Trial Outcomes & Findings for XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS) China Single-Arm Study (NCT NCT01894152)

NCT ID: NCT01894152

Last Updated: 2020-05-26

Results Overview

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality, cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Recruitment status

COMPLETED

Target enrollment

2002 participants

Primary outcome timeframe

≤ 7 days after index procedure (Hospitalization)

Results posted on

2020-05-26

Participant Flow

A total of 2140 patients were registered from 35 centres in China. First patients was enrolled on July 12, 2013 \& enrollment was completed on Sep11, 2014 through the Interactive Voice Response System (IVRS) excluding those without consent and those without stent implants \& duplicate entries. Thus the analysis population includes 2002 participants .

Of the 2140 registered subjects,138 subjects withdrew from the study due to incomplete consent forms, no implanted study stents and repeated entry in voice interactive selection system. Among the final analysis population (n=2002), a total of 151 subjects failed to complete the follow-up period.

Participant milestones

Participant milestones
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Overall Study
STARTED
2002
Overall Study
COMPLETED
1851
Overall Study
NOT COMPLETED
151

Reasons for withdrawal

Reasons for withdrawal
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Overall Study
No DMR and no Stent thrombosis
151

Baseline Characteristics

XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS) China Single-Arm Study

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=2002 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Age, Categorical
<=18 years
0 Participants
n=5 Participants
Age, Categorical
Between 18 and 65 years
1286 Participants
n=5 Participants
Age, Categorical
>=65 years
716 Participants
n=5 Participants
Age, Continuous
60.42 years
STANDARD_DEVIATION 10.72 • n=5 Participants
Sex: Female, Male
Female
501 Participants
n=5 Participants
Sex: Female, Male
Male
1501 Participants
n=5 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=5 Participants
Race (NIH/OMB)
Asian
0 Participants
n=5 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=5 Participants
Race (NIH/OMB)
Black or African American
0 Participants
n=5 Participants
Race (NIH/OMB)
White
0 Participants
n=5 Participants
Race (NIH/OMB)
More than one race
0 Participants
n=5 Participants
Race (NIH/OMB)
Unknown or Not Reported
2002 Participants
n=5 Participants
Region of Enrollment
China
2002 Participants
n=5 Participants

PRIMARY outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality, cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Cardiac Death and All Myocardial Infarction (MI) (Q-wave and Non-Q Wave) Composite Endpoint
7 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality, cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Cardiac Death and All Myocardial Infarction (MI) (Q-wave and Non-Q Wave) Composite Endpoint
114 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

All deaths include Cardiac death, Cardiovascular death and Non-cardiovascular death. Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of All Deaths, Myocardial Infarction, Any Repetitive Revascularization Composite Endpoints
8 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

All deaths include Cardiac death, Cardiovascular death and Non-cardiovascular death. Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of All Deaths, Myocardial Infarction, Any Repetitive Revascularization Composite Endpoints
330 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality, cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) Myocardial Infarction (MI): Patient diagnosed with myocardial infarction, but its relation with target vessel not clear, therefore considered target vessel myocardial infarction. * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Cardiogenic Death, Target Vessel Blood Flow Myocardial Infarction, Target Lesion Revascularization Composite Endpoint
5 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality, cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) Myocardial Infarction (MI): Patient diagnosed with myocardial infarction, but its relation with target vessel not clear, therefore considered target vessel myocardial infarction. * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Cardiogenic Death, Target Vessel Blood Flow Myocardial Infarction, Target Lesion Revascularization Composite Endpoint
120 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

All deaths include Cardiac death, Cardiovascular death and Non-cardiovascular death. Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Composite Rate of All Deaths and Myocardial Infarctions (MI)
8 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

