Preload Dependence During Prone Position In ARDS Patients

NCT ID: NCT01965574

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2017-01-31

Brief Summary

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Preload dependence assessment is difficult during prone position, and to date, no hemodynamic parameters have been validated to rationalize fluid loading in that position. This study aims to validate several hemodynamic parameters, using continuous cardiac output by pulse contour analysis and transpulmonary thermodilution.

Detailed Description

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Conditions

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ARDS PATIENTS WITH HEMODYNAMIC INSTABILITY

Keywords

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ARDS - FLUID LOADING - PRELOAD DEPENDENCE

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Single arm

Group Type EXPERIMENTAL

Trendelenburg position

Intervention Type PROCEDURE

Interventions

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Trendelenburg position

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* ARDS patient
* mechanically ventilated in prone position
* sedated and paralyzed
* with continuous cardiac output monitoring by transpulmonary thermodilution and pulse contour analysis
* fluid loading as indicated by attending physician

Exclusion Criteria

* Age below 18
* no affiliation to social security
* Vena cava obstruction
* previous inclusion in protocol
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jean Christophe RICHARD

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon

Locations

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Hôpital de la Croix Rousse

Lyon, , France

Site Status

Countries

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France

References

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Yonis H, Bitker L, Aublanc M, Perinel Ragey S, Riad Z, Lissonde F, Louf-Durier A, Debord S, Gobert F, Tapponnier R, Guerin C, Richard JC. Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation. Crit Care. 2017 Dec 5;21(1):295. doi: 10.1186/s13054-017-1881-0.

Reference Type RESULT
PMID: 29208025 (View on PubMed)

Other Identifiers

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2012.783

Identifier Type: -

Identifier Source: org_study_id