Enzalutamide With or Without Abiraterone and Prednisone in Treating Patients With Castration-Resistant Metastatic Prostate Cancer

NCT ID: NCT01949337

Last Updated: 2023-09-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

1311 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-22

Study Completion Date

2024-08-31

Brief Summary

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This randomized phase III trial studies enzalutamide to see how well it works compared to enzalutamide, abiraterone, and prednisone in treating patients with castration-resistant metastatic prostate cancer. Androgens can cause the growth of prostate cancer cells. Drugs, such as enzalutamide, abiraterone acetate, and prednisone, may lessen the amount of androgens made by the body.

Detailed Description

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Patients are randomized to one of two treatment groups: enzalutamide or enzalutamide, abiraterone and prednisone. Treatment will continue until disease progression or unacceptable toxicity. Patients are followed for clinical outcomes for a maximum of 5 years post study treatment. The primary and secondary objectives are described below.

1. Primary Objective:

To compare the overall survival of patients with progressive metastatic castration-resistant prostate cancer (CRPC) treated with either enzalutamide only or enzalutamide with abiraterone and prednisone
2. Secondary Objectives:

* To assess the grade 3 or higher toxicity profile and compare safety by treatment arm.
* To assess and compare post-treatment prostate-specific antigen (PSA) declines by treatment arm.
* To compare radiographic progression free survival defined by Prostate Cancer Working Group 2 (PCWG2), and objective response rate, by treatment arm.
* To test for radiographic progression free survival (rPFS) treatment interaction in predicting overall survival.
* To assess pre- and post-treatment measures of tumor burden and bone activity using sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) and technetium (Tc) methylene diphosphonate (MDP) bone scintigraphy and correlate these measures with overall survival.
* To develop and validate prognostic and predictive models of overall survival that include baseline clinical and molecular markers.

Conditions

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Adenocarcinoma of the Prostate Hormone-resistant Prostate Cancer Recurrent Prostate Cancer Stage IV Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm A: (enzalutamide)

Patients receive enzalutamide 160 mg PO QD. Treatment will continue until confirmed disease progression or unacceptable toxicity.

Group Type EXPERIMENTAL

enzalutamide

Intervention Type DRUG

Enzalutamide 160 mg daily, orally

Arm B: (enzalutamide, abiraterone, prednisone)

Patients receive enzalutamide 160 mg PO QD, abiraterone 1000 mg PO QD, and prednisone 5 mg PO BID. Treatment will continue until confirmed disease progression or unacceptable toxicity.

Group Type EXPERIMENTAL

enzalutamide

Intervention Type DRUG

Enzalutamide 160 mg daily, orally

abiraterone

Intervention Type DRUG

abiraterone 1000 mg daily, orally

prednisone

Intervention Type DRUG

prednisone 5 mg twice daily, orally

Interventions

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enzalutamide

Enzalutamide 160 mg daily, orally

Intervention Type DRUG

abiraterone

abiraterone 1000 mg daily, orally

Intervention Type DRUG

prednisone

prednisone 5 mg twice daily, orally

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Eligibility Criteria:

1. Documentation of Disease - Progressive castration-resistant metastatic prostate cancer with histologically or cytologically confirmed adenocarcinoma of the prostate without neuroendocrine differentiation or small cell features
2. Patients must have measurable or non-measurable disease:

1. Measurable Disease - For visceral or extra nodal lesions to be considered measurable, they must be ≥ 10 mm in one dimension, using spiral CT. For lymph nodes to be considered measurable (ie, target or evaluable lesions), they must be ≥ 20 mm in at least one dimension, using spiral CT.
2. Non-Measurable Disease - All other lesions, including small lesions (longest diameter \< 20 mm with conventional techniques or \< 10 mm with spiral CT scan) and truly non-measurable lesions. Lesions that are considered non-measurable include bone lesions (only).
3. Patients with node only disease (ie, no presence of visceral, extra nodal lesions or bone lesions) must have node(s) that measure ≥ 15 mm in short axis.
3. Progressive Disease - Patients must have progressive disease at study entry defined as one or more of the following three criteria that occurred while the patient was on androgen deprivation therapy. For patients enrolling on the basis of soft tissue or bone progression, the baseline scan must show progression relative to a comparison scan. If the comparison scan is not available, the baseline scan report must reference the previous scan to document progression.

1. PSA progression defined by a minimum of two rising PSA levels with an interval of ≥ 1 week between each determination. Patients who received an anti-androgen must have progression documented by a minimum of two rising PSA levels with an interval of ≥ 1 week between each determination such that at least the second of these rises is ≥ 4 weeks since last flutamide, bicalutamide or nilutamide.

The PSA value at the screening should be ≥ 2 µg/L (2 ng/mL) .
2. Soft tissue disease progression defined by the protocol
3. Bone disease progression defined by the Prostate Cancer Working Group 2 (PCWG2) with two or more new lesions on bone scan
4. Prior Treatment

1. No treatment with prior taxane-based chemotherapy for metastatic disease

* Patients who received prior taxane-based chemotherapy as neoadjuvant or adjuvant therapy for local disease, or who received taxane-based therapy in the PSA clinical (non-metastatic) state is allowable provided that the total duration of exposure was six cycles or less and chemotherapy was completed more than 6 months prior to registration
* Taxane-based chemotherapy that was aborted due to allergic reactions or intolerance to chemotherapy and therefore received one cycle of prior therapy is allowable
2. No prior enzalutamide, abiraterone or other novel antiandrogen or androgen synthesis inhibitor
3. No treatment with any of the following for prostate cancer within 4 weeks prior to enrollment:

