An Observational Study of YONDELIS®+PLD for the Treatment of Patients With Platinum-sensitive Relapse of Ovarian Cancer

NCT ID: NCT01869400

Last Updated: 2018-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

83 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-30

Study Completion Date

2017-02-28

Brief Summary

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Clinical trials are, due to the inclusion and exclusion criteria, accomplished with defined patient groups, which are not representative for the whole patient population.

Especially elderly patients and patients with co-morbidities are underrepresented in clinical trials.

This non-interventional study will examine the efficiency and toxicity of the Yondelis® + PLD combination therapy in a general patient population to evaluate if the data collected in the clinical trials can be assigned to a general patient population.

Detailed Description

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Yondelis® (trabectedin) was approved (in combination with PLD) in the European community in December 2009 for the treatment of platinum-sensitive ovarian cancer relapse. Based on the outcomes of study OVA-301, this non-interventional study will investigate the role of a platinum-free treatment regimen in patients with progressive ovarian cancer relapsing \> 6 months after completing previous platinum-based chemotherapy. In particular, this study aims at collecting the "real-life" data with regard to the response and the influence of the mentioned therapy on the "tumor related events", to objectify the value of palliative care.

Conditions

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Recurrent Ovarian Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Yondelis-Pegylated liposomal Doxorubicin

30 mg/m² PLD i.v. followed by 1.1 mg/m² Yondelis® i.v. 3 h, q3weeks

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Women age \>18, no upper limit
* Patients with relapsed platinum-sensitive ovarian cancer
* Before inclusion in the NIS written informed consent must be given

Exclusion Criteria

* According to summary of product characteristics
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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PharmaMar, Spain

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ingo Runnebaum, Prof. Dr.

Role: STUDY_CHAIR

Klinikum der Friedrich-Schiller-Universität Jena, Klinik für Frauenheilkunde, Bachstr. 18, D-07743 Jena

Locations

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Praxis und Tagesklinik für gynäkologische Onkologie

Ebersberg, Bavaria, Germany

Site Status

Diakoniekrankenhaus, Gynäkologie und Geburtshilfe

Rotenburg (Wümme), Lower Saxony, Germany

Site Status

Countries

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Germany

Other Identifiers

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OvaYond

Identifier Type: -

Identifier Source: org_study_id

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