A Study of Vantictumab (OMP-18R5) in Combination With Docetaxel in Patients With Previously Treated NSCLC

NCT ID: NCT01957007

Last Updated: 2020-09-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-09-30
• Study Completion Date: 2017-06-30

Brief Summary

This is an open-label Phase 1b dose-escalation study to assess the safety, tolerability, and PK of vantictumab when combined with docetaxel.

Detailed Description

Once the maximum tolerated dose (MTD) or maximum administered dose (MAD) has been determined, up to 10 patients may be enrolled in the cohort-expansion phase to better characterize the safety, tolerability and PK of vantictumab combined with docetaxel. Up to approximately 34 patients may be enrolled into the study.

Conditions

Solid Tumors

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Docetaxel

Drug: Docetaxel - administered intravenously

Group Type: EXPERIMENTAL

Docetaxel

Intervention Type: DRUG

Docetaxel will be administered IV.

vantictumab

Intervention Type: DRUG

Vantictumab will be administered intravenously

vantictumab

Drug: vantictumab - administered intravenously

Group Type: EXPERIMENTAL

Docetaxel

Intervention Type: DRUG

Docetaxel will be administered IV.

vantictumab

Intervention Type: DRUG

Vantictumab will be administered intravenously

Interventions

Docetaxel

Docetaxel will be administered IV.

Intervention Type: DRUG

vantictumab

Vantictumab will be administered intravenously

Intervention Type: DRUG

Other Intervention Names

(OMP-18R5)

Eligibility Criteria

Inclusion Criteria

• Signed Informed Consent Form
• Age ≥18 years
• Histologically documented recurrent or advanced (Stage IV) NSCLC
• Eastern CooperativeOncology Group (ECOG) performance status of 0 or 1
• All acute treatmentrelated toxicity from prior therapy must have resolved to Grade ≤ 1 prior to study entry
• Adequate hematologic and end-organ function
• Evaluable or measurable disease per RECIST v1.1
• For women of childbearing potential and men with partners of childbearing potential, agreement to use two effective forms of contraception

Exclusion Criteria

• Prior treatment with docetaxel for recurrent or advanced NSCLC
• More than two regimens of systemic cytotoxic chemotherapy for recurrent or advanced NSCLC
• Treatment with any anti-cancer therapy within 3 weeks prior to initiation of study treatment
• Known hypersensitivity to any component of study treatments
• Grade ≥ 2 sensory neuropathy
• Uncontrolled seizure disorder or active neurologic disease
• Untreated brain metastases
• Leptomeningeal disease as a manifestation of cancer
• Active infection requiring antibiotics
• Bisphosphonate therapy for symptomatic hypercalcemia
• Known history of clinically significant liver disease, including active viral hepatitis and cirrhosis
• Significant intercurrent illness including, but not limited to, unstable angina pectoris, and cardiac arrhythmia, or psychiatric illness/social situation that would limit compliance with study requirements
• Pregnancy, lactation, or breastfeeding
• Known HIV infection
• Evidence of bleeding diathesis or significant coagulopathy (in the absence of therapeutic anticoagulation)
• Concurrent use of therapeutic warfarin
• New York Heart Association Classification III or IV (see Appendix E)
• Known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease
• Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to the first dose of study treatment or anticipation of need for major surgical procedure during the course of the study
• Osteoporosis based on a T-score of <-2.5 at the left or right total hip, left or right femoral neck or lumbar spine (L1-L4) as determined by DEXA scan
• Bone metastases and one of the following:

• Prior history of a pathologic fracture
• Lytic lesion requiring an impending orthopedic intervention
• Lack of treatment with a bisphosphonate or denosumab
• Treatment with a thiazolidinedione PPAR gamma inhibitor; e.g. Actos® (pioglitazone), and Avandia® (rosiglitzone)
• Active treatment with an oral or IV glucocortocoid for ≥4 weeks at a daily dose equivalent to or greater than 7.5 mg of oral prednisone
• Fasting β-CTX of >1000 pg/mL
• Metabolic bone disease, such as hyperparathyroidism, Paget's disease or osteomalacia

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

OncoMed Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University of Colorado

Aurora, Colorado, United States

Roswell Park Cancer Center, Elm & Carlton Streets

Buffalo, New York, United States

Case Western Reserve University

Cleveland, Ohio, United States

Countries

United States

Other Identifiers

18R5-004

Identifier Type: -

Identifier Source: org_study_id