* Hormonal therapy (e.g., androgen receptor \[AR\] antagonists, 5 alpha reductase inhibitors, estrogens) Note: Treatment with bicalutamide and nilutamide within 4 weeks prior to enrollment is not allowed. Treatment with flutamide within 4 weeks prior to enrollment is not allowed. Treatment with all other gonadotropin- releasing hormone (GnRH) analogues or antagonists is allowed.
* Chemotherapy
* Biologic therapy
* Investigational therapy
* Immunotherapy
4. No use of herbal products that may decrease PSA levels within 4 weeks prior to enrollment
5. No use of systemic steroids greater than the equivalent of 10 mg of prednisone/prednisolone per day within 4 weeks prior to enrollment
6. No prior use of ketoconazole for greater than 7 days
7. No prior radiation therapy or radionuclide therapy for the treatment of metastasis within four weeks prior to enrollment
8. Patients receiving bisphosphonate therapy or denosumab must have been on a stable dose for at least 4 weeks prior to enrollment
9. Patients must maintain ongoing androgen deprivation therapy with a GnRH analogue, antagonist, or bilateral orchiectomy (i.e., surgical or medical castration)
5. Patient History

1. No known or suspected brain metastases (NOTE: patients with treated epidural disease are allowed)
2. No planned palliative procedures for alleviation of bone pain such as radiation therapy or surgery
3. No structurally unstable bone lesions suggesting impending fracture
4. No history of seizure or any condition that may increase the patient's seizure risk (e.g., prior cortical stroke, significant brain trauma). No history of transient ischemic attack (TIA) within 12 months of enrollment
5. No clinically significant cardiovascular disease including:

* Myocardial infarction (MI) within 6 months
* Uncontrolled angina within 3 months
* Congestive heart failure (CHF) with New York Heart Association (NYHA) class 3 or 4, or patients with NYHA class 3 or 4 in the past, unless a screening echocardiogram (echo) or multigated acquisition scan (MUGA) performed within three months demonstrates an ejection fraction (EF) \> 45%
* History of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes)
* History of Mobitz II second degree or third degree heart block without a permanent pacemaker in place
* Hypotension (systolic blood pressure \[BP\] \< 86 mmHg) or bradycardia (\< 50 bpm) at screening
* Uncontrolled hypertension (systolic BP \> 170 mmHg or diastolic BP \> 105 mmHg at screening)
6. No gastrointestinal (GI) disorder that negatively affects absorption
7. No major surgery within 4 weeks prior to enrollment
6. Age and performance status

1. Age ≥ 18 years of age
2. Eastern Cooperative Oncology Group (ECOG) performance status 0-1
3. Asymptomatic or mildly symptomatic from prostate cancer
7. Required Initial Laboratory Values

1. Granulocytes ≥ 1,500/µL
2. Platelet count ≥ 100,000/µL
3. Hemoglobin ≥ 9 g/dL
4. Creatinine ≤ 2 x upper limits of normal (ULN)
5. Bilirubin ≤ 1.5 x ULN
6. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≤ 2 x ULN
7. Albumin ≥ 3 g/dl
8. Total testosterone ≤ 50 ng/dL (1.7 nmol/L)
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Astellas Pharma US, Inc.

INDUSTRY

Sponsor Role collaborator

Medivation, Inc.

INDUSTRY

Sponsor Role collaborator

Biologics, Inc.

INDUSTRY

Sponsor Role collaborator

Alliance for Clinical Trials in Oncology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Morris, M.D.

Role: STUDY_CHAIR

Memorial Sloan Kettering Cancer Center

Locations

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University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, United States

Site Status

Southern Cancer Center PC-Providence

Mobile, Alabama, United States

Site Status

Katmai Oncology Group

Anchorage, Alaska, United States

Site Status

Providence Alaska Medical Center

Anchorage, Alaska, United States

Site Status

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Site Status

University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, United States

Site Status

University of Arizona Cancer Center-North Campus

Tucson, Arizona, United States

Site Status

The University of Arizona Medical Center-University Campus

Tucson, Arizona, United States

Site Status

Fowler Family Center for Cancer Care

Jonesboro, Arkansas, United States

Site Status

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

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Veteran's Administration Medical Center

Little Rock, Arkansas, United States

Site Status

Kaiser Permanente-Anaheim

Anaheim, California, United States

Site Status

Kaiser Permanente-Deer Valley Medical Center

Antioch, California, United States

Site Status

Kaiser Permanente-Baldwin Park

Baldwin Park, California, United States

Site Status

Kaiser Permanente-Bellflower

Bellflower, California, United States

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Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States

Site Status

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, United States

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City of Hope Comprehensive Cancer Center

Duarte, California, United States

Site Status

Kaiser Permanente Hospital

Fontana, California, United States

Site Status

Kaiser Permanente-Fremont

Fremont, California, United States

Site Status

University Oncology Associates

Fresno, California, United States

Site Status

California Cancer Center - North Fresno

Fresno, California, United States

Site Status

Kaiser Permanente

Fresno, California, United States

Site Status

Marin Cancer Care Inc

Greenbrae, California, United States

Site Status

Kaiser Permanente - Harbor City

Harbor City, California, United States

Site Status

Kaiser Permanente-Irvine

Irvine, California, United States

Site Status

UC San Diego Moores Cancer Center

La Jolla, California, United States

Site Status

Loma Linda University Medical Center

Loma Linda, California, United States

Site Status

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States

Site Status

Los Angeles County-USC Medical Center

Los Angeles, California, United States

Site Status

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

Site Status

Kaiser Permanente-Cadillac

Los Angeles, California, United States

Site Status

Fremont - Rideout Cancer Center

Marysville, California, United States

Site Status

Memorial Medical Center

Modesto, California, United States

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Kaiser Permanente-Modesto

Modesto, California, United States

Site Status

USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, United States

Site Status

Kaiser Permanente-Oakland

Oakland, California, United States

Site Status

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, United States

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Palo Alto Medical Foundation Health Care

Palo Alto, California, United States

Site Status

Kaiser Permanente - Panorama City

Panorama City, California, United States

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Feather River Cancer Center

Paradise, California, United States

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Kaiser Permanente-Redwood City

