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Systemic Inflammatory Response Syndrome (SIRS) in Patients Undergoing Major Procedures in Oral and Maxillofacial Surgery

NCT ID: NCT01921049

Last Updated: 2014-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

27 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-09-30

Brief Summary

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Patients undergoing major procedures in oral and maxillofacial surgery more often develop a systemic inflammatory response syndrome (SIRS) in the first days of postoperative critical care therapy than patients with a comparable major surgery in other regions. The reasons for this finding are unknown and have not been studied in depth so far. We hypothesize that surgical trauma in this region might activate pro-inflammatory pathways. By examining the proteome of patients at different stages (prior to the surgery, at ICU admission, on the second postoperative day and when SIRS has ended clinically), we aim to identify the involved pro-inflammatory pathways and identify possible target proteins that might be clues to modification of postoperative SIRS in the future.

Detailed Description

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Conditions

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Systemic Inflammatory Response Syndrome (SIRS)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* age 18-99yrs
* scheduled for elective surgery with risk for development of SIRS
* written and informed consent

Exclusion Criteria

* age \<18yrs
* pregnancy
* emergency surgery
* failure to obtain patient consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Cologne

OTHER

Sponsor Role lead

Responsible Party

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Dr. Wolfgang A. Wetsch

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Wolfgang A. Wetsch, M.D.

Role: PRINCIPAL_INVESTIGATOR

Department of Anaesthesiology and Critical Care Medicine, University Hospital of Cologne

Locations

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Department of Anaesthesiology and Critical Care Medicine, University Hospital of Cologne

Cologne, , Germany

Site Status

Countries

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Germany

Other Identifiers

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13-229

Identifier Type: -

Identifier Source: org_study_id