Dissecting the Role of Distal Embolization of Athero-thrombotic Material in Primary PCI: the ThrombOticBurden and mIcrovAscularobStruction (TOBIAS) Study.

NCT ID: NCT01914055

Last Updated: 2013-10-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Brief Summary

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demonstrate that FD-OCT guidance is feasible and possibly results in reduction of frequency-domain Optical Coherence Tomography-defined residual thrombus burden after thrombus-aspiration.

Detailed Description

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Conditions

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Acute Myocardial Infarction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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angio-guided thrombus aspiration

thrombus aspiration guided by angiography

Group Type ACTIVE_COMPARATOR

angio-guided thrombus aspiration (Eliminate catheter, Terumo, Tokyo, Japan)

Intervention Type DEVICE

angio-guided thrombus aspiration with monorail thrombus aspiration catheter (Eliminate, Terumo, Tokyo, Japan)

OCT-guided thrombus aspiration

thrombus aspiration guided by optical coherence tomography

Group Type EXPERIMENTAL

OCT-guided thrombus aspiration (Eliminate catheter, Terumo, Tokyo, Japan)

Intervention Type DEVICE

FD-OCT-guided thrombus aspiration with monorail thrombus aspiration catheter (Eliminate, Terumo, Tokyo, Japan); OCT images will be acquired at the site of culprit coronary artery with a commercially available system (Lunawave System; Fastview catheter/Terumo, Tokio, Japan OR C7 System; LightLab Imaging Inc; C7 Dragonfly catheter/St Jude Medical, Westford, MA)

Interventions

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angio-guided thrombus aspiration (Eliminate catheter, Terumo, Tokyo, Japan)

angio-guided thrombus aspiration with monorail thrombus aspiration catheter (Eliminate, Terumo, Tokyo, Japan)

Intervention Type DEVICE

OCT-guided thrombus aspiration (Eliminate catheter, Terumo, Tokyo, Japan)

FD-OCT-guided thrombus aspiration with monorail thrombus aspiration catheter (Eliminate, Terumo, Tokyo, Japan); OCT images will be acquired at the site of culprit coronary artery with a commercially available system (Lunawave System; Fastview catheter/Terumo, Tokio, Japan OR C7 System; LightLab Imaging Inc; C7 Dragonfly catheter/St Jude Medical, Westford, MA)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* ST elevation myocardial infarction
* Ages Eligible for Study: \>18 years old
* Genders Eligible for Study: Both (female sex with child-bearing potential excluded)

Exclusion Criteria

* occluded (TIMI 0) or sub occluded (TIMI 1) proximal vessel of estimated diameter ≥3mm
* intended use of thrombus aspiration
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ospedale San Donato

OTHER

Sponsor Role lead

Responsible Party

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Leonardo Bolognese, MD

Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cardiovascular Department, Ospedale S.Donato

Arezzo, AR, Italy

Site Status RECRUITING

Countries

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Italy

Facility Contacts

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Leonardo Bolognese

Role: primary

Other Identifiers

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Arezzo009

Identifier Type: -

Identifier Source: org_study_id