Redwood City, California, United States

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Kaiser Permanente-Richmond

Richmond, California, United States

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Kaiser Permanente-Riverside

Riverside, California, United States

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Kaiser Permanente-Roseville

Roseville, California, United States

Site Status

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

Site Status

Kaiser Permanente-South Sacramento

Sacramento, California, United States

Site Status

Kaiser Permanente - Sacramento

Sacramento, California, United States

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Kaiser Permanente-San Diego Zion

San Diego, California, United States

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Sharp Memorial Hospital

San Diego, California, United States

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Naval Medical Center -San Diego

San Diego, California, United States

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Veterans Administration-San Diego Medical Center

San Diego, California, United States

Site Status

Kaiser Permanente-San Francisco

San Francisco, California, United States

Site Status

UCSF Medical Center-Mount Zion

San Francisco, California, United States

Site Status

Veterans Affairs Medical Center - San Francisco

San Francisco, California, United States

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UCSF Medical Center-Mission Bay

San Francisco, California, United States

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Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, United States

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Kaiser Permanente San Leandro

San Leandro, California, United States

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Kaiser Permanente-San Marcos

San Marcos, California, United States

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Kaiser Permanente-San Rafael

San Rafael, California, United States

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Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, United States

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Palo Alto Medical Foundation-Santa Cruz

Santa Cruz, California, United States

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Kaiser Permanente-Santa Rosa

Santa Rosa, California, United States

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Kaiser Permanente-South San Francisco

South San Francisco, California, United States

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Saint Helena Hospital

St. Helena, California, United States

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Saint Joseph's Medical Center

Stockton, California, United States

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Kaiser Permanente-Stockton

Stockton, California, United States

Site Status

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, United States

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Kaiser Permanente Medical Center-Vacaville

Vacaville, California, United States

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Kaiser Permanente-Vallejo

Vallejo, California, United States

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Kaiser Permanente-Walnut Creek

Walnut Creek, California, United States

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Kaiser Permanente

Woodland Hills, California, United States

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Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, United States

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Memorial Hospital Colorado Springs

Colorado Springs, Colorado, United States

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Kaiser Permanente-Franklin

Denver, Colorado, United States

Site Status

Southwest Oncology PC

Durango, Colorado, United States

Site Status

The Shaw Regional Cancer Center

Edwards, Colorado, United States

Site Status

Poudre Valley Hospital

Fort Collins, Colorado, United States

Site Status

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, United States

Site Status

Greenwich Hospital

Greenwich, Connecticut, United States

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Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, United States

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Middlesex Hospital

Middletown, Connecticut, United States

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Norwalk Hospital

Norwalk, Connecticut, United States

Site Status

Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, United States

Site Status

Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut, United States

Site Status

Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, United States

Site Status

Medical Oncology Hematology Consultants PA

Newark, Delaware, United States

Site Status

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, United States

Site Status

Sibley Memorial Hospital

Washington D.C., District of Columbia, United States

Site Status

Veterans Affairs Medical Center -Washington DC

Washington D.C., District of Columbia, United States

Site Status

Baptist MD Anderson Cancer Center

Jacksonville, Florida, United States

Site Status

Lakeland Regional Cancer Center

Lakeland, Florida, United States

Site Status

Mount Sinai Medical Center

Miami Beach, Florida, United States

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Florida Hospital Orlando

Orlando, Florida, United States

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UF Cancer Center at Orlando Health

Orlando, Florida, United States

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Sacred Heart Hospital

Pensacola, Florida, United States

Site Status

Northside Hospital

Atlanta, Georgia, United States

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John B Amos Cancer Center

Columbus, Georgia, United States

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Atlanta VA Medical Center

Decatur, Georgia, United States

Site Status

Medical Center of Central Georgia

Macon, Georgia, United States

Site Status

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States

Site Status

South Georgia Medical Center/Pearlman Cancer Center

Valdosta, Georgia, United States

Site Status

Hawaii Cancer Care Inc-POB II

Honolulu, Hawaii, United States

Site Status

Hawaii Oncology Inc-POB I

Honolulu, Hawaii, United States

Site Status

Island Urology

Honolulu, Hawaii, United States

Site Status

Queen's Medical Center

Honolulu, Hawaii, United States

Site Status

Straub Clinic and Hospital

Honolulu, Hawaii, United States

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University of Hawaii Cancer Center

