Trial Outcomes & Findings for Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy (NCT NCT01986829)

NCT ID: NCT01986829

Last Updated: 2018-09-19

Results Overview

Defined as the percentage of patients with no progression (local recurrence of an ablated lesion or the appearance of a new lesion) after ablation.

Recruitment status

TERMINATED

Study phase

PHASE2

Target enrollment

9 participants

Primary outcome timeframe

3 months

Results posted on

2018-09-19

Participant Flow

The study opened to participant enrollment on 02/03/2014 and closed to participant enrollment on 06/19/2017.

Participant milestones

Participant milestones
Measure
Treatment (Ablation)
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Overall Study
STARTED
9
Overall Study
COMPLETED
8
Overall Study
NOT COMPLETED
1

Reasons for withdrawal

Reasons for withdrawal
Measure
Treatment (Ablation)
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Overall Study
Death
1

Baseline Characteristics

Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Treatment (Ablation)
n=9 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Age, Continuous
56 years
n=5 Participants
Sex: Female, Male
Female
4 Participants
n=5 Participants
Sex: Female, Male
Male
5 Participants
n=5 Participants
Ethnicity (NIH/OMB)
Hispanic or Latino
0 Participants
n=5 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
8 Participants
n=5 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
1 Participants
n=5 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=5 Participants
Race (NIH/OMB)
Asian
0 Participants
n=5 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=5 Participants
Race (NIH/OMB)
Black or African American
1 Participants
n=5 Participants
Race (NIH/OMB)
White
8 Participants
n=5 Participants
Race (NIH/OMB)
More than one race
0 Participants
n=5 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants
n=5 Participants
Region of Enrollment
United States
9 Participants
n=5 Participants

PRIMARY outcome

Timeframe: 3 months

Defined as the percentage of patients with no progression (local recurrence of an ablated lesion or the appearance of a new lesion) after ablation.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=8 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Progression-free Rate
6 Participants

SECONDARY outcome

Timeframe: Assessed up to 5 years

-Defined as time from diagnosis of metastatic disease to the time of death

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=9 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Overall Survival (OS)
23.6 months
Interval 5.1 to 44.5

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measures as they did not complete the surveys. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I have a lack of energy" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Lack of Energy
Not at all (score = 0)
0 Participants
2 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Lack of Energy
A little bit (score = 1)
2 Participants
1 Participants
2 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Lack of Energy
Somewhat (score = 2)
2 Participants
3 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Lack of Energy
Quite a bit (score = 3)
1 Participants
1 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Lack of Energy
Very much (score = 4)
2 Participants
0 Participants
0 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measures as they did not complete the surveys. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I have nausea" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Nausea
Not at all (score = 0)
5 Participants
6 Participants
2 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Nausea
A little bit (score = 1)
1 Participants
1 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Nausea
Somewhat (score = 2)
1 Participants
0 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Nausea
Quite a bit (score = 3)
0 Participants
0 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Nausea
Very much (score = 4)
0 Participants
0 Participants
0 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measures as they did not complete the surveys. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I worry that my condition will get worse" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Worry That the Condition Will Get Worse
Not at all (score = 0)
3 Participants
2 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Worry That the Condition Will Get Worse
A little bit (score = 1)
2 Participants
4 Participants
2 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Worry That the Condition Will Get Worse
Somewhat (score = 2)
1 Participants
0 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Worry That the Condition Will Get Worse
Quite a bit (score = 3)
0 Participants
1 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Worry That the Condition Will Get Worse
Very much (score = 4)
1 Participants
0 Participants
1 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measure as they did not complete the surveys. 1 participant did not complete this question on the survey at pre-treatment. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I am able to enjoy life" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=6 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Enjoy Life
Not at all (score = 0)
0 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Enjoy Life
A little bit (score = 1)
0 Participants
2 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Enjoy Life
Somewhat (score = 2)
3 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Enjoy Life
Quite a bit (score = 3)
1 Participants
0 Participants
2 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Enjoy Life
Very much (score = 4)
2 Participants
5 Participants
2 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measure as they did not complete the surveys. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I am sleeping well" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Sleep Well
Not at all (score = 0)
0 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Sleep Well
A little bit (score = 1)
2 Participants
2 Participants
2 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Sleep Well
Somewhat (score = 2)
2 Participants
3 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Sleep Well
Quite a bit (score = 3)
1 Participants
1 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Ability of the Participant to Sleep Well
Very much (score = 4)
2 Participants
1 Participants
0 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measure as they did not complete the surveys. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I am content with the quality of my life right now" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Contentment of the Participant's Qualify of Life
Not at all (score = 0)
0 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Contentment of the Participant's Qualify of Life
A little bit (score = 1)
1 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Contentment of the Participant's Qualify of Life
Somewhat (score = 2)
1 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Contentment of the Participant's Qualify of Life
Quite a bit (score = 3)
5 Participants
4 Participants
3 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Contentment of the Participant's Qualify of Life
Very much (score = 4)
0 Participants
3 Participants
1 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: -2 participants were not evaluable for the outcome measure as they did not complete the surveys. An additional participant did not complete the survey at progression. 2 additional participants did not progress and did not complete the surveys at disease progression.

