Registry of Major Liver Resections Including ALPPS and Other Liver Resections in Two Stages
NCT ID: NCT01924741
Last Updated: 2014-07-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
500 participants
OBSERVATIONAL
2013-08-31
2016-12-31
Brief Summary
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Since the procedure is used worldwide this international registry was created to enable tracking of cases performed worldwide for safety and outcomes and innovations by the groups involved as well as allows a non-randomized comparison to the conventional methods of portal vein occlusion.
Detailed Description
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All data submitted are anonymized before entry through the SECUTRIAL Software. Administration of the registry data is performed through the Department of Visceral and Transplantation Surgery in the University Hospital Zurich and the Clinical Trials Center of the University of Zurich, Switzerland, in collaboration with the Italian Hospital in Buenoas Aires, Argentina.
A Scientific Committee has been appointed to give approval for any data analysis. Any participating center may apply for data analysis.
Particiating International Centers have responsibility for the validity of the data submitted and the respective local institutional review procedures.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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ALPPS
ALPPS is the most recent modification of the techniques developed for Two-stage hepatectomies. ALPPS allows to remove an extensive part of the liver in two steps. In the first step the liver parenchyma is transected along the intended line of resection and the future liver remnant cleaned by partial resections from all tumor tissue in the case of bilobar tumors. To this a portal ligation of the larger liver lobe that will have to be removed is added. After a waiting period of 1-2 weeks the second step is performed in which the deportalized liver is removed to render the patient completely tumor-free. (Ann Surg 2012; 255(3):405-14.)
ALPPS
Other procedures related to ALPPS like banding of the parechyma with portal vein ligation etc.
Interventions
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ALPPS
Other procedures related to ALPPS like banding of the parechyma with portal vein ligation etc.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients undergoing any other modification of ALPPS like portal vein embolization (PVE) or banding of the liver with portal vein ligation or embolisation or other liver resection in two stages resembling ALPPS\_
* Male and Female patients 18 years to no limit
* Prior registering the data, patient was informed and did not object to the use of his/her anonymized medical data in this registry
18 Years
ALL
No
Sponsors
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University of Zurich
OTHER
Responsible Party
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Principal Investigators
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Pierre Alain Clavien, Prof, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Zurich
Locations
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University Hospital Zurich
Zurich, Canton of Zurich, Switzerland
Countries
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References
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Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baumgart J, Farkas SA, Fichtner-Feigl S, Lorf T, Goralcyk A, Horbelt R, Kroemer A, Loss M, Rummele P, Scherer MN, Padberg W, Konigsrainer A, Lang H, Obed A, Schlitt HJ. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012 Mar;255(3):405-14. doi: 10.1097/SLA.0b013e31824856f5.
Reese T, Fard-Aghaie MH, Makridis G, Kantas A, Wagner KC, Malago M, Robles-Campos R, Hernandez-Alejandro R, de Santibanes E, Clavien PA, Petrowsky H, Linecker M, Oldhafer KJ. Renal Impairment Is Associated with Reduced Outcome After Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy. J Gastrointest Surg. 2020 Nov;24(11):2500-2507. doi: 10.1007/s11605-019-04419-2. Epub 2019 Nov 19.
Related Links
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Click here to receive more information about ALPPS registry and studies
Other Identifiers
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ALPPS registry
Identifier Type: -
Identifier Source: org_study_id