Trial Outcomes & Findings for A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors (NCT NCT01928394)

NCT ID: NCT01928394

Last Updated: 2024-12-27

Results Overview

The number of participants with a best overall response (BOR) of complete response (CR) or partial response (PR) divided by the number of treated participants.

Recruitment status

COMPLETED

Study phase

PHASE1/PHASE2

Target enrollment

1163 participants

Primary outcome timeframe

60 months

Results posted on

2024-12-27

Participant Flow

1131 participants were treated in total for TNBC, GC, PC, SCLC, BC and OC.

Participant milestones

Participant milestones
Measure
TNBC Arm N
Triple Negative Breast Cancer (TNBC) Nivolumab monotherapy (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 1
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 2
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N
Gastric Cancer (GC) Nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 1
Gastric Cancer(GC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N-I Dose Level 2
Gastric Cancer (GC) nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses; then nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 2b
Gastric Cancer (GC) Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg Q2W
PC Arm N-I Dose Level 1
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2d
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q6W for 4 doses + cobimetinib 60 mg po qd 21 days on/7 days off
SCLC Arm N - Pre-expansion
Small cell lung cancer (SCLC) participants treated in Pre-expansion Cohort with Nivolumab 3 mg/kg Q2W
SCLC Arm N-I Dose Level 2 - Pre-expansion
Small cell lung cancer (SCLC) treated participants in Pre-expansion cohort treated with Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N Expansion
Small cell lung cancer (SCLC) expansion cohort participants: Nivolumab monotherapy (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 2- Expansion
Small cell lung cancer (SCLC) expansion cohort participants Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 1 -
Small cell lung cancer (SCLC) participants treated with Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3mg/kg) Q2W
SCLC Arm N-I Dose Level 2b
Small cell lung cancer (SCLC) treated participants treated with Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
BC Arm N
Bladder cancer (BC) participants: Nivolumab 3 mg/kg Q2W
BC Arm N-I Dose Level 2
Bladder cancer (BC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
BC Arm N-I Dose Level 2b
Bladder cancer (BC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2
Ovarian cancer (OC) participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2b
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses,then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2c:
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) Q2W + ipilimumab (1 mg/kg) Q6W
Treatment Period
STARTED
18
3
18
59
3
49
52
18
3
18
30
98
61
147
96
3
55
78
92
104
41
43
42
Treatment Period
Transition
3
0
0
9
0
0
0
2
0
0
0
17
0
2
0
0
0
20
0
0
0
0
0
Treatment Period
Transition- Continued
0
0
3
0
0
3
6
0
1
1
0
0
17
0
2
0
0
0
1
19
0
0
0
Treatment Period
COMPLETED
0
0
0
3
0
6
3
0
0
0
0
5
6
8
8
1
5
7
22
8
1
1
3
Treatment Period
NOT COMPLETED
18
3
18
56
3
43
49
18
3
18
30
93
55
139
88
2
50
71
70
96
40
42
39
Follow-up Period
STARTED
15
3
18
50
3
49
52
16
3
18
30
81
61
145
96
3
55
58
92
104
41
43
42
Follow-up Period
COMPLETED
12
3
15
40
3
41
40
10
2
16
19
59
47
107
66
3
41
50
76
83
32
34
36
Follow-up Period
NOT COMPLETED
3
0
3
10
0
8
12
6
1
2
11
22
14
38
30
0
14
8
16
21
9
9
6

Reasons for withdrawal

Reasons for withdrawal
Measure
TNBC Arm N
Triple Negative Breast Cancer (TNBC) Nivolumab monotherapy (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 1
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 2
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N
Gastric Cancer (GC) Nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 1
Gastric Cancer(GC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N-I Dose Level 2
Gastric Cancer (GC) nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses; then nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 2b
Gastric Cancer (GC) Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg Q2W
PC Arm N-I Dose Level 1
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2d
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q6W for 4 doses + cobimetinib 60 mg po qd 21 days on/7 days off
SCLC Arm N - Pre-expansion
Small cell lung cancer (SCLC) participants treated in Pre-expansion Cohort with Nivolumab 3 mg/kg Q2W
SCLC Arm N-I Dose Level 2 - Pre-expansion
Small cell lung cancer (SCLC) treated participants in Pre-expansion cohort treated with Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N Expansion
Small cell lung cancer (SCLC) expansion cohort participants: Nivolumab monotherapy (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 2- Expansion
Small cell lung cancer (SCLC) expansion cohort participants Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 1 -
Small cell lung cancer (SCLC) participants treated with Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3mg/kg) Q2W
SCLC Arm N-I Dose Level 2b
Small cell lung cancer (SCLC) treated participants treated with Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
BC Arm N
Bladder cancer (BC) participants: Nivolumab 3 mg/kg Q2W
BC Arm N-I Dose Level 2
Bladder cancer (BC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
BC Arm N-I Dose Level 2b
Bladder cancer (BC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2
Ovarian cancer (OC) participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2b
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses,then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2c:
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) Q2W + ipilimumab (1 mg/kg) Q6W
Treatment Period
Disease progression
17
2
12
48
3
25
38
16
3
11
22
73
38
118
59
1
43
56
50
71
30
31
31
Treatment Period
Study drug toxicity
1
1
3
3
0
9
7
1
0
5
2
3
7
5
12
0
3
3
12
15
4
7
4
Treatment Period
AE unrelated to study drug
0
0
2
3
0
5
1
0
0
2
0
12
6
13
6
1
1
6
3
5
1
1
0
Treatment Period
Participant request to stop therapy
0
0
0
0
0
3
3
0
0
0
3
2
1
2
4
0
1
3
1
1
3
1
3
Treatment Period
Participant withdrew consent
0
0
1
1
0
1
0
1
0
0
1
1
1
0
2
0
2
1
1
1
0
2
0
Treatment Period
Poor/non-compliance
0
0
0
1
0
0
0
0
0
0
0
0
1
0
1
0
0
1
0
1
0
0
0
Treatment Period
other reason
0
0
0
0
0
0
0
0
0
0
1
1
1
0
1
0
0
0
2
2
0
0
0
Treatment Period
Maximum clinical benefit
0
0
0
0
0
0
0
0
0
0
1
1
0
0
1
0
0
1
1
0
2
0
0
Treatment Period
Lost to Follow-up
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
Treatment Period
Death
0
0
0
0
0
0
0
0
0
0
0
0
0
1
2
0
0
0
0
0
0
0
0
Follow-up Period
Participant withdrew consent
3
0
1
4
0
2
5
1
0
0
5
8
2
12
7
0
5
3
2
7
4
6
2
Follow-up Period
Death
0
0
2
6
0
6
6
2
1
2
4
12
11
25
18
0
6
5
13
13
5
3
2
Follow-up Period
other reason
0
0
0
0
0
0
1
3
0
0
2
1
0
1
4
0
2
0
1
1
0
0
1
Follow-up Period
Lost to Follow-up
0
0
0
0
0
0
0
0
0
0
0
1
1
0
1
0
1
0
0
0
0
0
1