Honolulu, Hawaii, United States

Site Status

Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, United States

Site Status

Hawaii Oncology Inc-Kuakini

Honolulu, Hawaii, United States

Site Status

Kuakini Medical Center

Honolulu, Hawaii, United States

Site Status

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, United States

Site Status

Tripler Army Medical Center

Honolulu, Hawaii, United States

Site Status

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, United States

Site Status

Hawaii Oncology Inc-Pali Momi

‘Aiea, Hawaii, United States

Site Status

Pali Momi Medical Center

‘Aiea, Hawaii, United States

Site Status

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States

Site Status

Kootenai Cancer Center

Post Falls, Idaho, United States

Site Status

Rush - Copley Medical Center

Aurora, Illinois, United States

Site Status

Illinois CancerCare-Bloomington

Bloomington, Illinois, United States

Site Status

Mount Sinai Hospital Medical Center

Chicago, Illinois, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

Rush University Medical Center

Chicago, Illinois, United States

Site Status

Weiss Memorial Hospital

Chicago, Illinois, United States

Site Status

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States

Site Status

Cancer Care Center of Decatur

Decatur, Illinois, United States

Site Status

Decatur Memorial Hospital

Decatur, Illinois, United States

Site Status

Crossroads Cancer Center

Effingham, Illinois, United States

Site Status

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, United States

Site Status

Illinois CancerCare-Galesburg

Galesburg, Illinois, United States

Site Status

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, United States

Site Status

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, United States

Site Status

Ingalls Memorial Hospital

Harvey, Illinois, United States

Site Status

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, United States

Site Status

Hines Veterans Administration Hospital

Hines, Illinois, United States

Site Status

Loyola University Medical Center

Maywood, Illinois, United States

Site Status

Illinois CancerCare-Peoria

Peoria, Illinois, United States

Site Status

Quincy Medical Group-Clinic

Quincy, Illinois, United States

Site Status

West Suburban Medical Center

River Forest, Illinois, United States

Site Status

OSF Saint Anthony Medical Center

Rockford, Illinois, United States

Site Status

Central Illinois Hematology Oncology Center

Springfield, Illinois, United States

Site Status

Southern Illinois University School of Medicine

Springfield, Illinois, United States

Site Status

Memorial Medical Center

Springfield, Illinois, United States

Site Status

Carle Cancer Center

Urbana, Illinois, United States

Site Status

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States

Site Status

Fort Wayne Medical Oncology and Hematology Inc - Jefferson Boulevard

Fort Wayne, Indiana, United States

Site Status

Fort Wayne Medical Oncology and Hematology Inc-Parkview

Fort Wayne, Indiana, United States

Site Status

Michiana Hematology Oncology PC-Mishawaka

Mishawaka, Indiana, United States

Site Status

The Community Hospital

Munster, Indiana, United States

Site Status

Memorial Hospital of South Bend

South Bend, Indiana, United States

Site Status

Michiana Hematology Oncology PC-Westville

Westville, Indiana, United States

Site Status

McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa, United States

Site Status

Hematology Oncology Associates-Quad Cities

Bettendorf, Iowa, United States

Site Status

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, United States

Site Status

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, United States

Site Status

Mercy Cancer Center-West Lakes

Clive, Iowa, United States

Site Status

Genesis Medical Center - East Campus

Davenport, Iowa, United States

Site Status

Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, United States

Site Status

Mercy Medical Center - Des Moines

Des Moines, Iowa, United States

Site Status

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, United States

Site Status

Iowa City VA Healthcare System

Iowa City, Iowa, United States

Site Status

Mercy Medical Center - North Iowa

Mason City, Iowa, United States

Site Status

Siouxland Regional Cancer Center

Sioux City, Iowa, United States

Site Status

Mercy Medical Center-West Lakes

West Des Moines, Iowa, United States

Site Status

Cancer Center of Kansas - Chanute

Chanute, Kansas, United States

Site Status

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, United States

Site Status

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, United States

Site Status

Newman Regional Health

Emporia, Kansas, United States

Site Status

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, United States

Site Status

Saint Catherine Hospital

Garden City, Kansas, United States

Site Status

Saint Rose Ambulatory and Surgery Center

Great Bend, Kansas, United States

Site Status

Hays Medical Center

Hays, Kansas, United States

Site Status

Cancer Center of Kansas-Independence

Independence, Kansas, United States

Site Status

University of Kansas Cancer Center-West

Kansas City, Kansas, United States

Site Status

University of Kansas Cancer Center

Kansas City, Kansas, United States

Site Status

Cancer Center of Kansas-Kingman

Kingman, Kansas, United States

Site Status

Cancer Center of Kansas-Liberal

Liberal, Kansas, United States

Site Status

Cancer Center of Kansas - Newton

Newton, Kansas, United States

Site Status

Olathe Medical Center

Olathe, Kansas, United States

Site Status

Menorah Medical Center

Overland Park, Kansas, United States

Site Status

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, United States

Site Status

Saint Luke's South Hospital

Overland Park, Kansas, United States

Site Status

Cancer Center of Kansas - Parsons

Parsons, Kansas, United States

Site Status

Via Christi Hospital-Pittsburg

Pittsburg, Kansas, United States

Site Status

Cancer Center of Kansas - Pratt

Pratt, Kansas, United States

Site Status

Cancer Center of Kansas - Salina

Salina, Kansas, United States

Site Status

Salina Regional Health Center

Salina, Kansas, United States

Site Status

Saint Francis Hospital and Medical Center - Topeka

Topeka, Kansas, United States

Site Status

Cancer Center of Kansas - Wellington

Wellington, Kansas, United States

Site Status

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, United States

Site Status

Cancer Center of Kansas - Wichita

Wichita, Kansas, United States

Site Status

Cancer Center of Kansas - Winfield

Winfield, Kansas, United States

Site Status

Saint Joseph Hospital East

Lexington, Kentucky, United States

Site Status

Christus Saint Frances Cabrini Hospital

Alexandria, Louisiana, United States

Site Status

Hematology/Oncology Clinic LLP

Baton Rouge, Louisiana, United States

Site Status

Ochsner Health Center-Summa

Baton Rouge, Louisiana, United States

Site Status

Ochsner Medical Center Kenner

Kenner, Louisiana, United States

Site Status

East Jefferson General Hospital

Metairie, Louisiana, United States

Site Status

Tulane University Health Sciences Center

New Orleans, Louisiana, United States

Site Status

Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States

Site Status

Harold Alfond Center for Cancer Care

Augusta, Maine, United States

Site Status

Eastern Maine Medical Center

Bangor, Maine, United States

Site Status

Lafayette Family Cancer Center-EMMC

Brewer, Maine, United States

Site Status

Penobscot Bay Medical Center

Rockport, Maine, United States

Site Status

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, United States

Site Status

Sinai Hospital of Baltimore

Baltimore, Maryland, United States

Site Status

