Post-marketing Study to Evaluate the Effect of Mirabegron on the Plasma Concentration of Tolterodine

NCT ID: NCT01964183

Last Updated: 2013-10-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-06-30
• Study Completion Date: 2013-08-31

Brief Summary

To assess the effect of multiple doses of mirabegron to postmenopausal adult female subjects on the pharmacokinetics (PK) of tolterodine and its metabolites.

In addition, the safety of these products will be assessed.

Conditions

Pharmacokinetics of Mirabegron and Tolterodine; Healthy

Keywords

Open-label design; Pharmacokinetics; Drug-Drug Interaction; Mirabegron

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Blinding Strategy: NONE

Study Groups

treatment group

Group Type: EXPERIMENTAL

tolterodine

Intervention Type: DRUG

Oral

mirabegron

Intervention Type: DRUG

Oral

Interventions

tolterodine

Oral

Intervention Type: DRUG

mirabegron

Oral

Intervention Type: DRUG

Other Intervention Names

Detrusitol® Capsules; YM178; Betanis® tablets

Eligibility Criteria

Inclusion Criteria

• Subjects of two years after menopause
• Body weight (at screening) ≥ 40.0 kg and < 70.0 kg
• Body mass index (BMI) (at screening) ≥ 17.6 kg/m2 and < 26.4 kg/m2
• Healthy, as judged by the investigator/sub-investigator based on medical history and the results of physical examination (subjective symptoms and objective findings) and all tests obtained at screening and during the period from hospital admission (at single dosing phase) to immediately before study medication.

Exclusion Criteria

• Received or scheduled to receive any investigational drugs in other clinical trials, post-marketing studies, or clinical studies within 120 days before the screening or during the period from the screening to hospitalization (Day -2).
• Donated or scheduled to donate 400 mL of whole blood within 90 days before the screening or during the period from the screening to hospitalization (Day -2), 200 mL of whole blood within 30 days before the screening or during the period from the screening to hospitalization (Day -2), or blood components within 14 days before the screening or during the period from the screening to hospitalization (Day -2).
• Any deviation of the laboratory tests at screening or hospitalization (Day -2).
• A deviation from the normal range of blood pressure, pulse rae, or body temperature at screening or hospitalization (Day -2) Supine blood pressure: Systolic blood pressure: ≥90 mmHg, ≤140 mmHg, Diastolic blood pressure: ≥40 mmHg, ≤90 mmHg Supine pulse rate; ≥40 bpm, ≤99 bpm Axillary body temperature; ≥35.0°C, ≤37.0°C
• History of drug allergies
• Upper gastrointestinal disease (e.g., nausea, vomiting, and stomachache) within 7 days before hospitalization (Day -2)
• Concurrent or previous hepatic disease (e.g., viral hepatitis, drug-induced liver injury, and hepatic impairment)
• Concurrent or previous heart disease (e.g., congestive heart failure, angina pectoris, and arrhythmia requiring treatment)
• Concurrent or previous GI disease (e.g., ileus paralytic, gastric atony, intestinal atony, colitis ulcerative, peptic ulcer and gastroesophageal reflux esophagitis; except for a history of appendicitis).
• Concurrent or previous renal disease (e.g., acute renal failure, glomerulonephritis, and interstitial nephritis)
• Concurrent or previous endocrine disease (e.g., hyperthyroidism and blood growth hormone abnormal)
• Concurrent or previous cerebrovascular disorder (e.g., cerebral infarction)
• Previous use of mirabegron or tolterodine
• Excessive smoking or drinking habit

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Astellas Pharma Inc

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Medical Director

Role: STUDY_CHAIR

Astellas Pharma Inc

Locations

Kanto, , Japan

Countries

Japan

Other Identifiers

178-CL-111

Identifier Type: -

Identifier Source: org_study_id