Baseline Characteristics

All Treated Participants

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
TNBC Arm N
n=18 Participants
Triple Negative Breast Cancer (TNBC) Nivolumab monotherapy (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 1
n=3 Participants
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 2
n=18 Participants
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N
n=59 Participants
Gastric Cancer (GC) Nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 1
n=3 Participants
Gastric Cancer(GC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N-I Dose Level 2
n=49 Participants
Gastric Cancer (GC) nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses; then nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 2b
n=52 Participants
Gastric Cancer (GC) Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N
n=18 Participants
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg Q2W
PC Arm N-I Dose Level 1
n=3 Participants
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2
n=18 Participants
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2d
n=30 Participants
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q6W for 4 doses + cobimetinib 60 mg po qd 21 days on/7 days off
SCLC Arm N - Pre-expansion
n=98 Participants
Small cell lung cancer (SCLC) participants treated in Pre-expansion Cohort with Nivolumab 3 mg/kg Q2W
SCLC Arm N-I Dose Level 2 - Pre-expansion
n=61 Participants
Small cell lung cancer (SCLC) treated participants in Pre-expansion cohort treated with Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N Expansion
n=147 Participants
Small cell lung cancer (SCLC) expansion cohort participants:Nivolumab monotherapy (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 2- Expansion
n=96 Participants
Small cell lung cancer (SCLC) expansion cohort participants Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2Wi
SCLC Arm N-I Dose Level 1 -
n=3 Participants
Small cell lung cancer (SCLC) participants treated with Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3mg/kg) Q2W
SCLC Arm N-I Dose Level 2b
n=55 Participants
Small cell lung cancer (SCLC) treated participants treated with Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
BC Arm N
n=78 Participants
Bladder cancer (BC) participants: Nivolumab 3 mg/kg Q2W
BC Arm N-I Dose Level 2
n=92 Participants
Bladder cancer (BC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
BC Arm N-I Dose Level 2b
n=104 Participants
Bladder cancer (BC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2
n=41 Participants
Ovarian cancer (OC) participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2b:
n=43 Participants
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses,then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2c:
n=42 Participants
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) Q2W + ipilimumab (1 mg/kg) Q6W
Total
n=1131 Participants
Total of all reporting groups
Age, Continuous
53.3 Years
STANDARD_DEVIATION 11.9 • n=5 Participants • All Treated Participants
52.7 Years
STANDARD_DEVIATION 9.5 • n=7 Participants • All Treated Participants
49.1 Years
STANDARD_DEVIATION 9.0 • n=5 Participants • All Treated Participants
57.2 Years
STANDARD_DEVIATION 10.99 • n=4 Participants • All Treated Participants
67.0 Years
STANDARD_DEVIATION 9.54 • n=21 Participants • All Treated Participants
53.2 Years
STANDARD_DEVIATION 12.58 • n=8 Participants • All Treated Participants
56.4 Years
STANDARD_DEVIATION 13.40 • n=8 Participants • All Treated Participants
63.2 Years
STANDARD_DEVIATION 9.70 • n=24 Participants • All Treated Participants
58.3 Years
STANDARD_DEVIATION 9.87 • n=42 Participants • All Treated Participants
64.1 Years
STANDARD_DEVIATION 9.21 • n=42 Participants • All Treated Participants
62.1 Years
STANDARD_DEVIATION 11.51 • n=42 Participants • All Treated Participants
62.6 Years
STANDARD_DEVIATION 8.50 • n=42 Participants • All Treated Participants
63.9 Years
STANDARD_DEVIATION 9.94 • n=36 Participants • All Treated Participants
62.8 Years
STANDARD_DEVIATION 9.09 • n=36 Participants • All Treated Participants
63.7 Years
STANDARD_DEVIATION 9.06 • n=24 Participants • All Treated Participants
59.3 Years
STANDARD_DEVIATION 6.7 • n=135 Participants • All Treated Participants
60.1 Years
STANDARD_DEVIATION 7.74 • n=136 Participants • All Treated Participants
64.1 Years
STANDARD_DEVIATION 10.86 • n=44 Participants • All Treated Participants
63.9 Years
STANDARD_DEVIATION 9.54 • n=667 Participants • All Treated Participants
64.1 Years
STANDARD_DEVIATION 9.69 • n=12 Participants • All Treated Participants
56.7 Years
STANDARD_DEVIATION 11.1 • n=12 Participants • All Treated Participants
59.6 Years
STANDARD_DEVIATION 10.9 • n=12 Participants • All Treated Participants
58.7 Years
STANDARD_DEVIATION 12.2 • n=12 Participants • All Treated Participants
61.2 Years
STANDARD_DEVIATION 10.7 • n=11 Participants • All Treated Participants
Age, Customized
< 65
16 Participants
n=5 Participants • All Treated Participants
3 Participants
n=7 Participants • All Treated Participants
18 Participants
n=5 Participants • All Treated Participants
42 Participants
n=4 Participants • All Treated Participants
1 Participants
n=21 Participants • All Treated Participants
39 Participants
n=8 Participants • All Treated Participants
35 Participants
n=8 Participants • All Treated Participants
5 Participants
n=24 Participants • All Treated Participants
2 Participants
n=42 Participants • All Treated Participants
9 Participants
n=42 Participants • All Treated Participants
13 Participants
n=42 Participants • All Treated Participants
55 Participants
n=42 Participants • All Treated Participants
27 Participants
n=36 Participants • All Treated Participants
82 Participants
n=36 Participants • All Treated Participants
47 Participants
n=24 Participants • All Treated Participants
2 Participants
n=135 Participants • All Treated Participants
38 Participants
n=136 Participants • All Treated Participants
37 Participants
n=44 Participants • All Treated Participants
47 Participants
n=667 Participants • All Treated Participants
57 Participants
n=12 Participants • All Treated Participants
30 Participants
n=12 Participants • All Treated Participants
26 Participants
n=12 Participants • All Treated Participants
25 Participants
n=12 Participants • All Treated Participants
656 Participants
n=11 Participants • All Treated Participants
Age, Customized
>= 65 and < 75
1 Participants
n=5 Participants • All Treated Participants
0 Participants
n=7 Participants • All Treated Participants
0 Participants
n=5 Participants • All Treated Participants
15 Participants
n=4 Participants • All Treated Participants
1 Participants
n=21 Participants • All Treated Participants
8 Participants
n=8 Participants • All Treated Participants
12 Participants
n=8 Participants • All Treated Participants
12 Participants
n=24 Participants • All Treated Participants
1 Participants
n=42 Participants • All Treated Participants
7 Participants
n=42 Participants • All Treated Participants
14 Participants
n=42 Participants • All Treated Participants
34 Participants
n=42 Participants • All Treated Participants
27 Participants
n=36 Participants • All Treated Participants
51 Participants
n=36 Participants • All Treated Participants
39 Participants
n=24 Participants • All Treated Participants
1 Participants
n=135 Participants • All Treated Participants
17 Participants
n=136 Participants • All Treated Participants
31 Participants
n=44 Participants • All Treated Participants
34 Participants
n=667 Participants • All Treated Participants
29 Participants
n=12 Participants • All Treated Participants
10 Participants
n=12 Participants • All Treated Participants
14 Participants
n=12 Participants • All Treated Participants
12 Participants
n=12 Participants • All Treated Participants
370 Participants
n=11 Participants • All Treated Participants
Age, Customized
>= 75
1 Participants
n=5 Participants • All Treated Participants
0 Participants
n=7 Participants • All Treated Participants
0 Participants
n=5 Participants • All Treated Participants
2 Participants
n=4 Participants • All Treated Participants
1 Participants
n=21 Participants • All Treated Participants
2 Participants
n=8 Participants • All Treated Participants
5 Participants
n=8 Participants • All Treated Participants
1 Participants
n=24 Participants • All Treated Participants
0 Participants
n=42 Participants • All Treated Participants
