criteria
* An expected survival of less than two days.
* Known pregnancy
* Coadministration of valproic acid or probenecid, which cannot be discontinued for the duration of the study
* Ceftaroline as monotherapy for resistent species or fungal infections.
* Other reasons oposing the study participation on the discretion of the investigators
18 Years
ALL
No
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Florian Thalhammer
Univ.-Prof. Dr.
Locations
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Medical University of Vienna
Vienna, , Austria
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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CEFTAROLINE_RRT
Identifier Type: -
Identifier Source: org_study_id
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