Identification of Correlations Between Reaction to Biotine and Autoimmune Diseases
NCT ID: NCT01934764
Last Updated: 2013-09-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
60 participants
OBSERVATIONAL
2013-09-30
Brief Summary
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A. Assessment of the possibility that biotin elicit immune response involved in the developmental stage of the autoimmune disease.
B. Assessment of the possibility that anti-biotin antibodies indicate the developmental stage of the autoimmune disease and therefore can serve as an disease early stage marker.
Methods: A. Patient recruitment. Gathering participant's medical record and blood samples. B. Records of clinical and biochemical measures. C. Serum of all patient will be tested for the correlation between biotin level, biotin bound to antibodies and anti-biotin antibodies to liver functions tests. D. Controlled test for repeatedly injected mice with biotinilated self-antibodies. Level of anti-biotin will be tested and their influence on the mouse. E. Determination of the correlation between biotinilated antibodies or anti-biotin antibodies to disease eruption or severance and autoimmune disease.
Expected results :Serum biotin-protein levels and Anti biotin antibodies levels are increased in patients with active autoimmune liver diseases.
Importance: The proof of connection between biotin-carrying immunoglobulins, anti biotin antibodies and autoimmune diseases will open new research direction of possible factors that cause to autoimmune disease.
Probable implications to Medicine: Identification of correlations between reaction to biotine and autoimmune diseases will enable their usage as biomarkers for autoimmune diseases, severity of the disease and personalization of treatment.
Detailed Description
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Conditions
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Study Design
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PROSPECTIVE
Study Groups
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autoimmune disease
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Autoimmune disease
18 Years
ALL
No
Sponsors
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Ziv Hospital
OTHER_GOV
Responsible Party
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Assy Nimer
MD
Locations
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Ziv Medical Center
Safed, , Israel
Countries
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Central Contacts
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Facility Contacts
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Nimer Assy, MD
Role: primary
Other Identifiers
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0027-13-ziv
Identifier Type: -
Identifier Source: org_study_id