2 Participants
n=42 Participants • All Treated Participants
3 Participants
n=42 Participants • All Treated Participants
9 Participants
n=42 Participants • All Treated Participants
7 Participants
n=36 Participants • All Treated Participants
14 Participants
n=36 Participants • All Treated Participants
10 Participants
n=24 Participants • All Treated Participants
0 Participants
n=135 Participants • All Treated Participants
0 Participants
n=136 Participants • All Treated Participants
10 Participants
n=44 Participants • All Treated Participants
11 Participants
n=667 Participants • All Treated Participants
18 Participants
n=12 Participants • All Treated Participants
1 Participants
n=12 Participants • All Treated Participants
3 Participants
n=12 Participants • All Treated Participants
5 Participants
n=12 Participants • All Treated Participants
105 Participants
n=11 Participants • All Treated Participants
Age, Customized
>= 65
2 Participants
n=5 Participants • All Treated Participants
0 Participants
n=7 Participants • All Treated Participants
0 Participants
n=5 Participants • All Treated Participants
17 Participants
n=4 Participants • All Treated Participants
2 Participants
n=21 Participants • All Treated Participants
10 Participants
n=8 Participants • All Treated Participants
17 Participants
n=8 Participants • All Treated Participants
13 Participants
n=24 Participants • All Treated Participants
1 Participants
n=42 Participants • All Treated Participants
9 Participants
n=42 Participants • All Treated Participants
17 Participants
n=42 Participants • All Treated Participants
43 Participants
n=42 Participants • All Treated Participants
34 Participants
n=36 Participants • All Treated Participants
65 Participants
n=36 Participants • All Treated Participants
49 Participants
n=24 Participants • All Treated Participants
1 Participants
n=135 Participants • All Treated Participants
17 Participants
n=136 Participants • All Treated Participants
41 Participants
n=44 Participants • All Treated Participants
45 Participants
n=667 Participants • All Treated Participants
47 Participants
n=12 Participants • All Treated Participants
11 Participants
n=12 Participants • All Treated Participants
17 Participants
n=12 Participants • All Treated Participants
17 Participants
n=12 Participants • All Treated Participants
475 Participants
n=11 Participants • All Treated Participants
Sex: Female, Male
Female
18 Participants
n=5 Participants • All treated Participants
3 Participants
n=7 Participants • All treated Participants
18 Participants
n=5 Participants • All treated Participants
14 Participants
n=4 Participants • All treated Participants
1 Participants
n=21 Participants • All treated Participants
15 Participants
n=8 Participants • All treated Participants
7 Participants
n=8 Participants • All treated Participants
5 Participants
n=24 Participants • All treated Participants
2 Participants
n=42 Participants • All treated Participants
8 Participants
n=42 Participants • All treated Participants
12 Participants
n=42 Participants • All treated Participants
37 Participants
n=42 Participants • All treated Participants
26 Participants
n=36 Participants • All treated Participants
61 Participants
n=36 Participants • All treated Participants
35 Participants
n=24 Participants • All treated Participants
1 Participants
n=135 Participants • All treated Participants
23 Participants
n=136 Participants • All treated Participants
24 Participants
n=44 Participants • All treated Participants
18 Participants
n=667 Participants • All treated Participants
23 Participants
n=12 Participants • All treated Participants
41 Participants
n=12 Participants • All treated Participants
43 Participants
n=12 Participants • All treated Participants
42 Participants
n=12 Participants • All treated Participants
477 Participants
n=11 Participants • All treated Participants
Sex: Female, Male
Male
0 Participants
n=5 Participants • All treated Participants
0 Participants
n=7 Participants • All treated Participants
0 Participants
n=5 Participants • All treated Participants
45 Participants
n=4 Participants • All treated Participants
2 Participants
n=21 Participants • All treated Participants
34 Participants
n=8 Participants • All treated Participants
45 Participants
n=8 Participants • All treated Participants
13 Participants
n=24 Participants • All treated Participants
1 Participants
n=42 Participants • All treated Participants
10 Participants
n=42 Participants • All treated Participants
18 Participants
n=42 Participants • All treated Participants
61 Participants
n=42 Participants • All treated Participants
35 Participants
n=36 Participants • All treated Participants
86 Participants
n=36 Participants • All treated Participants
61 Participants
n=24 Participants • All treated Participants
2 Participants
n=135 Participants • All treated Participants
32 Participants
n=136 Participants • All treated Participants
54 Participants
n=44 Participants • All treated Participants
74 Participants
n=667 Participants • All treated Participants
81 Participants
n=12 Participants • All treated Participants
0 Participants
n=12 Participants • All treated Participants
0 Participants
n=12 Participants • All treated Participants
0 Participants
n=12 Participants • All treated Participants
654 Participants
n=11 Participants • All treated Participants
Ethnicity (NIH/OMB)
Hispanic or Latino
0 Participants
n=5 Participants • All Treated Participants
0 Participants
n=7 Participants • All Treated Participants
0 Participants
n=5 Participants • All Treated Participants
1 Participants
n=4 Participants • All Treated Participants
0 Participants
n=21 Participants • All Treated Participants
1 Participants
n=8 Participants • All Treated Participants
2 Participants
n=8 Participants • All Treated Participants
0 Participants
n=24 Participants • All Treated Participants
0 Participants
n=42 Participants • All Treated Participants
1 Participants
n=42 Participants • All Treated Participants
0 Participants
n=42 Participants • All Treated Participants
3 Participants
n=42 Participants • All Treated Participants
0 Participants
n=36 Participants • All Treated Participants
0 Participants
n=36 Participants • All Treated Participants
0 Participants
n=24 Participants • All Treated Participants
0 Participants
n=135 Participants • All Treated Participants
1 Participants
n=136 Participants • All Treated Participants
2 Participants
n=44 Participants • All Treated Participants
0 Participants
n=667 Participants • All Treated Participants
4 Participants
n=12 Participants • All Treated Participants
1 Participants
n=12 Participants • All Treated Participants
1 Participants
n=12 Participants • All Treated Participants
1 Participants
n=12 Participants • All Treated Participants
18 Participants
n=11 Participants • All Treated Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
10 Participants
n=5 Participants • All Treated Participants
3 Participants
n=7 Participants • All Treated Participants
9 Participants
n=5 Participants • All Treated Participants
41 Participants
n=4 Participants • All Treated Participants
2 Participants
n=21 Participants • All Treated Participants
29 Participants
n=8 Participants • All Treated Participants
35 Participants
n=8 Participants • All Treated Participants
16 Participants
n=24 Participants • All Treated Participants
3 Participants
n=42 Participants • All Treated Participants
13 Participants
n=42 Participants • All Treated Participants
28 Participants
n=42 Participants • All Treated Participants
63 Participants
n=42 Participants • All Treated Participants
47 Participants
n=36 Participants • All Treated Participants
97 Participants
n=36 Participants • All Treated Participants
55 Participants
n=24 Participants • All Treated Participants
2 Participants
n=135 Participants • All Treated Participants
26 Participants
n=136 Participants • All Treated Participants
59 Participants
n=44 Participants • All Treated Participants
38 Participants
n=667 Participants • All Treated Participants
73 Participants
n=12 Participants • All Treated Participants
26 Participants
n=12 Participants • All Treated Participants
29 Participants
n=12 Participants • All Treated Participants
32 Participants
n=12 Participants • All Treated Participants
736 Participants
n=11 Participants • All Treated Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
8 Participants
n=5 Participants • All Treated Participants
0 Participants
