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Comparing the Effect of the Water Drinking Test on Intraocular Pressure

NCT ID: NCT02001155

Last Updated: 2016-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-07-31

Study Completion Date

2014-07-31

Brief Summary

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A test that was common in the 1960's and was used to detect primary open angle glaucoma was the water drinking test (patients drank 1 quart of water to stress the fluid drainage mechanism of the eyes. Intraocular pressure was then measured over the next hour). Recently this test has been demonstrated as a predictor of peak eye pressure during the day. The purpose of this study is to compare the results of the water drinking test between eyes that have undergone trabeculectomy and eyes that have undergone tube shunt surgery.

Detailed Description

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Conditions

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Glaucoma

Keywords

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Water drinking test trabeculectomy tube shunt

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Trabeculectomy

Individuals in this group will have undergone a trabeculectomy for the treatment of glaucoma.

Water Drinking Test

Intervention Type PROCEDURE

The Water Drinking test has been identified as a reliable and safe tool to predict maximum intraocular pressure values during a diurnal tension curve and to assess the efficacy of surgical interventions. Participants are asked to drink 10 ml/kg water (or approximately 0.33 ounces of water for every 2.2 pounds of weight or about 2.5 cups for a 150 lb. individual) over 15 minutes. Intraocular pressure is assessed every 15 minutes for one hour.

Tube Shunt

Individuals in this group will have undergone a tube shunt for the treatment of glaucoma.

Water Drinking Test

Intervention Type PROCEDURE

The Water Drinking test has been identified as a reliable and safe tool to predict maximum intraocular pressure values during a diurnal tension curve and to assess the efficacy of surgical interventions. Participants are asked to drink 10 ml/kg water (or approximately 0.33 ounces of water for every 2.2 pounds of weight or about 2.5 cups for a 150 lb. individual) over 15 minutes. Intraocular pressure is assessed every 15 minutes for one hour.

Interventions

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Water Drinking Test

The Water Drinking test has been identified as a reliable and safe tool to predict maximum intraocular pressure values during a diurnal tension curve and to assess the efficacy of surgical interventions. Participants are asked to drink 10 ml/kg water (or approximately 0.33 ounces of water for every 2.2 pounds of weight or about 2.5 cups for a 150 lb. individual) over 15 minutes. Intraocular pressure is assessed every 15 minutes for one hour.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* prior trabeculectomy or tube shunt for the treatment of glaucoma
* age 21-90 years

Exclusion Criteria

* inability to give informed consent
* current ocular infection
* more than 1 prior trabeculectomy, or more than 1 prior tube shunt
* previous refractive surgery
* pregnant women
* heart failure
* renal failure or uncontrolled urine retention
* corneal abnormalities preventing reliable IOP measurement
Minimum Eligible Age

21 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wills Eye

OTHER

Sponsor Role lead

Responsible Party

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Jonathon Myers

Associate Professor, Ophthalmology; Director of Clinical Fellowship

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jonathan Myers, MD

Role: PRINCIPAL_INVESTIGATOR

Wills Eye Hospital

Locations

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Wills Eye Hospital

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

References

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Waisbourd M, Savant SV, Sun Y, Martinez P, Myers JS. Water-drinking test in primary angle-closure suspect before and after laser peripheral iridotomy. Clin Exp Ophthalmol. 2016 Mar;44(2):89-94. doi: 10.1111/ceo.12639. Epub 2015 Nov 10.

Reference Type BACKGROUND
PMID: 26332426 (View on PubMed)

Other Identifiers

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WEH - 10-989E

Identifier Type: -

Identifier Source: org_study_id