AR08 for Treatment of ADHD in Children

NCT ID: NCT01876719

Last Updated: 2015-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-06-30

Study Completion Date

2015-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a multicenter, multiple dose, randomized, double-blind, placebo-controlled, forced titration study. Patients will be randomized to 1 of 4 treatment groups in a 1:1:1:1 ratio. One-hundred twenty (120) patients are planned to be randomized. Each patient will receive AR08 (0.5, 1, or 2 mg per day) or matching placebo for seven (7) weeks.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

ADHD

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

ADHD AR08 adrenergic receptor agonists randomized, placebo-controlled clinical trial

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

0.5 mg AR08

0.5 mg AR08, QD for 7 weeks

Group Type EXPERIMENTAL

AR08

Intervention Type DRUG

1.0 mg AR08

1.0 mg AR08, QD for 7 weeks

Group Type EXPERIMENTAL

AR08

Intervention Type DRUG

2.0 mg AR08

2.0 mg AR08, QD for 7 weeks

Group Type EXPERIMENTAL

AR08

Intervention Type DRUG

Placebo

Placebo, QD for 7 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

AR08

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Meets DSM-IV-TR criteria for a primary diagnosis of ADHD based on structured clinical interview, MINI-KID, as assessed by the Investigator
2. Minimum score of 28 on the ADHD-RS-IV at Baseline
3. Male or female ages 6 - 17 years, inclusive, at the time of Screening
4. Weighs ≥21 kg (46 pounds).
5. Is functioning at age appropriate levels intellectually, as deemed by the Investigator.

Exclusion Criteria

1. Has a comorbid psychiatric diagnosis (comorbid psychiatric diagnosis will be established by the MINI-KID interview).
2. Has a positive response to either question 4 or 5 of the Baseline /Screening version of the pediatric Columbia Suicide Severity Rating Scale (C-SSRS)
3. History of daily usage (at least 28 days/month) of either anti-hypertensive or prophylactic anti-migraine medications prior to Screening
4. Current usage of medications known to cause QTc prolongation or ADHD medications.
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Arbor Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Laurence Downey, MD

Role: STUDY_DIRECTOR

Arbor Pharmaceuticals

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Florida Clinical Research Center, LLC

Brandenton, Florida, United States

Site Status

Clinical Neuroscience Solutions, Inc.

Jacksonville, Florida, United States

Site Status

Segal Institute for Clinical Research

North Miami, Florida, United States

Site Status

CNS Healthcare

Orlando, Florida, United States

Site Status

Miami Research Associates

South Miami, Florida, United States

Site Status

Janus Center for Psychiatric Research

West Palm Beach, Florida, United States

Site Status

Atlanta Center for Medical Research

Atlanta, Georgia, United States

Site Status

Midwest Research Group at St. Charles Psychiatric Associates

Saint Charles, Missouri, United States

Site Status

Center for Psychiatry and Behavioral Medicine, Inc.

Las Vegas, Nevada, United States

Site Status

CNS Healthcare

Memphis, Tennessee, United States

Site Status

Bayou City Research Ltd.

Houston, Texas, United States

Site Status

Houston Clinical Trials

Houston, Texas, United States

Site Status

Neuroscience Associates

Herndon, Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

AR08.001

Identifier Type: -

Identifier Source: org_study_id