n=7 Participants • All Treated Participants
9 Participants
n=5 Participants • All Treated Participants
17 Participants
n=4 Participants • All Treated Participants
1 Participants
n=21 Participants • All Treated Participants
19 Participants
n=8 Participants • All Treated Participants
15 Participants
n=8 Participants • All Treated Participants
2 Participants
n=24 Participants • All Treated Participants
0 Participants
n=42 Participants • All Treated Participants
4 Participants
n=42 Participants • All Treated Participants
2 Participants
n=42 Participants • All Treated Participants
32 Participants
n=42 Participants • All Treated Participants
14 Participants
n=36 Participants • All Treated Participants
50 Participants
n=36 Participants • All Treated Participants
41 Participants
n=24 Participants • All Treated Participants
1 Participants
n=135 Participants • All Treated Participants
28 Participants
n=136 Participants • All Treated Participants
17 Participants
n=44 Participants • All Treated Participants
54 Participants
n=667 Participants • All Treated Participants
27 Participants
n=12 Participants • All Treated Participants
14 Participants
n=12 Participants • All Treated Participants
13 Participants
n=12 Participants • All Treated Participants
9 Participants
n=12 Participants • All Treated Participants
377 Participants
n=11 Participants • All Treated Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=7 Participants • All Treated Participnats
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=4 Participants • All Treated Participnats
0 Participants
n=21 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
1 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=135 Participants • All Treated Participnats
0 Participants
n=136 Participants • All Treated Participnats
0 Participants
n=44 Participants • All Treated Participnats
0 Participants
n=667 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
1 Participants
n=11 Participants • All Treated Participnats
Race (NIH/OMB)
Asian
1 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=7 Participants • All Treated Participnats
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=4 Participants • All Treated Participnats
0 Participants
n=21 Participants • All Treated Participnats
1 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
1 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
1 Participants
n=42 Participants • All Treated Participnats
1 Participants
n=42 Participants • All Treated Participnats
1 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
2 Participants
n=36 Participants • All Treated Participnats
1 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=135 Participants • All Treated Participnats
0 Participants
n=136 Participants • All Treated Participnats
1 Participants
n=44 Participants • All Treated Participnats
1 Participants
n=667 Participants • All Treated Participnats
4 Participants
n=12 Participants • All Treated Participnats
2 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
1 Participants
n=12 Participants • All Treated Participnats
18 Participants
n=11 Participants • All Treated Participnats
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=7 Participants • All Treated Participnats
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=4 Participants • All Treated Participnats
0 Participants
n=21 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=135 Participants • All Treated Participnats
0 Participants
n=136 Participants • All Treated Participnats
0 Participants
n=44 Participants • All Treated Participnats
0 Participants
n=667 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=11 Participants • All Treated Participnats
Race (NIH/OMB)
Black or African American
3 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=7 Participants • All Treated Participnats
1 Participants
n=5 Participants • All Treated Participnats
3 Participants
n=4 Participants • All Treated Participnats
0 Participants
n=21 Participants • All Treated Participnats
1 Participants
n=8 Participants • All Treated Participnats
1 Participants
n=8 Participants • All Treated Participnats
1 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
1 Participants
n=42 Participants • All Treated Participnats
4 Participants
n=42 Participants • All Treated Participnats
3 Participants
n=42 Participants • All Treated Participnats
1 Participants
n=36 Participants • All Treated Participnats
7 Participants
n=36 Participants • All Treated Participnats
5 Participants
n=24 Participants • All Treated Participnats
1 Participants
n=135 Participants • All Treated Participnats
0 Participants
n=136 Participants • All Treated Participnats
4 Participants
n=44 Participants • All Treated Participnats
3 Participants
n=667 Participants • All Treated Participnats
4 Participants
n=12 Participants • All Treated Participnats
1 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
2 Participants
n=12 Participants • All Treated Participnats
46 Participants
n=11 Participants • All Treated Participnats
Race (NIH/OMB)
White
14 Participants
n=5 Participants • All Treated Participnats
3 Participants
n=7 Participants • All Treated Participnats
17 Participants
n=5 Participants • All Treated Participnats
56 Participants
n=4 Participants • All Treated Participnats
3 Participants
n=21 Participants • All Treated Participnats
46 Participants
n=8 Participants • All Treated Participnats
50 Participants
n=8 Participants • All Treated Participnats
16 Participants
n=24 Participants • All Treated Participnats
3 Participants
n=42 Participants • All Treated Participnats
16 Participants
n=42 Participants • All Treated Participnats
23 Participants
n=42 Participants • All Treated Participnats
91 Participants
n=42 Participants • All Treated Participnats
60 Participants
n=36 Participants • All Treated Participnats
134 Participants
n=36 Participants • All Treated Participnats
87 Participants
n=24 Participants • All Treated Participnats
2 Participants
n=135 Participants • All Treated Participnats
54 Participants
n=136 Participants • All Treated Participnats
72 Participants
n=44 Participants • All Treated Participnats
87 Participants
n=667 Participants • All Treated Participnats
90 Participants
n=12 Participants • All Treated Participnats
37 Participants
n=12 Participants • All Treated Participnats
43 Participants
n=12 Participants • All Treated Participnats
38 Participants
n=12 Participants • All Treated Participnats
1042 Participants
n=11 Participants • All Treated Participnats
Race (NIH/OMB)
More than one race
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=7 Participants • All Treated Participnats
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=4 Participants • All Treated Participnats
0 Participants
n=21 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=135 Participants • All Treated Participnats
0 Participants
n=136 Participants • All Treated Participnats
0 Participants
n=44 Participants • All Treated Participnats
0 Participants
n=667 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=11 Participants • All Treated Participnats
Race (NIH/OMB)
Unknown or Not Reported
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=7 Participants • All Treated Participnats
0 Participants
n=5 Participants • All Treated Participnats
0 Participants
n=4 Participants • All Treated Participnats
0 Participants
n=21 Participants • All Treated Participnats
1 Participants
n=8 Participants • All Treated Participnats
1 Participants
n=8 Participants • All Treated Participnats
0 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=42 Participants • All Treated Participnats
2 Participants
n=42 Participants • All Treated Participnats
2 Participants
n=42 Participants • All Treated Participnats
0 Participants
n=36 Participants • All Treated Participnats
4 Participants
n=36 Participants • All Treated Participnats
3 Participants
n=24 Participants • All Treated Participnats
0 Participants
n=135 Participants • All Treated Participnats
1 Participants
n=136 Participants • All Treated Participnats
1 Participants
n=44 Participants • All Treated Participnats
1 Participants
n=667 Participants • All Treated Participnats
6 Participants
n=12 Participants • All Treated Participnats
1 Participants
n=12 Participants • All Treated Participnats
0 Participants
n=12 Participants • All Treated Participnats
1 Participants
n=12 Participants • All Treated Participnats
24 Participants
n=11 Participants • All Treated Participnats

