Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1250 participants
OBSERVATIONAL
2014-04-30
2024-04-30
Brief Summary
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Detailed Description
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Furthermore, an adequate structure should be established for the execution of studies with kidney stone patients, in order to then, if necessary, develop recommendations for useful monitoring or prophylactic measures, as well as new treatment options for kidney stone patients.
A control group of 250 stone-free volunteers matching patients cohort participants for sex and age started recruitment in October 2017 and will serve the purpose of comparison in future studies.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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SKSC Patients group
A group a 1000 subjects affected by kidney stone as described in the eligibility criteria will be recruited in the period 2014-2024 and the same exams will be repeated for each participants for a period of 3 years.
No intervention will be undertaken.
No interventions assigned to this group
SKSC Control group
A group of 250 stone-free participants will be recruited and analysed with the same protocol as the patients but in a single visit. This group will be used for comparison with the patients group in future studies.
No intervention will be undertaken.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Male or female
* Recurrent kidney stone episodes (more than 1) or an individual kidney stone episode with one or several of the following risk factors:
* The first manifestation at the a minimum age of 25
* Positive family history
* Non-calcium oxalate stones
* Gastrointestinal disorders (e.g. gastric bypass surgery, inflammatory bowel disease, malabsorption etc.)
* Osteoporosis
* Nephrocalcinosis
* Single kidneyness
* Currently pregnant
* Gout
* Metabolic syndrome ( Diabetes Mellitus type I and II )
* Residual calculi (at least 3 months after the therapy)
* Bilateral or multiple stones
* Chronic urinary tract infection
* Chronic renal failure (eGFR lower than 60 ml/min.)
* Kidney transplant
* Signed Declaration of informed consent
* Male or female
* Kidney-stone free (screening verification by low-dose CT-scan)
Exclusion Criteria
* Age below 18 years old
For SKSC Control Group
* Not signed Informed Consent form
* Age below 18 years old
* Pregnancy
* History of kidney stones
* Low-dose CT-scan positive for kidney stones during screening phase
18 Years
ALL
No
Sponsors
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The Swiss National Centre of Competence in Research Kidney Control of Homeostasis
OTHER
Responsible Party
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Locations
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Kantonsspital Aarau
Aarau, Canton of Aargau, Switzerland
HUG
Geneva, Canton of Geneva, Switzerland
USZ
Zurich, Canton of Zurich, Switzerland
Universitätsspital Basel
Basel, , Switzerland
Inselspital
Bern, , Switzerland
CHUV
Lausanne, , Switzerland
Countries
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Central Contacts
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Carsten Wagner, MD
Role: CONTACT
Facility Contacts
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Florian Buchkremer, MD
Role: primary
Thomas Ernandez, MD
Role: primary
Nilufar Mohebbi
Role: primary
Daniel Fuster, MD
Role: primary
Olivier Bonny, MD
Role: primary
References
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Roth B, Bonny O; Swiss Kidney Stone Cohort Investigators. The Swiss Kidney Stone Cohort: An Observational Study to Unravel the Cause of Renal Stone Formation. Eur Urol Focus. 2017 Feb;3(1):7-9. doi: 10.1016/j.euf.2017.03.003. Epub 2017 Mar 21.
Related Links
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Related Info
Other Identifiers
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KEK-2013-0330
Identifier Type: -
Identifier Source: org_study_id