All deaths include Cardiac death, Cardiovascular death and Non-cardiovascular death. Myocardial Infarction (MI): * Q wave MI: Development of new, pathological Q wave on the ECG. * Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Composite Rate of All Deaths and Myocardial Infarctions (MI)
156 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Target Lesion Failure is composite of Cardiac death/ Target Vessel Myocardial Infarction (TV-MI)/ Ischemic-Driven Target Lesion Revascularization (ID-TLR). This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Target Lesion Failure (TLF)
5 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Target Lesion Failure is composite of Cardiac death/ Target Vessel Myocardial Infarction (TV-MI)/ Ischemic-Driven Target Lesion Revascularization (ID-TLR). This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Target Lesion Failure (TLF)
100 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Target Vessel Failure (TVF) is the composite of Cardiac Death, Myocardial infarction (MI) or ischemia-driven Target Vessel Revascularization (ID-TVR). This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Target Vessel Failure (ID-TVF) (Cardiac Death, All Myocardial Infarctions and Ischemia-driven Target Vessel Revascularization)
7 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Target Vessel Failure (TVF) is the composite of Cardiac Death, Myocardial infarction (MI) or ischemia-driven Target Vessel Revascularization (ID-TVR). This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Target Vessel Failure (ID-TVF) (Cardiac Death, All Myocardial Infarctions and Ischemia-driven Target Vessel Revascularization)
180 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality,cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) This study as no primary or secondary endpoints, all endpoints are of equal weight. \- Non-cardiac death is defined as a death not due to cardiac causes (as defined above). This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of All Death (Cardiac, Vascular, and Non-cardiovascular)
3 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Cardiac death is defined as any death in which a cardiac cause cannot be excluded. (This includes but is not limited to acute myocardial infarction, cardiac perforation/pericardial tamponade, arrhythmia or conduction abnormality,cerebrovascular accident within 30 days of the procedure or cerebrovascular accident suspected of being related to the procedure, death due to complication of the procedure, including bleeding, vascular repair, transfusion reaction, or bypass surgery.) This study as no primary or secondary endpoints, all endpoints are of equal weight. \- Non-cardiac death is defined as a death not due to cardiac causes (as defined above). This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of All Death (Cardiac, Vascular, and Non-cardiovascular)
91 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Myocardial Infarction (MI) * Q wave MI Development of new, pathological Q wave on the ECG * Non-Q wave MI Elevation of CK levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All Myocardial Infarction (MI) (Including Q-wave and Non-Q-wave)
6 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Myocardial Infarction (MI) * Q wave MI Development of new, pathological Q wave on the ECG * Non-Q wave MI Elevation of CK levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All Myocardial Infarction (MI) (Including Q-wave and Non-Q-wave)
75 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Target Vessel Revascularization is defined as any repeat percutaneous intervention or surgical bypass of any segment of the target vessel. The target vessel is defined as the entire major coronary vessel proximal and distal to the target lesion which includes upstream and downstream branches and the target lesion itself. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All Target Vessel Revascularization (TVR)
0 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

Target Vessel Revascularization is defined as any repeat percutaneous intervention or surgical bypass of any segment of the target vessel. The target vessel is defined as the entire major coronary vessel proximal and distal to the target lesion which includes upstream and downstream branches and the target lesion itself. This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All Target Vessel Revascularization (TVR)
26 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. All Revascularization includes Coronary artery bypass grafting and Percutaneous coronary intervention

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All Revascularization (Target Lesion, Target Vessel, and Non-target Vessel) (PCI and Coronary Artery Bypass Graft [CABG])
1 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 through 1885 Days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. All Revascularization includes Coronary artery bypass grafting and Percutaneous coronary intervention

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All Revascularization (Target Lesion, Target Vessel, and Non-target Vessel) (PCI and Coronary Artery Bypass Graft [CABG])
223 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1 day

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Scaffold/Stent thrombosis should be reported as a cumulative value at the different time points and with the different separate time points. Time 0 is defined as the time point after the guiding catheter has been removed and the subject left the catheterization lab. Timings: Acute scaffold/stent thrombosis : 0 - 24 hours post stent implantation Subacute scaffold/stent thrombosis: \>24 hours - 30 days post stent implantation Late scaffold/stent thrombosis: 30 days - 1 year post stent implantation Extremely late scaffold/stent thrombosis: \>1 year post stent implantation"