PRIMARY outcome

Timeframe: 60 months

Population: All Treated Participants

The number of participants with a best overall response (BOR) of complete response (CR) or partial response (PR) divided by the number of treated participants.

Outcome measures

Outcome measures
Measure
TNBC Arm N
n=18 Participants
Triple Negative Breast Cancer (TNBC) Nivolumab monotherapy (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 1
n=3 Participants
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 2
n=18 Participants
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N
n=59 Participants
Gastric Cancer (GC) Nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 1
n=3 Participants
Gastric Cancer(GC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N-I Dose Level 2
n=49 Participants
Gastric Cancer (GC) nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses; then nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 2b
n=52 Participants
Gastric Cancer (GC) Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N
n=18 Participants
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg Q2W
PC Arm N-I Dose Level 1
n=3 Participants
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2
n=18 Participants
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2d
n=30 Participants
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q6W for 4 doses + cobimetinib 60 mg po qd 21 days on/7 days off
SCLC Arm N - Pre-expansion
n=98 Participants
Small cell lung cancer (SCLC) participants treated in Pre-expansion Cohort with Nivolumab 3 mg/kg Q2W
SCLC Arm N-I Dose Level 2 - Pre-expansion
n=61 Participants
Small cell lung cancer (SCLC) treated participants in Pre-expansion cohort treated with Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N Expansion
n=147 Participants
Small cell lung cancer (SCLC) expansion cohort participants:Nivolumab monotherapy (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 2- Expansion
n=96 Participants
Small cell lung cancer (SCLC) expansion cohort participants Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2Wi
SCLC Arm N-I Dose Level 1 -
n=3 Participants
Small cell lung cancer (SCLC) participants treated with Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3mg/kg) Q2W
SCLC Arm N-I Dose Level 2b
n=55 Participants
Small cell lung cancer (SCLC) treated participants treated with Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
SCLC Arm N- All Treated
n=245 Participants
Small cell lung cancer (SCLC) for all treated participants with Nivolumab 3 mg/kg Q2W
SCLC Arm N-I Dose Level 2 - All Treated
n=157 Participants
Small cell lung cancer (SCLC) all treated participants with Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses
BC Arm N
n=78 Participants
Bladder cancer (BC) participants: Nivolumab 3 mg/kg Q2W
BC Arm N-I Dose Level 2
n=92 Participants
Bladder cancer (BC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
BC Arm N-I Dose Level 2b
n=104 Participants
Bladder cancer (BC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2
n=41 Participants
Ovarian cancer (OC) participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2b:
n=43 Participants
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses,then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2c:
n=42 Participants
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) Q2W + ipilimumab (1 mg/kg) Q6W
Objective Response Rate ( ORR )
5.6 Percentage of Participants
Interval 0.1 to 27.3
0.0 Percentage of Participants
Interval 0.0 to 70.8
0.0 Percentage of Participants
Interval 0.0 to 18.5
11.9 Percentage of Participants
Interval 4.9 to 22.9
0.0 Percentage of Participants
Interval 0.0 to 70.8
24.5 Percentage of Participants
Interval 13.3 to 38.9
7.7 Percentage of Participants
Interval 2.1 to 18.5
0.0 Percentage of Participants
Interval 0.0 to 18.5
0.0 Percentage of Participants
Interval 0.0 to 70.8
0.0 Percentage of Participants
Interval 0.0 to 18.5
6.7 Percentage of Participants
Interval 0.8 to 22.1
13.3 Percentage of Participants
Interval 7.3 to 21.6
26.2 Percentage of Participants
Interval 15.8 to 39.1
11.6 Percentage of Participants
Interval 6.9 to 17.9
21.9 Percentage of Participants
Interval 14.1 to 31.5
33.3 Percentage of Participants
Interval 0.8 to 90.6
18.2 Percentage of Participants
Interval 9.1 to 30.9
11.8 Percentage of Participants
Interval 8.1 to 16.6
22.3 Percentage of Participants
Interval 16.0 to 29.6
25.6 Percentage of Participants
Interval 16.4 to 36.8
38.0 Percentage of Participants
Interval 28.1 to 48.8
26.9 Percentage of Participants
Interval 18.7 to 36.5
12.2 Percentage of Participants
Interval 4.1 to 26.2
7.0 Percentage of Participants
Interval 1.5 to 19.1
9.5 Percentage of Participants
Interval 2.7 to 22.6

Adverse Events

TNBC Arm N

Serious events: 9 serious events
Other events: 18 other events
Deaths: 17 deaths

TNBC Arm N-I Dose Level 1

Serious events: 2 serious events
Other events: 3 other events
Deaths: 3 deaths

TNBC Arm N-I Dose Level 2

Serious events: 11 serious events
Other events: 17 other events
Deaths: 18 deaths

GC Arm N

Serious events: 32 serious events
Other events: 58 other events
Deaths: 53 deaths

GC Arm N-I Dose Level 1

Serious events: 1 serious events
Other events: 3 other events
Deaths: 3 deaths

GC Arm N-I Dose Level 2

Serious events: 37 serious events
Other events: 47 other events
Deaths: 42 deaths

GC Arm N-I Dose Level 2b

Serious events: 34 serious events
Other events: 49 other events
Deaths: 50 deaths

PC Arm N

Serious events: 10 serious events
Other events: 18 other events
Deaths: 18 deaths

PC Arm N-I Dose Level 1

Serious events: 3 serious events
Other events: 3 other events
Deaths: 3 deaths

PC Arm N-I Dose Level 2

Serious events: 11 serious events
Other events: 17 other events
Deaths: 18 deaths

PC Arm N-I Dose Level 2d

Serious events: 16 serious events
Other events: 29 other events
Deaths: 24 deaths

SCLC Arm N

Serious events: 129 serious events
Other events: 226 other events
Deaths: 212 deaths

SCLC Arm N-I Dose Level 2

Serious events: 111 serious events
Other events: 147 other events
Deaths: 136 deaths

SCLC Arm N-I Dose Level 1

Serious events: 2 serious events
Other events: 3 other events
Deaths: 3 deaths

SCLC Arm N-I Dose Level 2b

Serious events: 32 serious events
Other events: 53 other events
Deaths: 45 deaths

BC Arm N

Serious events: 41 serious events
Other events: 77 other events
Deaths: 60 deaths

BC Arm N-I Dose Level 2

Serious events: 62 serious events
Other events: 85 other events
Deaths: 54 deaths

BC Arm N-I Dose Level 2b

Serious events: 72 serious events
Other events: 100 other events
Deaths: 82 deaths

OC Arm N-I Dose Level 2

Serious events: 24 serious events
Other events: 38 other events
Deaths: 33 deaths

OC Arm N-I Dose Level 2b

Serious events: 31 serious events
Other events: 40 other events
Deaths: 37 deaths

OC Arm N-I Dose Level 2c

Serious events: 29 serious events
Other events: 41 other events
Deaths: 34 deaths

