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Vascular Function on the First Day After Cardiac Surgery

NCT ID: NCT02001090

Last Updated: 2017-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Study Completion Date

2014-04-29

Brief Summary

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This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique. Increased flow is achieved trough obstructing blood flow with a cuff around the forearm for five minutes. FMD is measured before surgery and on the first morning after the operation.

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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CABG patients

Patients undergoing cardiac surgery for coronary artery disease with the use of heart-lung machine in St Olavs Hospital Trondheim University Hospital.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* admitted for coronary artery bypass surgery

Exclusion Criteria

* Ongoing treatment with nitrates or RAAS inhibiting drugs
* unstable coronary syndrome
* unstable circulation/shock
* renal failure
* hepatic failure
* autoimmune or inflammatory disease
* untreated hypertension.
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Olavs Hospital

OTHER

Sponsor Role collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Idar Kirkeby-Garstad, Md. PhD.

Role: STUDY_DIRECTOR

Department of Cardiothoracic Anesthesiolgy and Intensive Care, St. Olav's Hospital, Trondheim, Norway

Locations

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St. Olavs Hospital

Trondheim, Sør Trøndelag, Norway

Site Status

Countries

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Norway

References

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Dedichen HH, Hisdal J, Skogvoll E, Aadahl P, Kirkeby-Garstad I. Reduced reactive hyperemia may explain impaired flow-mediated dilation after on-pump cardiac surgery. Physiol Rep. 2017 May;5(10):e13274. doi: 10.14814/phy2.13274.

Reference Type RESULT
PMID: 28554963 (View on PubMed)

Other Identifiers

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REK nr 2013/1758

Identifier Type: -

Identifier Source: org_study_id