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, United States

Site Status

Frederick Memorial Hospital

Frederick, Maryland, United States

Site Status

Montgomery General Hospital-Olney

Olney, Maryland, United States

Site Status

William E Kahlert Regional Cancer Center/Sinai Hospital

Westminster, Maryland, United States

Site Status

Tufts Medical Center

Boston, Massachusetts, United States

Site Status

Simonds-Sinon Regional Cancer Center

Fitchburg, Massachusetts, United States

Site Status

Newton-Wellesley Hospital

Newton, Massachusetts, United States

Site Status

Baystate Medical Center

Springfield, Massachusetts, United States

Site Status

University of Massachusetts Medical School

Worcester, Massachusetts, United States

Site Status

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States

Site Status

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

Site Status

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, United States

Site Status

Henry Ford Hospital

Detroit, Michigan, United States

Site Status

Green Bay Oncology - Escanaba

Escanaba, Michigan, United States

Site Status

Mercy Health Saint Mary's

Grand Rapids, Michigan, United States

Site Status

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, United States

Site Status

Green Bay Oncology - Iron Mountain

Iron Mountain, Michigan, United States

Site Status

West Michigan Cancer Center

Kalamazoo, Michigan, United States

Site Status

Sparrow Hospital

Lansing, Michigan, United States

Site Status

Saint Mary Mercy Hospital

Livonia, Michigan, United States

Site Status

Spectrum Health Reed City Hospital

Reed City, Michigan, United States

Site Status

Saint Mary's of Michigan

Saginaw, Michigan, United States

Site Status

Munson Medical Center

Traverse City, Michigan, United States

Site Status

Sanford Clinic North-Bemidgi

Bemidji, Minnesota, United States

Site Status

Fairview Ridges Hospital

Burnsville, Minnesota, United States

Site Status

Mercy Hospital

Coon Rapids, Minnesota, United States

Site Status

Essentia Health Cancer Center

Duluth, Minnesota, United States

Site Status

Saint Luke's Hospital of Duluth

Duluth, Minnesota, United States

Site Status

Fairview-Southdale Hospital

Edina, Minnesota, United States

Site Status

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota, United States

Site Status

Unity Hospital

Fridley, Minnesota, United States

Site Status

Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, United States

Site Status

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, United States

Site Status

Saint John's Hospital - Healtheast

Maplewood, Minnesota, United States

Site Status

Abbott-Northwestern Hospital

Minneapolis, Minnesota, United States

Site Status

Hennepin County Medical Center

Minneapolis, Minnesota, United States

Site Status

Minneapolis Veterans Medical Center

Minneapolis, Minnesota, United States

Site Status

Health Partners Inc

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, United States

Site Status

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, United States

Site Status

Regions Hospital

Saint Paul, Minnesota, United States

Site Status

Saint Francis Regional Medical Center

Shakopee, Minnesota, United States

Site Status

Lakeview Hospital

Stillwater, Minnesota, United States

Site Status

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, United States

Site Status

The West Clinic - Corinth

Corinth, Mississippi, United States

Site Status

Saint Francis Medical Center

Cape Girardeau, Missouri, United States

Site Status

Southeast Cancer Center

Cape Girardeau, Missouri, United States

Site Status

Saint Luke's Hospital

Chesterfield, Missouri, United States

Site Status

University of Missouri - Ellis Fischel

Columbia, Missouri, United States

Site Status

Barnes-Jewish West County Hospital

Creve Coeur, Missouri, United States

Site Status

Capital Region Medical Center-Goldschmidt Cancer Center

Jefferson City, Missouri, United States

Site Status

Truman Medical Center

Kansas City, Missouri, United States

Site Status

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, United States

Site Status

Kansas City Veterans Affairs Medical Center

Kansas City, Missouri, United States

Site Status

The University of Kansas Cancer Center-South

Kansas City, Missouri, United States

Site Status

Research Medical Center

Kansas City, Missouri, United States

Site Status

The University of Kansas Cancer Center-North

Kansas City, Missouri, United States

Site Status

The University of Kansas Cancer Center-Lee's Summit

Lee's Summit, Missouri, United States

Site Status

Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, United States

Site Status

Mercy Hospital Springfield

Springfield, Missouri, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Missouri Baptist Medical Center

St Louis, Missouri, United States

Site Status

Mercy Hospital Saint Louis

St Louis, Missouri, United States

Site Status

Community Hospital of Anaconda

Anaconda, Montana, United States

Site Status

Saint Vincent Healthcare

Billings, Montana, United States

Site Status

Bozeman Deaconess Hospital

Bozeman, Montana, United States

Site Status

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, United States

Site Status

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, United States

Site Status

Kalispell Regional Medical Center

Kalispell, Montana, United States

Site Status

CHI Health Saint Francis

Grand Island, Nebraska, United States

Site Status

CHI Health Good Samaritan

Kearney, Nebraska, United States

Site Status

Nebraska Hematology and Oncology

Lincoln, Nebraska, United States

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Southeast Nebraska Cancer Center

Lincoln, Nebraska, United States

Site Status

Nebraska Methodist Hospital

Omaha, Nebraska, United States

Site Status

HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, United States

Site Status

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, United States

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Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, United States

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Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, United States

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New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, United States

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Wentworth-Douglass Hospital

Dover, New Hampshire, United States

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New Hampshire Oncology Hematology PA-Hooksett

Hooksett, New Hampshire, United States

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LRGHealthcare-Lakes Region General Hospital

Laconia, New Hampshire, United States

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Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Site Status

Norris Cotton Cancer Center-Manchester

Manchester, New Hampshire, United States

Site Status

Saint Joseph Hospital

Nashua, New Hampshire, United States

Site Status

Norris Cotton Cancer Center-Nashua

Nashua, New Hampshire, United States

Site Status

Portsmouth Regional Hospital

Portsmouth, New Hampshire, United States

Site Status

Memorial Sloan Kettering Cancer Center at Basking Ridge

Basking Ridge, New Jersey, United States

Site Status

Veterans Adminstration New Jersey Health Care System

East Orange, New Jersey, United States

Site Status

Hackensack University Medical Center

Hackensack, New Jersey, United States

Site Status

Virtua Memorial

Mount Holly, New Jersey, United States

Site Status

The Valley Hospital-Luckow Pavilion

Paramus, New Jersey, United States

Site Status

Virtua Voorhees

Voorhees Township, New Jersey, United States

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Valley Health System-Hematology/Oncology