Serious adverse events

Serious adverse events
Measure
TNBC Arm N
n=18 participants at risk
Triple Negative Breast Cancer (TNBC) Nivolumab monotherapy (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 1
n=3 participants at risk
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 2
n=18 participants at risk
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N
n=59 participants at risk
Gastric Cancer (GC) Nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 1
n=3 participants at risk
Gastric Cancer(GC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N-I Dose Level 2
n=49 participants at risk
Gastric Cancer (GC) nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses; then nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 2b
n=52 participants at risk
Gastric Cancer (GC) Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N
n=18 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg Q2W
PC Arm N-I Dose Level 1
n=3 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2
n=18 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2d
n=30 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q6W for 4 doses + cobimetinib 60 mg po qd 21 days on/7 days off
SCLC Arm N
n=245 participants at risk
Small cell lung cancer (SCLC) pre-expansion and expansion cohort participants: Nivolumab monotherapy (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 2
n=157 participants at risk
Small cell lung cancer (SCLC) pre-expansion and expansion cohort participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2Wi
SCLC Arm N-I Dose Level 1
n=3 participants at risk
Small cell lung cancer (SCLC) participants treated with Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3mg/kg) Q2W
SCLC Arm N-I Dose Level 2b
n=55 participants at risk
Small cell lung cancer (SCLC) treated participants treated with Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
BC Arm N
n=78 participants at risk
Bladder cancer (BC) participants: Nivolumab 3 mg/kg Q2W
BC Arm N-I Dose Level 2
n=92 participants at risk
Bladder cancer (BC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
BC Arm N-I Dose Level 2b
n=104 participants at risk
Bladder cancer (BC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2
n=41 participants at risk
Ovarian cancer (OC) participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2b
n=43 participants at risk
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses,then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2c
n=42 participants at risk
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) Q2W + ipilimumab (1 mg/kg) Q6W
Renal and urinary disorders
Urinary retention
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Urinary tract obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Dysfunctional uterine bleeding
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Vaginal discharge
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Vaginal haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Acute respiratory distress syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Chronic obstructive pulmonary disease
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Cough
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Dyspnoea
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
8/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Epistaxis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Aspiration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Haemoptysis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Hypoxia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Cutaneous lupus erythematosus
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Hyperhidrosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Pemphigoid
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Rash
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Rash maculo-papular
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Interstitial lung disease
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pleural effusion
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pneumonia aspiration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pneumonitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pneumothorax
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pulmonary embolism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pulmonary oedema
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Respiratory distress
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Respiratory failure
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Deep vein thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Embolism
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Hypertension
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Oesophageal fistula
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Peritonitis bacterial
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Pain in extremity
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Prerenal failure
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Renal disorder
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Renal failure
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Urethral obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Anaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Blood loss anaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Febrile neutropenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Leukocytosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Neutropenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Thrombocytopenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Acute coronary syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Acute myocardial infarction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Angina pectoris
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Arrhythmia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Atrial fibrillation
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Atrial tachycardia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Atrioventricular block
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Atrioventricular block complete
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Cardiac arrest
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Cardiac failure
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Cardiac failure congestive
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Cardiac tamponade
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Myocardial infarction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Myocarditis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Palpitations
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Pericardial effusion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Pericardial haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Pericarditis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Sinus tachycardia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Supraventricular tachycardia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Tachycardia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Ventricular arrhythmia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Ventricular tachycardia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Ear and labyrinth disorders
Hypoacusis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Adrenal insufficiency
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Autoimmune thyroiditis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hyperthyroidism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hypophysitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hypopituitarism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hypothyroidism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Inappropriate antidiuretic hormone secretion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Thyroiditis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Diplopia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Endocrine ophthalmopathy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Eye pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Vision blurred
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal distension
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal hernia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Ascites
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Autoimmune colitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Cheilitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Chronic gastritis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Colitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Colonic fistula
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Constipation
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Diarrhoea
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
5/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.9%
10/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
7/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Duodenal obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Dysphagia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Enteritis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Enterocolitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastric haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastric ulcer
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastritis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastritis haemorrhagic
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastrointestinal pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Haematemesis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Hiatus hernia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Ileus
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Immune-mediated enterocolitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Intestinal obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Intestinal pseudo-obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Large intestinal obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Lower gastrointestinal haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Mouth ulceration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Nausea
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Obstruction gastric
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Oesophageal obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Oesophageal stenosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Oral pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Pancreatitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Pancreatitis chronic
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Proctalgia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Rectal haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Small intestinal obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Stomatitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Subileus
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Upper gastrointestinal haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Vomiting
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Adverse event
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Asthenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Chest pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Cyst
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Disease progression
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Fatigue
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Gait disturbance
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
General physical health deterioration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Malaise
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Multiple organ dysfunction syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Non-cardiac chest pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Oedema peripheral
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Pyrexia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
7/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Sudden death
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Systemic inflammatory response syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Autoimmune hepatitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Bile duct obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Cholangitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Cholecystitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Cholecystitis acute
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Drug-induced liver injury
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Hepatic failure
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Hepatic pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Hepatitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Hyperbilirubinaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Steatohepatitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Immune system disorders
Drug hypersensitivity
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Immune system disorders
Haemophagocytic lymphohistiocytosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Immune system disorders
Hypersensitivity
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Abdominal abscess
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Abdominal infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Abdominal sepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Arthritis infective
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Aspergillus infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Bacterial sepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Biliary sepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Candida infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Cellulitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Clostridium difficile infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Cystitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Device related infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Diarrhoea infectious
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Encephalitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Enterocolitis infectious
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Escherichia sepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Gastroenteritis viral
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Herpes zoster
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Kidney infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Lower respiratory tract infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Lung infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Meningitis aseptic
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Neutropenic sepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Osteomyelitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Peritoneal abscess
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Pneumonia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.3%
13/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Pneumonia viral
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Pyelonephritis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Respiratory tract infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Respiratory tract infection viral
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Rhinovirus infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Salmonellosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Sepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Sinusitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Skin infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Systemic candida
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Upper respiratory tract infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Urinary tract infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Urosepsis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Vascular device infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Viral diarrhoea
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Anaesthetic complication neurological
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Ankle fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Fall
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Femur fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Gastrointestinal stoma complication
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Hip fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Infusion related reaction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Overdose
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Post procedural haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Radiation injury
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Rib fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Spinal compression fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Spinal fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Subdural haematoma
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Upper limb fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Alanine aminotransferase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.2%
4/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Amylase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Aspartate aminotransferase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood alkaline phosphatase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood bilirubin increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood creatinine increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Haemoglobin decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Lipase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Liver function test increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Platelet count decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Transaminases increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
White blood cell count decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Alkalosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Decreased appetite
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Dehydration
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Electrolyte imbalance
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Failure to thrive
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyperammonaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypercalcaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyperglycaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyperkalaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypokalaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypomagnesaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyponatraemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypophosphataemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Tumour lysis syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Type 3 diabetes mellitus
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Arthralgia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Back pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Bone lesion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Bone pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Flank pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Intervertebral disc degeneration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Muscular weakness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Neck pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Osteoarthritis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Pathological fracture
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Polymyositis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Rhabdomyolysis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Spinal stenosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Bladder cancer
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Cancer pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Colorectal adenocarcinoma
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Infected neoplasm
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Keratoacanthoma
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Lymphangiosis carcinomatosa
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Malignant neoplasm progression
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.3%
9/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
7/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
54/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.3%
35/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.6%
13/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.1%
13/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
10/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Malignant pleural effusion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Metastases to central nervous system
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Metastases to meninges
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Metastatic neoplasm
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Neoplasm progression
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Paraneoplastic syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Squamous cell carcinoma
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Tumour haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Tumour pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Cerebral haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Cerebral infarction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Cerebral ischaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Cerebrovascular accident
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Dizziness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Encephalopathy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Epilepsy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Facial paralysis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Haemorrhage intracranial
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Headache
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Limbic encephalitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Myasthenia gravis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Myasthenic syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Paraesthesia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Paraparesis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Posterior reversible encephalopathy syndrome
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Presyncope
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Radiculopathy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Seizure
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Spinal cord compression
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Syncope
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Transient ischaemic attack
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Product Issues
Device leakage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Confusional state
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Delirium
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Disorientation
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Hallucination
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Mental status changes
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Substance-induced psychotic disorder
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Acute kidney injury
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Chronic kidney disease
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Dysuria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Haematuria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Haemorrhage urinary tract
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Hydronephrosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Nephrolithiasis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Hypotension
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Jugular vein thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Lymphoedema
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Peripheral arterial occlusive disease
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Poor venous access
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Superior vena cava syndrome
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Venous thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy

