Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2014-01-31
2016-11-14
Brief Summary
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Magnetic Resonance Imaging-guided High Intensity Focused Ultrasound (MR-HIFU) uses ultrasound to palliate pain caused by bone metastases. The main palliative mechanism of the method is due to local bone denervation, caused by the heat denaturation of the periosteum layer in the treated area. The importance of this therapy is that it offers a non-invasive, focal therapy, avoiding side-effects to surrounding normal tissue that occur with radiation therapy or the need for needle insertion as with radio-frequency(RF)ablation.
The study hypothesis is that MR-HIFU will be effective in treating the pain associated with bone metastases
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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MR-HIFU of painful bone metastases
Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
Interventions
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Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
Eligibility Criteria
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Inclusion Criteria
* diagnosis of dominant painful bone metastasis
* target lesion less than 8cm
Exclusion Criteria
* Inability to tolerate stationary position during treatment
* pregnancy
* MRI incompatible metal implants
18 Years
ALL
No
Sponsors
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Philips Medical Systems
INDUSTRY
Institute of Cancer Research, United Kingdom
OTHER
Responsible Party
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NdeSouza
Professor of Translational Imaging
Principal Investigators
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Nandita deSouza, Professor
Role: PRINCIPAL_INVESTIGATOR
ICR
Locations
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The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom
Countries
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Other Identifiers
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12/LO/0424 CCR3772
Identifier Type: -
Identifier Source: org_study_id
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