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Acute Stent Thrombosis
0 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: > 1 day to 30 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Scaffold/Stent thrombosis should be reported as a cumulative value at the different time points and with the different separate time points. Time 0 is defined as the time point after the guiding catheter has been removed and the subject left the catheterization lab. Timings: Acute scaffold/stent thrombosis : 0 - 24 hours post stent implantation Subacute scaffold/stent thrombosis: \>24 hours - 30 days post stent implantation Late scaffold/stent thrombosis: 30 days - 1 year post stent implantation Extremely late scaffold/stent thrombosis: \>1 year post stent implantation"

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Sub-acute Stent Thrombosis
2 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 - 30 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Scaffold/Stent thrombosis should be reported as a cumulative value at the different time points and with the different separate time points. Time 0 is defined as the time point after the guiding catheter has been removed and the subject left the catheterization lab. Timings: Acute scaffold/stent thrombosis : 0 - 24 hours post stent implantation Subacute scaffold/stent thrombosis: \>24 hours - 30 days post stent implantation Late scaffold/stent thrombosis: 30 days - 1 year post stent implantation Extremely late scaffold/stent thrombosis: \>1 year post stent implantation"

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Early Stent Thrombosis
2 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 31 to 365 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Scaffold/Stent thrombosis should be reported as a cumulative value at the different time points and with the different separate time points. Time 0 is defined as the time point after the guiding catheter has been removed and the subject left the catheterization lab. Timings: Acute scaffold/stent thrombosis : 0 - 24 hours post stent implantation Subacute scaffold/stent thrombosis: \>24 hours - 30 days post stent implantation Late scaffold/stent thrombosis: 30 days - 1 year post stent implantation Extremely late scaffold/stent thrombosis: \>1 year post stent implantation"

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Late Stent Thrombosis
1 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: > 365 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Scaffold/Stent thrombosis should be reported as a cumulative value at the different time points and with the different separate time points. Time 0 is defined as the time point after the guiding catheter has been removed and the subject left the catheterization lab. Timings: Acute scaffold/stent thrombosis : 0 - 24 hours post stent implantation Subacute scaffold/stent thrombosis: \>24 hours - 30 days post stent implantation Late scaffold/stent thrombosis: 30 days - 1 year post stent implantation Extremely late scaffold/stent thrombosis: \>1 year post stent implantation"

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Very Late Stent Thrombosis
0 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Scaffold/Stent thrombosis should be reported as a cumulative value at the different time points and with the different separate time points. Time 0 is defined as the time point after the guiding catheter has been removed and the subject left the catheterization lab. Timings: Acute scaffold/stent thrombosis : 0 - 24 hours post stent implantation Subacute scaffold/stent thrombosis: \>24 hours - 30 days post stent implantation Late scaffold/stent thrombosis: 30 days - 1 year post stent implantation Extremely late scaffold/stent thrombosis: \>1 year post stent implantation"

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Overall Stent Thrombosis
3 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Myocardial Infarction (MI): Q wave MI: Development of new, pathological Q wave on the ECG. Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Target Vessel ARC MI
2 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Myocardial Infarction (MI): Q wave MI: Development of new, pathological Q wave on the ECG. Non-Q wave MI: Elevation of Creatine kinase (CK) levels to ≥ two times the upper limit of normal (ULN) with elevated CK-MB in the absence of new pathological Q waves.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With Target Vessel ARC MI
23 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. All TVR (TLR and TVR, non-target lesion)

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All TVR (TLR and TVR, Non-target Lesion)
1 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. All TVR (TLR and TVR, non-target lesion)

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All TVR (TLR and TVR, Non-target Lesion)
84 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All TLR
1 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With All TLR
58 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Revascularization includes TLR, TVR, non-target lesion, and non TVR.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With ID-TLR
1 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Revascularization includes TLR, TVR, non-target lesion, and non TVR.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With ID-TLR
37 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Revascularization includes TLR, TVR, non-target lesion, and non TVR.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With ID-TVR, Non-target Lesion
0 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Revascularization includes TLR, TVR, non-target lesion, and non TVR.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With ID-TVR, Non-target Lesion
22 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: ≤ 7 days after index procedure (Hospitalization)

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Revascularization includes TLR, TVR, non-target lesion, and non TVR.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With ID-TVR (TLR and TVR, Non-target Lesion)
1 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 0 to 1885 days

Population: Full Analysis Set (FAS). Full Analysis Set includes all patients who had implanted XIENCE PRIME EECSS stent in the start-up procedures. The analysis population includes patients with DMR composite event (deaths, myocardial infarctions, revascularization cases) or stent thrombosis or complete follow-up at given point in time.