Other adverse events

Other adverse events
Measure
TNBC Arm N
n=18 participants at risk
Triple Negative Breast Cancer (TNBC) Nivolumab monotherapy (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 1
n=3 participants at risk
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
TNBC Arm N-I Dose Level 2
n=18 participants at risk
Triple Negative Breast Cancer (TNBC) Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N
n=59 participants at risk
Gastric Cancer (GC) Nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 1
n=3 participants at risk
Gastric Cancer(GC) Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
GC Arm N-I Dose Level 2
n=49 participants at risk
Gastric Cancer (GC) nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses; then nivolumab 3 mg/kg Q2W
GC Arm N-I Dose Level 2b
n=52 participants at risk
Gastric Cancer (GC) Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N
n=18 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg Q2W
PC Arm N-I Dose Level 1
n=3 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2
n=18 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
PC Arm N-I Dose Level 2d
n=30 participants at risk
Pancreatic cancer (PC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q6W for 4 doses + cobimetinib 60 mg po qd 21 days on/7 days off
SCLC Arm N
n=245 participants at risk
Small cell lung cancer (SCLC) pre-expansion and expansion cohort participants: Nivolumab monotherapy (3 mg/kg) Q2W
SCLC Arm N-I Dose Level 2
n=157 participants at risk
Small cell lung cancer (SCLC) pre-expansion and expansion cohort participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2Wi
SCLC Arm N-I Dose Level 1
n=3 participants at risk
Small cell lung cancer (SCLC) participants treated with Nivolumab (1 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3mg/kg) Q2W
SCLC Arm N-I Dose Level 2b
n=55 participants at risk
Small cell lung cancer (SCLC) treated participants treated with Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
BC Arm N
n=78 participants at risk
Bladder cancer (BC) participants: Nivolumab 3 mg/kg Q2W
BC Arm N-I Dose Level 2
n=92 participants at risk
Bladder cancer (BC) participants: Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
BC Arm N-I Dose Level 2b
n=104 participants at risk
Bladder cancer (BC) participants: Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg Q3W for 4 doses, then Nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2
n=41 participants at risk
Ovarian cancer (OC) participants: Nivolumab (1 mg/kg) + ipilimumab (3 mg/kg) Q3W for 4 doses, then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2b
n=43 participants at risk
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) + ipilimumab (1 mg/kg) Q3W for 4 doses,then nivolumab (3 mg/kg) Q2W
OC Arm N-I Dose Level 2c
n=42 participants at risk
Ovarian cancer (OC) participants: Nivolumab (3 mg/kg) Q2W + ipilimumab (1 mg/kg) Q6W
Blood and lymphatic system disorders
Leukopenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Lymphopenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Immune system disorders
Seasonal allergy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Bacterial disease carrier
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Bronchitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Candida infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Musculoskeletal pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.5%
8/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
9/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Upper-airway cough syndrome
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
7/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Anaemia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
32.2%
19/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
24.5%
12/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
32.7%
17/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
44.4%
8/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.1%
37/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.6%
26/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.2%
10/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
34.6%
27/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.6%
18/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
28.8%
30/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.3%
10/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.0%
8/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Leukocytosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Neutropenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Blood and lymphatic system disorders
Thrombocytopenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.9%
6/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Atrial fibrillation
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Palpitations
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Sinus tachycardia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Cardiac disorders
Tachycardia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Ear and labyrinth disorders
Ear pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Ear and labyrinth disorders
Vertigo
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Adrenal insufficiency
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
5/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Autoimmune thyroiditis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hyperthyroidism
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.2%
4/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
7/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.0%
22/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
9/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.5%
13/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hypogonadism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Hypothyroidism
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
6/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.7%
14/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.3%
24/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.9%
6/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
9/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.2%
14/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.4%
16/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.1%
7/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.3%
10/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.0%
8/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Inappropriate antidiuretic hormone secretion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Thyroid disorder
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Endocrine disorders
Thyroiditis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Diplopia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Dry eye
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Eye discharge
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Keratitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Lacrimation increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Photopsia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Eye disorders
Vision blurred
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.5%
6/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal discomfort
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal distension
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
6/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
7/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal pain
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
28.8%
17/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.3%
9/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
5/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.9%
17/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.1%
19/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.9%
6/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.9%
14/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
15/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.2%
21/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
41.5%
17/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
44.2%
19/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.2%
11/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Abdominal pain upper
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
7/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
5/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
6/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Ascites
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.6%
8/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.2%
4/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
7/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
7/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
6/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Colitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.7%
9/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Constipation
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.4%
15/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.4%
9/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.8%
16/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
5/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.0%
49/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.7%
34/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.8%
12/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.5%
16/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.7%
19/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.9%
28/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
9/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
32.6%
14/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.8%
10/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Diarrhoea
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
61.1%
11/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
28.8%
17/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.6%
15/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.4%
8/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
55.6%
10/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
70.0%
21/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
54/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
28.7%
45/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.9%
17/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.8%
17/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
47.8%
44/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
36.5%
38/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
31.7%
13/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
44.2%
19/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.1%
16/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Dry mouth
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
7/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
12/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.0%
11/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.5%
13/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
5/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Dyspepsia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.4%
5/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Dysphagia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.3%
9/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.0%
13/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
8/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Flatulence
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastrointestinal haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Gastrooesophageal reflux disease
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Haematemesis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Haematochezia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Haemorrhoids
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Impaired gastric emptying
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Nausea
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
35.6%
21/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
100.0%
3/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.6%
15/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.9%
14/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
55.6%
10/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
40.0%
12/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.4%
55/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
24.2%
38/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.9%
17/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
29.5%
23/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.2%
25/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
31.7%
33/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
39.0%
16/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
48.8%
21/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
42.9%
18/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Oral pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Rectal haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Small intestinal obstruction
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Steatorrhoea
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Stomatitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.6%
7/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Tongue disorder
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Toothache
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Gastrointestinal disorders
Vomiting
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.5%
18/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.4%
9/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.8%
16/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
50.0%
15/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.1%
37/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.6%
26/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.0%
11/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
13/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.7%
19/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.3%
19/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
9/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.2%
13/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.2%
11/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Asthenia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
5/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
7/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.4%
28/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.1%
19/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.8%
12/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.4%
5/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Chest pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.3%
13/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Chills
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
5/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
8/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.0%
11/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Early satiety
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Face oedema
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Facial pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Fatigue
44.4%
8/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
54.2%
32/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
44.9%
22/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
53.8%
28/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
61.1%
11/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
72.2%
13/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
73.3%
22/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
36.3%
89/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
42.7%
67/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
45.5%
25/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
59.0%
46/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
39.1%
36/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
50.0%
52/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
51.2%
21/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
55.8%
24/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
64.3%
27/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Gait disturbance
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
General physical health deterioration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Hyperpyrexia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Influenza like illness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
7/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Localised oedema
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Malaise
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Mucosal inflammation
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Nodule
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Non-cardiac chest pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
11/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Oedema
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Oedema peripheral
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
7/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
5/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
6/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.0%
9/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
18/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.1%
19/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
13/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.6%
18/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.2%
22/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.1%
7/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.6%
8/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
5/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
6/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
10/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.0%
12/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
12/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Peripheral swelling
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Pyrexia
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.1%
16/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.4%
10/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.9%
14/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
40.0%
12/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.7%
14/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.7%
20/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.1%
11/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
31.5%
29/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
17/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
9/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.9%
9/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
7/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Temperature intolerance
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Tenderness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
General disorders
Thirst
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Hyperbilirubinaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Hepatobiliary disorders
Portal vein thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Immune system disorders
Hypersensitivity
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Cellulitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Conjunctivitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Helicobacter gastritis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Herpes virus infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Herpes zoster
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Hordeolum
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Mucosal infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.4%
5/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Nasopharyngitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
7/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Oral candidiasis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Pharyngitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Pneumonia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Respiratory tract infection
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Sinusitis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Skin infection
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Tonsillitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Upper respiratory tract infection
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
12/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
9/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Infections and infestations
Urinary tract infection
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
12/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.9%
14/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.9%
10/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
12/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.0%
8/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Accidental device ingestion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Contusion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Fall
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
11/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Infusion related reaction
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.7%
14/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Post procedural inflammation
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Injury, poisoning and procedural complications
Skin laceration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Activated partial thromboplastin time
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Alanine aminotransferase increased
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
6/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.4%
11/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.6%
26/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.7%
20/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
15/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.2%
20/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
9/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.3%
4/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.4%
9/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Amylase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.7%
14/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
18/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
9/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.4%
15/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Aspartate aminotransferase increased
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.6%
8/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.4%
9/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.0%
27/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.9%
25/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.0%
11/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.3%
19/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.5%
8/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.0%
6/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.8%
10/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood alkaline phosphatase increased
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
6/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
5/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
15/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.3%
13/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.4%
15/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood bilirubin increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
8/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
7/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood calcium decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood creatinine increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
10/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.5%
16/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
8/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.4%
16/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood lactic acid increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood pressure increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood urea increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Blood uric acid increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
C-reactive protein increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Gamma-glutamyltransferase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Hepatic enzyme increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
International normalised ratio increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Lipase increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.6%
21/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
15/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.9%
14/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
9/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.4%
15/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.3%