* Measured with the FACT-G7 validated survey. Final assessment at time of disease progression. * The question participant was asked was "I have pain" * 7 questions about quality of life with answers that range from 0=not at all to 4 = very much * Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean QOL scores between any two times. All analyses will be two-sided at a significance level of 0.05. This statistical analysis was not able to be performed due to the sample size being too small.

Outcome measures

Outcome measures
Measure
Treatment (Ablation)
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Post-Treatment
n=7 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Disease Progression
n=4 Participants
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Pain
Not at all (score = 0)
2 Participants
2 Participants
1 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Pain
A little bit (score = 1)
5 Participants
1 Participants
3 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Pain
Somewhat (score = 2)
0 Participants
2 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Pain
Quite a bit (score = 3)
0 Participants
0 Participants
0 Participants
Change in Quality of Life (QOL) Following Ablation Procedure as Measured by the Participant's Pain
Very much (score = 4)
0 Participants
2 Participants
0 Participants

SECONDARY outcome

Timeframe: Pre-treatment (baseline), post-treatment (1-month post ablation), and disease progression (up to 5 years post-ablation)

Population: The data for this outcome measure was not collected as participant's pain was collected via the Fact G7 questionnaire.

Measured using the Brief Pain Inventory. Final assessment at time of disease progression. Generalized estimating equation (GEE) analysis will be used to take into account the correlation of repeated measures from the same subject. Contrast statements will be used to compare mean BPI scores between any two times. All analyses will be two-sided at a significance level of 0.05.

Outcome measures

Outcome data not reported

Adverse Events

Treatment (Ablation)

Serious events: 3 serious events
Other events: 1 other events
Deaths: 2 deaths

Serious adverse events

Serious adverse events
Measure
Treatment (Ablation)
n=9 participants at risk
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Blood and lymphatic system disorders
Intraoperative hemorrhage
11.1%
1/9 • Adverse event data was collected on the first day of ablation through 30 days following the completion of ablation.
Respiratory, thoracic and mediastinal disorders
Pneumothorax
33.3%
3/9 • Adverse event data was collected on the first day of ablation through 30 days following the completion of ablation.
Respiratory, thoracic and mediastinal disorders
Respiratory Failure
11.1%
1/9 • Adverse event data was collected on the first day of ablation through 30 days following the completion of ablation.
Respiratory, thoracic and mediastinal disorders
Pleural effusion
11.1%
1/9 • Adverse event data was collected on the first day of ablation through 30 days following the completion of ablation.

Other adverse events

Other adverse events
Measure
Treatment (Ablation)
n=9 participants at risk
* Patients undergo cryoablation, radiofrequency ablation, or microwave ablation of each lesion. * Patients complete pain survey (BPI-Short form) and quality of life questionnaires (FACT-G7)
Respiratory, thoracic and mediastinal disorders
Pneumothorax
11.1%
1/9 • Adverse event data was collected on the first day of ablation through 30 days following the completion of ablation.

Additional Information

Brian Van Tine, M.D.

Washington University School of Medicine

Phone: 314-362-5817

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place