This study has no primary or secondary endpoints, all endpoints are of equal weight. Revascularization includes TLR, TVR, non-target lesion, and non TVR.

Outcome measures

Outcome measures
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=1851 Participants
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Number of Participants With ID-TVR (TLR and TVR, Non-target Lesion)
59 Participants

Adverse Events

XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)

Serious events: 1105 serious events
Other events: 103 other events
Deaths: 91 deaths

Serious adverse events

Serious adverse events
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=2002 participants at risk
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
General disorders
WEAK
0.05%
1/2002 • 5 years
Hepatobiliary disorders
ACUTE PANCREATITIS
0.05%
1/2002 • 5 years
Hepatobiliary disorders
CONSTRICTIVE PERICARDITIS
0.05%
1/2002 • 5 years
Hepatobiliary disorders
HEMORRHAGE OF LIVER
0.05%
1/2002 • 5 years
Hepatobiliary disorders
LIVER FAILURE
0.10%
2/2002 • 5 years
Injury, poisoning and procedural complications
NON-TARGET VESSEL PCI
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
PCI POSTOPERATIVE UPPER GASTROINTESTINAL BLEEDING
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
POSTOPERATIVE PCI
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
REVASCULARIZATION
0.35%
7/2002 • 5 years
Injury, poisoning and procedural complications
REVASCULARIZATION OF LCX
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
REVIEW AFTER PCI
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
STENT THROMBOSIS
0.15%
3/2002 • 5 years
Injury, poisoning and procedural complications
STENT RESTENOSIS
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
TOXIC MULTIPLE NEUROPATHY CAUSED BY DRUG
0.05%
1/2002 • 5 years
Investigations
CORONARY HEART DISEASE AND POST- PCI
0.15%
3/2002 • 5 years
Investigations
CORONARY HEART DISEASE REEXAMINATION
0.10%
2/2002 • 5 years
Investigations
CORONORY ANGIOGRAPHY(NOS)
0.05%
1/2002 • 5 years
Metabolism and nutrition disorders
DIABETES MELLITUS
0.15%
3/2002 • 5 years
Metabolism and nutrition disorders
DIABETIC KETOACIDOSIS CAUSE THE DEATH
0.05%
1/2002 • 5 years
Metabolism and nutrition disorders
HYPERGLYCEMIA
0.10%
2/2002 • 5 years
Metabolism and nutrition disorders
HYPERTHYREOSIS
0.05%
1/2002 • 5 years
Musculoskeletal and connective tissue disorders
GOUT
0.05%
1/2002 • 5 years
Musculoskeletal and connective tissue disorders
PATHOLOGICAL FRACTURE
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
BREAST CANCER
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
CANCER
0.10%
2/2002 • 5 years
Blood and lymphatic system disorders
ANEMIA
0.05%
1/2002 • 5 years
Blood and lymphatic system disorders
BLOOD DISEASE
0.05%
1/2002 • 5 years
Blood and lymphatic system disorders
MASSIVE ABDOMINAL HEMORRHAGE
0.05%
1/2002 • 5 years
Cardiac disorders
CHEST PAIN-CARDIAC
0.80%
16/2002 • 5 years
Cardiac disorders
CHEST PAIN AND CHEST TIGHTNESS (CHD)
0.20%
4/2002 • 5 years
Cardiac disorders
ACUTE CORONARY SYNDROME
0.35%
7/2002 • 5 years
Cardiac disorders
ACUTE HEART FAILURE
0.15%
3/2002 • 5 years
Cardiac disorders
ACUTE NON - ST SEGMENT ELEVATION MYOCARDIAL INFARCTION
0.30%
6/2002 • 5 years
Cardiac disorders
ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
0.05%
1/2002 • 5 years
Cardiac disorders
ANGINA PECTORIS
2.4%
49/2002 • 5 years
Cardiac disorders
UNSTABLE ANGINA PECTORIS
8.4%
169/2002 • 5 years
Cardiac disorders
CHEST TIGHTNESS-CARDIAC
0.45%
9/2002 • 5 years
Cardiac disorders
ARRHYTHMIA
0.50%
10/2002 • 5 years
Cardiac disorders
ARRHYTHMIA PERMANENT PACEMAKER IMPLANTATION
0.05%
1/2002 • 5 years
Cardiac disorders
ARRHYTHMIA, ATRIAL FIBRILLATION
0.05%
1/2002 • 5 years
Cardiac disorders
ATRIAL FIBRILLATION
0.65%
13/2002 • 5 years
Cardiac disorders
ATRIAL FLUTTER
0.10%
2/2002 • 5 years
Cardiac disorders
ATRIAL PREMATURE BEAT
0.05%
1/2002 • 5 years
Cardiac disorders
VENTRICULAR PREMATURE BEAT
0.15%
3/2002 • 5 years
Cardiac disorders
CORONARY HEART DISEASE
11.8%
236/2002 • 5 years
Cardiac disorders
CARDIAC ARREST
0.05%
1/2002 • 5 years
Cardiac disorders
CARDIAC DYSFUNCTION
0.05%
1/2002 • 5 years
Cardiac disorders
CARDIAC ENLARGEMENT
0.05%
1/2002 • 5 years
Cardiac disorders
CARDIAC INSUFFICIENCY
0.05%
1/2002 • 5 years
Cardiac disorders
CARDIAC RESPIRATORY ARREST
0.05%
1/2002 • 5 years
Cardiac disorders
CARDIAC TAMPONADE
0.05%
1/2002 • 5 years
Cardiac disorders
CHRONIC CORONARY INSUFFICIENCY
0.05%
1/2002 • 5 years
Cardiac disorders
HEART FAILURE
1.2%
24/2002 • 5 years
Cardiac disorders
CONGENITAL ATRIAL SEPTAL DEFECT
0.05%
1/2002 • 5 years
Cardiac disorders
CORONARY ATHEROSCLEROTIC CARDIOPATHY
0.65%
13/2002 • 5 years
Cardiac disorders
CORONARY HEART DISEASE DEATH
0.10%
2/2002 • 5 years
Cardiac disorders
EXTRASYSTOLE
0.05%
1/2002 • 5 years
Cardiac disorders
HEART PALPITATIONS
0.05%
1/2002 • 5 years
Cardiac disorders
HYDROPERICARDIUM
0.10%
2/2002 • 5 years
Cardiac disorders
ISCHEMIC CARDIOMYOPATHY
0.15%
3/2002 • 5 years
Cardiac disorders
LETHAL MYOCARDIAL INFARCTION
0.10%
2/2002 • 5 years
Cardiac disorders
MYOCARDIAL INFARCTION
3.3%
66/2002 • 5 years
Cardiac disorders
OLD MYOCARDIAL INFARCTION
0.35%
7/2002 • 5 years
Cardiac disorders
MYOCARDIAL BRIDGE
0.05%
1/2002 • 5 years
Cardiac disorders
NON-TARGET VESSEL REVASCULARIZATION
0.25%
5/2002 • 5 years
Cardiac disorders
PRECORDIAL DISTRESS
0.10%
2/2002 • 5 years
Cardiac disorders
SICK SINUS SYNDROME
0.05%
1/2002 • 5 years
Cardiac disorders
TACHYCARDIA-BRADYCARDIA SYNDROME
0.05%
1/2002 • 5 years
Cardiac disorders
TARGET LESION REVASCULARIZATION
0.05%
1/2002 • 5 years
Cardiac disorders
TRANSIENT ISCHEMIC ATTACK
0.05%
1/2002 • 5 years
Cardiac disorders
TVR or TLR
1.0%
21/2002 • 5 years
Cardiac disorders
VENTRICULAR FIBRILLATION
0.10%
2/2002 • 5 years
Cardiac disorders
CHRONIC HEART FAILURE
0.05%
1/2002 • 5 years
Eye disorders
BINOCULAR CATARACT
0.05%
1/2002 • 5 years
Eye disorders
LEFT EYE SENILE CATARACT
0.05%
1/2002 • 5 years
Eye disorders
RIGHT EYE CATARACT
0.05%
1/2002 • 5 years
Eye disorders
TRACTIONAL RETINAL DETACHMENT
0.05%
1/2002 • 5 years
Eye disorders
RIGHT EYE SENILE CATARACT (MATURE PERIOD)
0.05%
1/2002 • 5 years
Gastrointestinal disorders
UPPER GASTROINTESTINAL HEMORRHAGE
0.40%
8/2002 • 5 years
Gastrointestinal disorders
GASTROINTESTINAL HEMORRHAGE
0.95%
19/2002 • 5 years
Gastrointestinal disorders
BLACK STOOL
0.05%
1/2002 • 5 years
Gastrointestinal disorders
CHRONIC GASTRITIS
0.10%
2/2002 • 5 years
Gastrointestinal disorders
CHRONIC NON-ATROPHIC GASTRITIS WITH BILE REFLUX