4/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Liver function test increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Lymphocyte count decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Platelet count decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.6%
11/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Transaminases increased
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Troponin increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Weight decreased
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.6%
8/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.4%
8/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
15/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.3%
24/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.7%
7/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.0%
23/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.4%
16/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.3%
4/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
5/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
Weight increased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Investigations
White blood cell count decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Decreased appetite
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
35.6%
21/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
28.6%
14/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
36.5%
19/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
36.7%
11/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.3%
67/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
31.8%
50/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.3%
15/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.9%
14/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.8%
21/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
34.6%
36/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
24.4%
10/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.6%
11/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
31.0%
13/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Dehydration
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.3%
9/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.7%
14/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
15/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.6%
5/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyperglycaemia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
8/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.1%
18/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.5%
6/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.0%
26/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyperkalaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
10/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
8/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyperuricaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypoalbuminaemia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
6/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
6/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
7/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
12/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.0%
6/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypocalcaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
6/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
8/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypokalaemia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
7/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
18/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.3%
13/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.6%
7/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypomagnesaemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.8%
19/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.8%
17/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.7%
7/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.0%
11/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.4%
15/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.6%
5/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.0%
8/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hyponatraemia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
6/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.2%
4/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
7/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.5%
38/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.1%
19/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.4%
15/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
5/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
5/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Hypophosphataemia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Metabolism and nutrition disorders
Polydipsia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Arthralgia
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.9%
10/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
6/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.5%
38/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
18/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.4%
9/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.9%
21/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.0%
12/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.3%
18/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.6%
8/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
7/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Arthropathy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Back pain
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.6%
11/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.2%
10/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
5/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
30/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.2%
16/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.8%
17/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.7%
20/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.2%
22/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.6%
8/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Bone pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Flank pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Joint range of motion decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Joint swelling
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Muscle spasms
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
7/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Muscle tightness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Muscular weakness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.0%
11/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Musculoskeletal chest pain
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Myalgia
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
7/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.7%
9/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
6/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.5%
6/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
7/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Neck pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.4%
5/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Pain in extremity
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.3%
13/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
11/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.8%
10/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Musculoskeletal and connective tissue disorders
Spinal pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Tumour pain
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Amnesia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Ataxia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Disturbance in attention
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Dizziness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
5/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
12/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
18/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.5%
8/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
9/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.6%
5/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Dysaesthesia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Dysgeusia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
10/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.5%
6/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Freezing phenomenon
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Headache
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
7/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.3%
7/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.6%
21/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.9%
25/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.1%
11/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
15/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.6%
5/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.2%
11/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Hypogeusia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Lethargy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Memory impairment
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Migraine
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Mononeuropathy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Neuralgia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Neuropathy peripheral
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Paraesthesia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Peripheral motor neuropathy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Peripheral sensory neuropathy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.6%
7/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
4/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Polyneuropathy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Syncope
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Nervous system disorders
Taste disorder
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Agitation
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
66.7%
2/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Anxiety
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
11/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
8/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
7/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Confusional state
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
10/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Depression
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.7%
9/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Insomnia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.6%
8/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
7/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.0%
22/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
18/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.3%
8/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.0%
12/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
14/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Irritability
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Psychiatric disorders
Libido decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Acute kidney injury
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.4%
5/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Dysuria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Haematuria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.2%
15/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.8%
9/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.6%
11/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Micturition frequency decreased
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Pollakiuria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.2%
5/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Proteinuria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Renal and urinary disorders
Urinary retention
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Breast haemorrhage
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Gynaecomastia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Nipple exudate bloody
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Reproductive system and breast disorders
Pelvic pain
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Bronchospasm
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Chronic obstructive pulmonary disease
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Cough
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.8%
5/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.9%
7/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
8/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.1%
12/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.7%
8/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.0%
44/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.5%
40/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.3%
15/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
24.4%
19/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
18.5%
17/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.3%
18/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
6/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.6%
5/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.4%
9/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Dysphonia
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
10/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Dyspnoea
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.3%
9/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.3%
9/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
23.3%
7/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.0%
49/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.6%
26/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.5%
14/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
25.6%
20/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.6%
18/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.5%
14/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
19.5%
8/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.3%
4/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
14/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Dyspnoea exertional
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
10.0%
3/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Epistaxis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
3/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Haemoptysis
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
8/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Hiccups
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Nasal congestion
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
4/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.3%
4/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.3%
4/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
7/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Nasal dryness
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Obstructive airways disorder
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Oropharyngeal pain
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
5/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pleural effusion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.6%
5/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
15/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
10/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.3%
4/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pneumonitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
5/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Productive cough
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
6/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pulmonary embolism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Pulmonary pain
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Rhinorrhoea
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
3/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.4%
5/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.6%
7/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Sinus congestion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Sputum discoloured
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Respiratory, thoracic and mediastinal disorders
Wheezing
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.6%
4/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Alopecia
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
4/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Dermatitis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
4/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Dermatitis acneiform
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.7%
8/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Dermatitis contact
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Dermatitis exfoliative generalised
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Dry skin
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.3%
13/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
8/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.1%
11/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.5%
6/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.4%
15/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.2%
5/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Eczema
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Erythema
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.2%
3/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Hyperhidrosis
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
3/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
3/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Night sweats
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.1%
2/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
3/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.6%
7/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Pruritus
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.2%
4/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
22.0%
13/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
26.5%
13/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
30.8%
16/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
38.9%
7/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
36.7%
11/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.9%
34/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.4%
43/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.5%
8/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
35.9%
28/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
34.8%
32/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
32.7%
34/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
41.5%
17/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
27.9%
12/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.4%
9/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Pruritus generalised
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Rash
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
6/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
8.5%
5/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
20.4%
10/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
17.3%
9/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.7%
3/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
40.0%
12/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
15/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
15.9%
25/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.7%
7/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.7%
6/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
15/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
12.5%
13/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.6%
5/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.5%
4/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Rash maculo-papular
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
3/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
33.3%
1/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
8/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.5%
6/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
13.3%
4/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
12/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.6%
23/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
9.1%
5/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
24.4%
19/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
16.3%
15/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
21.2%
22/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
31.7%
13/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
14.3%
6/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Skin lesion
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.5%
3/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.96%
1/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Skin mass
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Skin ulcer
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Swelling face
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Skin and subcutaneous tissue disorders
Urticaria
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Deep vein thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.82%
2/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Embolism
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.8%
6/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Haematoma
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
1/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Hot flush
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.7%
1/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.41%
1/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.3%
2/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.0%
3/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.1%
3/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Hypertension
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.4%
2/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.0%
1/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.7%
2/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.9%
7/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.5%
4/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.6%
2/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.2%
2/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
2/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.7%
2/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.4%
1/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Hypotension
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.8%
4/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
6.1%
3/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.8%
2/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
3.3%
1/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
11/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.5%
7/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.8%
1/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.1%
4/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.4%
5/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
5/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
7.3%
3/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.3%
1/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Lymphoedema
11.1%
2/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
2.6%
2/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.9%
2/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
4.8%
2/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.9%
1/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.64%
1/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
Vascular disorders
Venous thrombosis
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
5.6%
1/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/59 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/49 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/52 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/18 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/30 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/245 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/157 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/3 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/55 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/78 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
1.1%
1/92 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/104 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/41 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/43 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy
0.00%
0/42 • Includes events reported between first dose and 30 days (AEs) or 100 days (SAEs) after last dose of study therapy

Additional Information

Bristol-Myers Squibb Study Director

Bristol-Myers Squibb

Phone: Please email

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place

Restriction type: GT60