Westwood, New Jersey, United States

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University of New Mexico Cancer Center

Albuquerque, New Mexico, United States

Site Status

Memorial Medical Center - Las Cruces

Las Cruces, New Mexico, United States

Site Status

Christus Saint Vincent Regional Cancer Center

Santa Fe, New Mexico, United States

Site Status

Kings County Hospital

Brooklyn, New York, United States

Site Status

Maimonides Medical Center

Brooklyn, New York, United States

Site Status

Veterans Affairs Western New York Health Care System-Buffalo

Buffalo, New York, United States

Site Status

Roswell Park Cancer Institute

Buffalo, New York, United States

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Memorial Sloan Kettering Cancer Center Commack

Commack, New York, United States

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Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, United States

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Memorial Sloan-Kettering Cancer Center West Harrison

Harrison, New York, United States

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North Shore-LIJ Health System/Center for Advanced Medicine

New Hyde Park, New York, United States

Site Status

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, United States

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Columbia University/Herbert Irving Cancer Center

New York, New York, United States

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Memorial Sloan-Kettering Cancer Center

New York, New York, United States

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Weill Medical College of Cornell University

New York, New York, United States

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University of Rochester

Rochester, New York, United States

Site Status

Memorial Sloan Kettering Cancer Center Rockville Centre

Rockville Centre, New York, United States

Site Status

Memorial Sloan Kettering Cancer Center Sleepy Hollow

Sleepy Hollow, New York, United States

Site Status

Stony Brook University Medical Center

Stony Brook, New York, United States

Site Status

State University of New York Upstate Medical University

Syracuse, New York, United States

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Syracuse Veterans Administration Medical Center

Syracuse, New York, United States

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Montefiore Medical Center-Einstein Campus

The Bronx, New York, United States

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Montefiore Medical Center - Moses Campus

The Bronx, New York, United States

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Bronx Veterans Administration Medical Center

The Bronx, New York, United States

Site Status

Randolph Hospital

Asheboro, North Carolina, United States

Site Status

Cone Health Cancer Center at Alamance Regional

Burlington, North Carolina, United States

Site Status

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States

Site Status

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, United States

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Oncology Specialists of Charlotte

Charlotte, North Carolina, United States

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Southern Oncology Specialists-Charlotte

Charlotte, North Carolina, United States

Site Status

Durham Veterans Affairs Medical Center

Durham, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Wayne Memorial Hospital

Goldsboro, North Carolina, United States

Site Status

Cone Health Cancer Center

Greensboro, North Carolina, United States

Site Status

Lake Norman Hematology Oncology Specialists-Huntersville

Huntersville, North Carolina, United States

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Southern Oncology Specialists-Huntersville

Huntersville, North Carolina, United States

Site Status

Novant Health Oncology Specialists-Kernersville

Kernersville, North Carolina, United States

Site Status

Kinston Medical Specialists PA

Kinston, North Carolina, United States

Site Status

Novant Health Cancer Specialists-Matthews

Matthews, North Carolina, United States

Site Status

Lake Norman Hematology Oncology Specialists-Mooresville

Mooresville, North Carolina, United States

Site Status

Novant Health Oncology Specialists-Mount Airy

Mount Airy, North Carolina, United States

Site Status

Annie Penn Memorial Hospital

Reidsville, North Carolina, United States

Site Status

Carolina Oncology Associates PA

Salisbury, North Carolina, United States

Site Status

Veterans Administration Medical Center

Salisbury, North Carolina, United States

Site Status

Novant Health Oncology Specialists-Statesville

Statesville, North Carolina, United States

Site Status

Novant Health Oncology Specialists-Davidson County

Thomasville, North Carolina, United States

Site Status

Marion L Shepard Cancer Center at Vidant Beaufort Hospital

Washington, North Carolina, United States

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Novant Health Oncology Specialists-Wilkesboro

Wilkesboro, North Carolina, United States

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Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, United States

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Novant Health Oncology Specialists

Winston-Salem, North Carolina, United States

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Winston-Salem Health Care

Winston-Salem, North Carolina, United States

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Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Site Status

Sanford Bismarck Medical Center

Bismarck, North Dakota, United States

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Sanford Clinic North-Fargo

Fargo, North Dakota, United States

Site Status

Sanford Medical Center-Fargo

Fargo, North Dakota, United States

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Altru Cancer Center

Grand Forks, North Dakota, United States

Site Status

Trinity Cancer Care Center

Minot, North Dakota, United States

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Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, United States

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Summa Barberton Hospital

Barberton, Ohio, United States

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UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, United States

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Mercy Medical Center

Canton, Ohio, United States

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Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, United States

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Geaugra Hospital

Chardon, Ohio, United States

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University of Cincinnati/Barrett Cancer Center

Cincinnati, Ohio, United States

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Case Western Reserve University

Cleveland, Ohio, United States

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MetroHealth Medical Center

Cleveland, Ohio, United States

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Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, United States

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Cleveland Clinic Foundation

Cleveland, Ohio, United States

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Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status

The Mark H Zangmeister Center

Columbus, Ohio, United States

Site Status

Mount Carmel Health Center West

Columbus, Ohio, United States

Site Status

Good Samaritan Hospital - Dayton

Dayton, Ohio, United States

Site Status

Miami Valley Hospital

Dayton, Ohio, United States

Site Status

Samaritan North Health Center

Dayton, Ohio, United States

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Hematology Oncology Center Incorporated

Elyria, Ohio, United States

Site Status

Mercy Cancer Center-Elyria

Elyria, Ohio, United States

Site Status

Armes Family Cancer Center

Findlay, Ohio, United States

Site Status

Blanchard Valley Hospital

Findlay, Ohio, United States

Site Status

Orion Cancer Care

Findlay, Ohio, United States

Site Status

Cleveland Clinic Cancer Center Independence

Independence, Ohio, United States

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Greater Dayton Cancer Center