0.05%
1/2002 • 5 years
Gastrointestinal disorders
CHRONIC NON-ATROPHIC GASTRITIS WITH EROSION
0.05%
1/2002 • 5 years
Gastrointestinal disorders
GASTRIC ULCER
0.05%
1/2002 • 5 years
Gastrointestinal disorders
GASTRIC ULCER WITH BLEEDING
0.15%
3/2002 • 5 years
Gastrointestinal disorders
LEFT INGUINAL HERNIA
0.05%
1/2002 • 5 years
General disorders
CHEST PAIN
2.9%
58/2002 • 5 years
General disorders
CHEST PAIN AND CHEST TIGHTNESS
0.40%
8/2002 • 5 years
General disorders
CHEST TIGHTNESS
3.1%
63/2002 • 5 years
General disorders
BREASTBONE HIND TIGHTENING FEELING
0.05%
1/2002 • 5 years
General disorders
CHEST BLEEDING
0.05%
1/2002 • 5 years
General disorders
CHEST DISCOMFORT
0.15%
3/2002 • 5 years
General disorders
CHEST DISTRESS
0.35%
7/2002 • 5 years
General disorders
CHEST HEART PALPITATIONS
0.05%
1/2002 • 5 years
General disorders
DEATH
2.1%
42/2002 • 5 years
General disorders
DISCOMFORT IN THE ANTERIOR REGION OF THE HEART
0.05%
1/2002 • 5 years
General disorders
DIZZY
0.20%
4/2002 • 5 years
General disorders
EDEMA
0.05%
1/2002 • 5 years
General disorders
INTERMITTENT CHEST DISCOMFORT
0.05%
1/2002 • 5 years
General disorders
SYNCOPE
0.25%
5/2002 • 5 years
General disorders
MULTI-ORGAN FAILURE
0.05%
1/2002 • 5 years
General disorders
NECK DISCOMFORT
0.05%
1/2002 • 5 years
General disorders
PALPITATION
0.45%
9/2002 • 5 years
General disorders
THE AREA BEFORE THE HEART PALPITATIONS, SHORTNESS
0.05%
1/2002 • 5 years
General disorders
THE AREA BEFORE THE HEART TIGHTNESS
0.05%
1/2002 • 5 years
General disorders
THE LIMBS SWELLING
0.05%
1/2002 • 5 years
General disorders
TO TREAT OTHER VASCULAR LESIONS
0.05%
1/2002 • 5 years
General disorders
VERTIGO SYNDROME
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
CANCER OF THE STOMACH
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
CANCER METASTASIS
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
COLORECTAL CANCER
0.10%
2/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
DESCENDING COLON TUMOR
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
ESOPHAGEAL MALIGNANT TUMOR
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
LIVER CANCER
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
LIVER CYST
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
LUNG CANCER
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
LYMPHOMA
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
PROSTATIC HYPERPLASIA
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
PULMONARY HEMANGIOMA
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
SACRAL TUMOR
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
SMALL CELL LUNG CANCER
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
STOMACH CANCER
0.05%
1/2002 • 5 years
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
BILATERAL OVARIAN CYSTS
0.05%
1/2002 • 5 years
Nervous system disorders
ACUTE BRAINSTEM INFARCTION
0.05%
1/2002 • 5 years
Nervous system disorders
ANGIONEUROEDEMA
0.05%
1/2002 • 5 years
Nervous system disorders
CEREBRAL INSUFFICIENCY
0.05%
1/2002 • 5 years
Nervous system disorders
CERVICAL HEADACHE
0.05%
1/2002 • 5 years
Nervous system disorders
DEATH(CEREBRAL INFARCTION AND CEREBRAL HERNIA)
0.05%
1/2002 • 5 years
Nervous system disorders
GUILLAIN-BARRE SYNDROME
