Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

NCT ID: NCT01888991

Last Updated: 2013-06-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2012-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Food Intake Regulation Substrate Oxidation

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Glucose Exercise Metabolic flexibility Substrate Oxidation Food intake

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

water with resting condition

Group Type NO_INTERVENTION

No interventions assigned to this group

glucose with resting condition

Group Type EXPERIMENTAL

Glucose Preload and Exercise Intervention

Intervention Type OTHER

A glucose preload and exercise were administered to examine the modulate substrate oxidation

water with exercise condition

Group Type EXPERIMENTAL

Glucose Preload and Exercise Intervention

Intervention Type OTHER

A glucose preload and exercise were administered to examine the modulate substrate oxidation

glucose with exercise condition

Group Type EXPERIMENTAL

Glucose Preload and Exercise Intervention

Intervention Type OTHER

A glucose preload and exercise were administered to examine the modulate substrate oxidation

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Glucose Preload and Exercise Intervention

A glucose preload and exercise were administered to examine the modulate substrate oxidation

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Born at full term
* Men Age:20-29 years/BMI: 20-25
* Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion Criteria

* Smokers
* Dieters
* Individuals with lactose intolerance, allergies to milk and dairy products
* Individuals with gastrointestinal problems
* Individuals with diabetes or other metabolic diseases
* Individuals scoring ≥ 11 on an Eating Habit Questionnaire
Minimum Eligible Age

9 Years

Maximum Eligible Age

29 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

Sponsor Role collaborator

University of Toronto

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

G. Harvey Anderson

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Harvey Anderson, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Toronto

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Department of Nutritional Sciences, University of Toronto

Toronto, Ontario, Canada

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Canada

References

Explore related publications, articles, or registry entries linked to this study.

Tamam S, Bellissimo N, Patel BP, Thomas SG, Anderson GH. Overweight and obese boys reduce food intake in response to a glucose drink but fail to increase intake in response to exercise of short duration. Appl Physiol Nutr Metab. 2012 Jun;37(3):520-9. doi: 10.1139/h2012-038. Epub 2012 Apr 25.

Reference Type BACKGROUND
PMID: 22530879 (View on PubMed)

Bellissimo N, Thomas SG, Goode RC, Anderson GH. Effect of short-duration physical activity and ventilation threshold on subjective appetite and short-term energy intake in boys. Appetite. 2007 Nov;49(3):644-51. doi: 10.1016/j.appet.2007.04.004. Epub 2007 Apr 22.

Reference Type BACKGROUND
PMID: 17537539 (View on PubMed)

Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. Int J Behav Nutr Phys Act. 2009 Oct 9;6:66. doi: 10.1186/1479-5868-6-66.

Reference Type BACKGROUND
PMID: 19818131 (View on PubMed)

Hunschede S, El Khoury D, Antoine-Jonville S, Smith C, Thomas S, Anderson GH. Acute changes in substrate oxidation do not affect short-term food intake in healthy boys and men. Appl Physiol Nutr Metab. 2015 Feb;40(2):168-77. doi: 10.1139/apnm-2014-0188. Epub 2014 Oct 22.

Reference Type DERIVED
PMID: 25603432 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CIHR MOP-111250

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

CIHR kids_26570

Identifier Type: -

Identifier Source: org_study_id