Kettering, Ohio, United States

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Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, United States

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Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, United States

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Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, United States

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Ireland Cancer Center Landerbrook Health Center

Mayfield Heights, Ohio, United States

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Summa Health Center at Lake Medina

Medina, Ohio, United States

Site Status

Lake University Ireland Cancer Center

Mentor, Ohio, United States

Site Status

Southwest General Health Center Ireland Cancer Center

Middleburg Heights, Ohio, United States

Site Status

University Hospitals Parma Medical Center

Parma, Ohio, United States

Site Status

Southern Ohio Medical Center

Portsmouth, Ohio, United States

Site Status

Ireland Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, United States

Site Status

North Coast Cancer Care

Sandusky, Ohio, United States

Site Status

Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, United States

Site Status

University of Toledo

Toledo, Ohio, United States

Site Status

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, United States

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University Hospitals Sharon Health Center

Wadsworth, Ohio, United States

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South Pointe Hospital

Warrensville Heights, Ohio, United States

Site Status

University Pointe

West Chester, Ohio, United States

Site Status

Saint Ann's Hospital

Westerville, Ohio, United States

Site Status

UH-Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, United States

Site Status

UHHS-Westlake Medical Center

Westlake, Ohio, United States

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Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, United States

Site Status

Wright-Patterson Medical Center

Wright-Patterson Air Force Base, Ohio, United States

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Cancer Centers of Southwest Oklahoma Research

Lawton, Oklahoma, United States

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University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

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Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, United States

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Oklahoma Cancer Specialists and Research Institute-Tulsa

Tulsa, Oklahoma, United States

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Good Samaritan Hospital

Corvallis, Oregon, United States

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Providence Milwaukie Hospital

Milwaukie, Oregon, United States

Site Status

Providence Newberg Medical Center

Newberg, Oregon, United States

Site Status

Providence Willamette Falls Medical Center

Oregon City, Oregon, United States

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Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, United States

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Providence Portland Medical Center

Portland, Oregon, United States

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Providence Saint Vincent Medical Center

Portland, Oregon, United States

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Kaiser Permanente Northwest

Portland, Oregon, United States

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Abington Memorial Hospital

Abington, Pennsylvania, United States

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Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, United States

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Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, United States

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Geisinger Medical Center

Danville, Pennsylvania, United States

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Adams Cancer Center

Gettysburg, Pennsylvania, United States

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Saint Mary Medical and Regional Cancer Center

Langhorne, Pennsylvania, United States

Site Status

Allegheny Valley Hospital

Natrona Heights, Pennsylvania, United States

Site Status

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

Site Status

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, United States

Site Status

WellSpan Health-York Hospital

York, Pennsylvania, United States

Site Status

Roger Williams Medical Center

Providence, Rhode Island, United States

Site Status

Roper Hospital

Charleston, South Carolina, United States

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Charleston Hematology Oncology Associates-Roper

Charleston, South Carolina, United States

Site Status

Lowcountry Hematology Oncology PA-North Charleston

Charleston, South Carolina, United States

Site Status

Bon Secours Saint Francis Hospital

Charleston, South Carolina, United States

Site Status

Charleston Hematology Oncology Associates PA-St. Francis

Charleston, South Carolina, United States

Site Status

Lowcountry Hematology Oncology PA-West Ashley

Charleston, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Easley

Easley, South Carolina, United States

Site Status

Saint Francis Hospital

Greenville, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Butternut

Greenville, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Faris

Greenville, South Carolina, United States

Site Status

Saint Francis Cancer Center

Greenville, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Eastside

Greenville, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Greer

Greer, South Carolina, United States

Site Status

Carolina Blood and Cancer Care Associates PA-Lancaster

Lancaster, South Carolina, United States

Site Status

Lowcountry Hematology Oncology PA-Mount Pleasant

Mt. Pleasant, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Seneca

Seneca, South Carolina, United States

Site Status

Greenville Health System Cancer Institute-Spartanburg

Spartanburg, South Carolina, United States

Site Status

Avera Cancer Institute-Aberdeen

Aberdeen, South Dakota, United States

Site Status

Rapid City Regional Hospital

Rapid City, South Dakota, United States

Site Status

Sanford Cancer Center-Oncology Clinic

Sioux Falls, South Dakota, United States

Site Status

Avera Cancer Institute

Sioux Falls, South Dakota, United States

Site Status

The West Clinic - Wolf River

Germantown, Tennessee, United States

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University of Tennessee Health Science Center

Memphis, Tennessee, United States

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Parkland Memorial Hospital

Dallas, Texas, United States

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UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States

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UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, United States

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University of Texas Medical Branch

Galveston, Texas, United States

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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, United States

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Ben Taub General Hospital

Houston, Texas, United States

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UTMB Cancer Center at Victory Lakes

League City, Texas, United States

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University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status

University of Vermont College of Medicine

Burlington, Vermont, United States

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White River Junction Veteran Administration Medical Center

White River Junction, Vermont, United States

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University of Virginia Cancer Center

Charlottesville, Virginia, United States

Site Status

Virginia Oncology Associates-Hampton

Hampton, Virginia, United States

Site Status

Lynchburg Hematology-Oncology Clinic

Lynchburg, Virginia, United States

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Memorial Hospital Of Martinsville

Martinsville, Virginia, United States

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Bon Secours Memorial Regional Medical Center