0.05%
1/2002 • 5 years
Nervous system disorders
ISCHEMIC CEREBROVASCULAR DISEASE
0.05%
1/2002 • 5 years
Nervous system disorders
LACUNAR INFARCTION
0.10%
2/2002 • 5 years
Nervous system disorders
LEFT TEMPORAL LOBE BRAIN CONTUSION
0.05%
1/2002 • 5 years
Nervous system disorders
LUMBAR SPINAL STENOSIS
0.05%
1/2002 • 5 years
Nervous system disorders
STROKE
0.05%
1/2002 • 5 years
Nervous system disorders
SUBARACHNOID HEMORRHAGE
0.05%
1/2002 • 5 years
Renal and urinary disorders
BILATERAL URETERAL CALCULI
0.10%
2/2002 • 5 years
Renal and urinary disorders
RENAL FAILURE
0.10%
2/2002 • 5 years
Renal and urinary disorders
RIGHT HYDRONEPHROSIS WITH URETERAL STRICTURE
0.05%
1/2002 • 5 years
Reproductive system and breast disorders
ENDOMETRIAL LESIONS
0.05%
1/2002 • 5 years
Reproductive system and breast disorders
OOPHORITIC CYST
0.05%
1/2002 • 5 years
Reproductive system and breast disorders
VAGINAL BLEEDING
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
BRONCHIAL ASTHMA
0.10%
2/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
SHORTNESS OF BREATH
0.25%
5/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
ANHELATION
0.10%
2/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
CHEST TIGHTNESS AND SHORTNESS OF BREATH
0.10%
2/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
COPD
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
LEFT PLEURAL EFFUSION
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
LUNG INFECTION
0.10%
2/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
MAXILLARY SINUSITIS
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
MIXED LUNG VENTILATION DYSFUNCTION
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
PNEUMONIA
0.25%
5/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
PULMONARY FIBROSIS
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
PULMONARY INFECTION
0.15%
3/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
PULMONARY MULTILOBE PNEUMONIA
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
RESPIRATORY FAILURE
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
SEVERE PNEUMONIA AND RESPIRATORY FAILURE
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
TYPE I RESPIRATORY FAILURE
0.05%
1/2002 • 5 years
Skin and subcutaneous tissue disorders
LACERATION OF SCALP SOFT TISSUE
0.05%
1/2002 • 5 years
Vascular disorders
ABDOMINAL ANEURYSM
0.05%
1/2002 • 5 years
Vascular disorders
ABNORMAL VESSELS IN CORONARY ARTERIES
0.05%
1/2002 • 5 years
Vascular disorders
ARTERIOSCLEROSIS OBLITERANS OF LOWER EXTREMITY
0.05%
1/2002 • 5 years
Vascular disorders
ATHEROSCLEROSIS
0.05%
1/2002 • 5 years
Vascular disorders
CAROTID ARTERY OCCLUSION
0.05%
1/2002 • 5 years
Vascular disorders
CEREBRAL HEMORRHAGE
0.35%
7/2002 • 5 years
Vascular disorders
CEREBRAL INFARCTION
0.60%
12/2002 • 5 years
Vascular disorders
HYPERTENSION
0.35%
7/2002 • 5 years
Vascular disorders
INSUFFICIENT BLOOD SUPPLY TO THE CEREBRAL ARTERY
0.05%
1/2002 • 5 years
Vascular disorders
POSTERIOR CIRCULATION ISCHEMIA
0.25%
5/2002 • 5 years
Vascular disorders
PULMONARY EMBOLISM
0.05%
1/2002 • 5 years
Vascular disorders
SEQUELAE OF CEREBRAL INFARCTION
0.10%
2/2002 • 5 years
Vascular disorders
VASCULAR STENOSIS
0.05%
1/2002 • 5 years
Vascular disorders
VENTRICULAR ANEURYSM
0.10%
2/2002 • 5 years

