Survey of Current Management of Orthopaedic Complications in CMT Patients

NCT ID: NCT02001038

Last Updated: 2015-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

16 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-02-28

Study Completion Date

2014-11-30

Brief Summary

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Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. Foot deformities are frequent complications in CMT patients and orthopaedic surgery is often required. As yet there are no systematic studies on the management of orthopaedic complications in CMT patients and the current approach varies between centres. This study is a survey with the aim of understanding the current surgical approach to orthopaedic complications in CMT.

The target population includes orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropathies Consortium (INC).

Detailed Description

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The study protocol consists of a survey addressed to orthopaedic surgeons. The survey will be completed once and it includes two different scenarios of typical CMT patients (one adult and one child).

The orthopaedic surgeons will be asked which surgical procedures they would apply to each scenario:

* forefoot cavus,
* clawtoes and
* hindfoot varus

No medications or therapeutic agents are a component of this project.

Conditions

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Charcot-Marie-Tooth Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Groups

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Orthopaedic surgeons

Orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients at participants centres.

Survey

Intervention Type OTHER

Interventions

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Survey

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropatheis Consortium (INC)
* Willing to complete survey

Exclusion Criteria

* Does not read or speak English
* Inability to provide informed consent
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Hospital for Neurology and Neurosurgery, London

UNKNOWN

Sponsor Role collaborator

University of Iowa

OTHER

Sponsor Role collaborator

Children's Hospital of Philadelphia

OTHER

Sponsor Role collaborator

University of Pennsylvania

OTHER

Sponsor Role collaborator

University of Rochester

OTHER

Sponsor Role collaborator

Dubowitz Neuromuscular Centre

OTHER

Sponsor Role collaborator

Sydney Children's Hospitals Network

OTHER

Sponsor Role collaborator

Carlo Besta Neurological Institute

OTHER

Sponsor Role collaborator

Johns Hopkins University

OTHER

Sponsor Role collaborator

Vanderbilt University

OTHER

Sponsor Role collaborator

University of Washington

OTHER

Sponsor Role collaborator

National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

Stanford University

OTHER

Sponsor Role collaborator

Data Management and Coordinating Center (DMCC)

OTHER

Sponsor Role collaborator

Federal, State foundation and industry support: National Institute of Health (NIH), Muscular Dystrophy Association, Charcot Marie Tooth Association

UNKNOWN

Sponsor Role collaborator

University College London Hospitals

OTHER

Sponsor Role lead

Responsible Party

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Prof Mary Reilly

Professor of Clinical Neurology and Consultant Neurologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Prof Mary Reilly

Role: STUDY_CHAIR

National Hospital for Neurology and Neurosurgery

Locations

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National Hospital for Neurology and Neurosurgery

London, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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INC 6608

Identifier Type: -

Identifier Source: org_study_id