Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

NCT ID: NCT01892813

Last Updated: 2017-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

411 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2018-01-31

Brief Summary

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The project is designed to examine the effectiveness of strategies to increase access to treatment for tobacco use and dependence among rural Veteran smokers. In addition, it will examine whether tailored treatment that is designed to address common comorbid conditions that are related to cigarette smoking enhances success with quitting relative to enhanced standard of care. The investigators hypothesize that participants assigned to the tailored tobacco cessation intervention will report greater cessation rates at six months. The investigators also anticipate more favorable outcomes on measures of depressive symptoms, alcohol use, and body weight.

Detailed Description

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Conditions

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Nicotine Dependence Tobacco Use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Tailored intervention

Participants will receive a combined behavioral and pharmacological intervention. The behavioral component will consist of a six-session cognitive behavioral telephone intervention combined with supplemental treatment modules to address common issues (symptoms of depression, weight gain, risky alcohol use) associated with cigarette smoking based on eligibility and preference.

Group Type EXPERIMENTAL

Nicotine replacement therapy - Transdermal nicotine patch

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Nicotine replacement therapy - Nicotine gum

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Nicotine replacement therapy - Nicotine lozenge

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Bupropion

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Varenicline

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Combination pharmacotherapy - Transdermal nicotine patch + bupropion

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Tailored behavioral intervention

Intervention Type BEHAVIORAL

Participants will receive a standard six session cognitive behavioral intervention for smoking cessation combined with supplemental treatment modules based on individual need and preference.

Alcohol use risk reduction

Intervention Type BEHAVIORAL

Participants engaging in risky alcohol use may receive this six-session telephone-based behavioral intervention for reducing alcohol use.

Behavioral activation for depressive symptoms

Intervention Type BEHAVIORAL

Participants with elevated depressive symptoms may receive this six-session telephone-based behavioral activation intervention.

Behavioral management of postcessation weight gain

Intervention Type BEHAVIORAL

Participants with concerns about gaining weight after quitting smoking may receive this six-session telephone-based behavioral self-management intervention designed to help attenuate post-cessation weight gain.

Enhanced standard of care

Participants assigned to the enhanced standard of care condition will receive referral to their state tobacco quitline along with pharmacotherapy to assist with smoking cessation.

Group Type ACTIVE_COMPARATOR

Nicotine replacement therapy - Transdermal nicotine patch

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Nicotine replacement therapy - Nicotine gum

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Nicotine replacement therapy - Nicotine lozenge

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Bupropion

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Varenicline

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Combination pharmacotherapy - Transdermal nicotine patch + bupropion

Intervention Type DRUG

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Tobacco quitline referral

Intervention Type BEHAVIORAL

Participants assigned to this condition will receive a referral to their state tobacco quitline. The specific behavioral treatment that is provided will differ slightly depending upon the services available through the participant's state of residence.

Interventions

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Nicotine replacement therapy - Transdermal nicotine patch

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Nicotine replacement therapy - Nicotine gum

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Nicotine replacement therapy - Nicotine lozenge

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Bupropion

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Varenicline

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Combination pharmacotherapy - Transdermal nicotine patch + bupropion

Medication selection will be determined based on individual participant preferences, medical history, and contraindications.

Intervention Type DRUG

Tobacco quitline referral

Participants assigned to this condition will receive a referral to their state tobacco quitline. The specific behavioral treatment that is provided will differ slightly depending upon the services available through the participant's state of residence.

Intervention Type BEHAVIORAL

Tailored behavioral intervention

Participants will receive a standard six session cognitive behavioral intervention for smoking cessation combined with supplemental treatment modules based on individual need and preference.

Intervention Type BEHAVIORAL

Alcohol use risk reduction

Participants engaging in risky alcohol use may receive this six-session telephone-based behavioral intervention for reducing alcohol use.

Intervention Type BEHAVIORAL

Behavioral activation for depressive symptoms

Participants with elevated depressive symptoms may receive this six-session telephone-based behavioral activation intervention.

Intervention Type BEHAVIORAL

Behavioral management of postcessation weight gain

Participants with concerns about gaining weight after quitting smoking may receive this six-session telephone-based behavioral self-management intervention designed to help attenuate post-cessation weight gain.

Intervention Type BEHAVIORAL

Other Intervention Names

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Nicotine polacrilix Nicotine polacrilix Zyban Chantix Harm reduction Weight management

Eligibility Criteria

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Inclusion Criteria

* Veteran status
* 18 + years of age
* Smoke cigarettes on at least a daily basis
* Receive primary care from the Iowa City VA Health Care System or an affiliated Community-based Outpatient Clinic (CBOC)
* Live in a non-metropolitan area (based on Rural-Urban Commuting Area Codes (RUCA) codes)
* Be willing to make an attempt to quit smoking in the next 30 days
* Be capable of providing informed consent
* Have access to a telephone (land line or cell phone)
* Have a stable residence

Exclusion Criteria

* Planning to move within the next 12 months
* Presence of a terminal illness
* Pregnancy
* Unstable psychiatric disorder (e.g., acute psychosis)
* Currently pregnant
* Incarcerated
* Institutionalized
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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VA Office of Research and Development

FED

Sponsor Role collaborator

Mark Vander Weg

OTHER

Sponsor Role lead

Responsible Party

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Mark Vander Weg

Associate Professor of Internal Medicine

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Mark W. Vander Weg, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

VRHRC-CR

Locations

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Iowa City VA Healthcare System

Iowa City, Iowa, United States

Site Status

Countries

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United States

References

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Livingstone-Banks J, Fanshawe TR, Thomas KH, Theodoulou A, Hajizadeh A, Hartman L, Lindson N. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 May 5;5(5):CD006103. doi: 10.1002/14651858.CD006103.pub8.

Reference Type DERIVED
PMID: 37142273 (View on PubMed)

Other Identifiers

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201305740

Identifier Type: -

Identifier Source: org_study_id

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