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Histologic Response to UVA and UVB Exposure During the Use of Sunscreen

NCT ID: NCT01892150

Last Updated: 2014-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

2 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2013-07-31

Brief Summary

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Anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Detailed Description

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Premature aging can be prevented by using sunscreen. Currently, anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Conditions

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Solar Elastosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Sunscreen

Apply sunscreen before and after UVA and UVB irradiation

Group Type EXPERIMENTAL

Sunscreen

Intervention Type OTHER

Apply sunscreen before and after UVA and UVB irradiation

Interventions

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Sunscreen

Apply sunscreen before and after UVA and UVB irradiation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* subjects aged 35-65 years who were scheduled for abdominoplasty
* the excised area should be larger than 18x10 cm2
* no skin diseases or lesions on the excised area
* no topical treatment on excised area more than 1 month prior to this study

Exclusion Criteria

* pregnancy
* lactation
* have tattoo or striae distensae on abdomen
Minimum Eligible Age

35 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rungsima Wanitphakdeedecha, MD, MA, MSc

Role: PRINCIPAL_INVESTIGATOR

Mahidol University

Locations

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Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, , Thailand

Site Status

Countries

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Thailand

References

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Lavker RM, Gerberick GF, Veres D, Irwin CJ, Kaidbey KH. Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. J Am Acad Dermatol. 1995 Jan;32(1):53-62. doi: 10.1016/0190-9622(95)90184-1.

Reference Type RESULT
PMID: 7822517 (View on PubMed)

Other Identifiers

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721/2555(EC2)

Identifier Type: OTHER

Identifier Source: secondary_id

Siriraj-Eucerin02

Identifier Type: -

Identifier Source: org_study_id