Other adverse events

Other adverse events
Measure
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
n=2002 participants at risk
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS): Subjects receiving XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
Blood and lymphatic system disorders
HEMORRHOIDAL BLEEDING
0.10%
2/2002 • 5 years
Cardiac disorders
ANGINA PECTORIS
0.50%
10/2002 • 5 years
Cardiac disorders
AURICULAR FIBRILLATION
0.05%
1/2002 • 5 years
Cardiac disorders
CHEST PAIN - CARDIAC
0.05%
1/2002 • 5 years
Cardiac disorders
CORONARY ARTERY DISEASE
0.15%
3/2002 • 5 years
Cardiac disorders
HEART FAILURE
0.10%
2/2002 • 5 years
Cardiac disorders
MI
0.10%
2/2002 • 5 years
Cardiac disorders
PREMATURE BEAT
0.10%
2/2002 • 5 years
Cardiac disorders
REPERFUSION ARRHYTHMIA
0.10%
2/2002 • 5 years
Cardiac disorders
RESTING ANGINA
0.05%
1/2002 • 5 years
Cardiac disorders
UNSTABLE ANGINA
0.50%
10/2002 • 5 years
Eye disorders
BLEEDING IN EYES
0.15%
3/2002 • 5 years
Gastrointestinal disorders
DEFECATE HAEMORRHAGE
0.10%
2/2002 • 5 years
Gastrointestinal disorders
GASTRIC COLIC
0.05%
1/2002 • 5 years
Gastrointestinal disorders
GASTROINTESTINAL BLEEDING
0.40%
8/2002 • 5 years
Gastrointestinal disorders
UPSET STOMACH
0.10%
2/2002 • 5 years
General disorders
BLEEDING
0.05%
1/2002 • 5 years
General disorders
BLEEDING GUMS
0.30%
6/2002 • 5 years
General disorders
CHEST PAIN
0.25%
5/2002 • 5 years
General disorders
CHEST TIGHTEN AND CARDIOPALMUS
0.05%
1/2002 • 5 years
General disorders
CHEST TIGHTNESS
0.20%
4/2002 • 5 years
General disorders
DIZZY
0.05%
1/2002 • 5 years
General disorders
FEEL SUFFOCATED
0.05%
1/2002 • 5 years
General disorders
HEMORRHAGIC SPOT
0.05%
1/2002 • 5 years
General disorders
PALPITATION
0.15%
3/2002 • 5 years
General disorders
SHORT OF BREATH
0.05%
1/2002 • 5 years
General disorders
STOMACHACHE
0.05%
1/2002 • 5 years
General disorders
SYNCOPE
0.05%
1/2002 • 5 years
General disorders
TOOTHACHE
0.05%
1/2002 • 5 years
General disorders
0.05%
1/2002 • 5 years
Injury, poisoning and procedural complications
OM1 SEGMENT OCCLUDED
0.05%
1/2002 • 5 years
Investigations
CNI IS HIGHER THAN NORMAL VALUE
0.05%
1/2002 • 5 years
Investigations
ELEVATED TROPOLIN T
0.15%
3/2002 • 5 years
Investigations
ELEVATED TROPONIN I
0.30%
6/2002 • 5 years
Nervous system disorders
LACUNAR INFARCTION
0.05%
1/2002 • 5 years
Nervous system disorders
VAGAL REFLEX
0.05%
1/2002 • 5 years
Nervous system disorders
VERTEBRAL STENOSIS
0.05%
1/2002 • 5 years
Respiratory, thoracic and mediastinal disorders
NOSE BLEEDING
0.10%
2/2002 • 5 years
Skin and subcutaneous tissue disorders
SUBCUTANEOUS HEMORRHAGE
0.25%
5/2002 • 5 years
Skin and subcutaneous tissue disorders
PRURITUS
0.05%
1/2002 • 5 years
Skin and subcutaneous tissue disorders
SKIN ALLERGY
0.05%
1/2002 • 5 years

Additional Information

Roy Leong

Abbott Vascular

Phone: +65 (6277) 3202

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place