Functional and Clinical Impact of CYP3A Genetic Polymorphisms on Statin Therapy

NCT ID: NCT01867203

Last Updated: 2021-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2017-08-01

Study Completion Date

2019-09-01

Brief Summary

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Patients needing lipid lowering therapy will be recruited before initiation of the treatment. For each patient, total and LDL cholesterol levels before start of therapy will be measured. One, three and six months after his/her first visit, when steady-state will be reached, for each included patient, the cholesterol levels will be re-assessed in order to evaluate the response to statin therapy calculated as the amplitude of cholesterol reduction. The aim is to assess the association between patient's genotype and the response to statin therapy.

Detailed Description

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Conditions

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Patients With High Cholesterol Levels Needing a Lipid-lowering Therapy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Statin users

Genotyping

Intervention Type OTHER

DNA extraction from blood

Interventions

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Genotyping

DNA extraction from blood

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient known to be compliant
* Age \[25-80\]
* treated with Atorvastatin, simvastatin, fluvastatin.

Exclusion Criteria

* Pregnancy
Minimum Eligible Age

25 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Saint-Luc Hospital

Brussels, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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CYPstatin001

Identifier Type: -

Identifier Source: org_study_id

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