Mechanicsville, Virginia, United States

Site Status

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, United States

Site Status

Virginia Cancer Institute

Richmond, Virginia, United States

Site Status

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, United States

Site Status

Shenandoah Oncology Associates PC

Winchester, Virginia, United States

Site Status

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, United States

Site Status

Providence Regional Cancer Partnership

Everett, Washington, United States

Site Status

Swedish Cancer Institute-Issaquah

Issaquah, Washington, United States

Site Status

Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, United States

Site Status

Minor and James Medical PLLC

Seattle, Washington, United States

Site Status

Swedish Medical Center-First Hill

Seattle, Washington, United States

Site Status

West Virginia University Charleston

Charleston, West Virginia, United States

Site Status

Saint Mary's Medical Center

Huntington, West Virginia, United States

Site Status

Langlade Hospital and Cancer Center

Antigo, Wisconsin, United States

Site Status

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, United States

Site Status

Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, United States

Site Status

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, United States

Site Status

Sacred Heart Hospital

Eau Claire, Wisconsin, United States

Site Status

Saint Agnes Hospital/Agnesian Cancer Center

Fond du Lac, Wisconsin, United States

Site Status

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, United States

Site Status

Aurora Cancer Care-Grafton

Grafton, Wisconsin, United States

Site Status

Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, United States

Site Status

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, United States

Site Status

Green Bay Oncology Limited at Saint Mary's Hospital

Green Bay, Wisconsin, United States

Site Status

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, United States

Site Status

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States

Site Status

Mercy Health System

Janesville, Wisconsin, United States

Site Status

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, United States

Site Status

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, United States

Site Status

William S Middleton VA Medical Center

Madison, Wisconsin, United States

Site Status

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, United States

Site Status

Holy Family Memorial Hospital

Manitowoc, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Marinette

Marinette, Wisconsin, United States

Site Status

Marshfield Clinic

Marshfield, Wisconsin, United States

Site Status

Saint Joseph's Hospital

Marshfield, Wisconsin, United States

Site Status

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, United States

Site Status

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, United States

Site Status

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Aurora Sinai Medical Center

Milwaukee, Wisconsin, United States

Site Status

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, United States

Site Status

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, United States

Site Status

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, United States

Site Status

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, United States

Site Status

Green Bay Oncology - Oconto Falls

Oconto Falls, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, United States

Site Status

Wheaton Franciscan Cancer Care - All Saints

Racine, Wisconsin, United States

Site Status

Aurora Cancer Care-Racine

Racine, Wisconsin, United States

Site Status

Marshfield Clinic-Rice Lake Center

Rice Lake, Wisconsin, United States

Site Status

HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, United States

Site Status

Marshfield Clinic Cancer Care at Saint Michael's Hospital

Stevens Point, Wisconsin, United States

Site Status

Saint Michael's Hospital

Stevens Point, Wisconsin, United States

Site Status

Green Bay Oncology - Sturgeon Bay

Sturgeon Bay, Wisconsin, United States

Site Status

Aurora Medical Center in Summit

Summit, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, United States

Site Status

Aurora Cancer Care-Waukesha

Waukesha, Wisconsin, United States

Site Status

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, United States

Site Status

Aspirus Regional Cancer Center

Wausau, Wisconsin, United States

Site Status

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, United States

Site Status

Aurora West Allis Medical Center

West Allis, Wisconsin, United States

Site Status

Diagnostic and Treatment Center

Weston, Wisconsin, United States

Site Status

Marshfield Clinic - Weston Center

Weston, Wisconsin, United States

Site Status

Aspirus UW Cancer Center

Wisconsin Rapids, Wisconsin, United States

Site Status

Cross Cancer Institute

Edmonton, Alberta, Canada

Site Status

BCCA-Vancouver Cancer Centre

Vancouver, British Columbia, Canada

Site Status

The Moncton Hospital

Moncton, New Brunswick, Canada

Site Status

The Vitalite Health Network - Dr Leon Richard Oncology Centre

Moncton, New Brunswick, Canada

Site Status

Atlantic Health Sciences Corporation-Saint John Regional Hospital

Saint John, New Brunswick, Canada

Site Status

Doctor H. Bliss Murphy Cancer Centre

St. John's, Newfoundland and Labrador, Canada

Site Status

Cambridge Memorial Hospital

Cambridge, Ontario, Canada

Site Status

Grand River Regional Cancer Centre at Grand River Hospital

Kitchener, Ontario, Canada

Site Status

Allan Blair Cancer Centre

Regina, Saskatchewan, Canada

Site Status

San Juan Veterans Affairs Medical Center

San Juan, , Puerto Rico

Site Status

Fundacion De Investigacion de Diego

San Juan, , Puerto Rico

Site Status

San Juan City Hospital

San Juan, , Puerto Rico

Site Status

Countries

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United States Canada Puerto Rico

References

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Knutson TP, Luo B, Kobilka A, Lyman J, Guo S, Munro SA, Li Y, Heer R, Gaughan L, Morris MJ, Beltran H, Ryan CJ, Antonarakis ES, Armstrong AJ, Halabi S, Dehm SM. AR alterations inform circulating tumor DNA detection in metastatic castration resistant prostate cancer patients. Nat Commun. 2024 Dec 11;15(1):10648. doi: 10.1038/s41467-024-54847-1.

Reference Type DERIVED
PMID: 39663356 (View on PubMed)

Morris MJ, Heller G, Hillman DW, Bobek O, Ryan C, Antonarakis ES, Bryce AH, Hahn O, Beltran H, Armstrong AJ, Schwartz L, Lewis LD, Beumer JH, Langevin B, McGary EC, Mehan PT, Goldkorn A, Roth BJ, Xiao H, Watt C, Taplin ME, Halabi S, Small EJ. Randomized Phase III Study of Enzalutamide Compared With Enzalutamide Plus Abiraterone for Metastatic Castration-Resistant Prostate Cancer (Alliance A031201 Trial). J Clin Oncol. 2023 Jun 20;41(18):3352-3362. doi: 10.1200/JCO.22.02394. Epub 2023 Mar 30.

Reference Type DERIVED
PMID: 36996380 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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U10CA031946

Identifier Type: NIH

Identifier Source: secondary_id

View Link

NCI-2013-01737

Identifier Type: REGISTRY

Identifier Source: secondary_id

A031201

Identifier Type: -

Identifier Source: org_study_id

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