Prone Patient Positioning in Reducing Tumor Motion and Improving Breathing Reproduction in Patients With Lung Cancer Undergoing Radiation Therapy

NCT ID: NCT01851161

Last Updated: 2015-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

23 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2015-09-30

Brief Summary

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This clinical trial studies prone patient positioning in reducing tumor motion and improving breathing reproduction in patients with lung cancer undergoing radiation therapy. Prone patient positioning during radiation therapy may help kill tumor cells without harming normal tissue.

Detailed Description

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PRIMARY OBJECTIVES:

I. Quantify the three-dimensional tumor and normal tissue (thoracic and abdominal) motion, deformation and volume changes with the respiratory cycle during imaging in prone vs. supine positioning.

II. Quantify the three-dimensional tumor and normal tissue (thoracic and abdominal) motion, deformation and volume changes with the respiratory cycle and alterations thereof during a radiotherapy series.

OUTLINE:

Patients undergo one conventional computed tomography (CT) scan and one 4 dimensional CT (4D CT) scan in both supine and prone positioning before undergoing radiation therapy.

Conditions

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Lung Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Diagnostic (CT and 4D CT in supine and prone positioning)

Patients undergo conventional CT scan and 4D CT scan in both supine and prone positioning before undergoing radiation therapy.

computed tomography

Intervention Type PROCEDURE

Undergo conventional CT scan in both supine and prone positioning

4-dimensional computed tomography

Intervention Type PROCEDURE

Undergo 4D CT scan in both supine and prone positioning

radiation therapy

Intervention Type RADIATION

Undergo radiation therapy

Interventions

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computed tomography

Undergo conventional CT scan in both supine and prone positioning

Intervention Type PROCEDURE

4-dimensional computed tomography

Undergo 4D CT scan in both supine and prone positioning

Intervention Type PROCEDURE

radiation therapy

Undergo radiation therapy

Intervention Type RADIATION

Other Intervention Names

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tomography, computed 4D-CT irradiation, radiotherapy, therapy, radiation

Eligibility Criteria

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Inclusion Criteria

* Measurable disease on the planning computed tomography (CT) scan
* Patients with lung cancer visible on fluoroscopic imaging or planning CT who are scheduled to receive external beam radiation treatment will be eligible for this study

Exclusion Criteria

* Patients requiring continuous supplemental oxygen due to the requirement of spirometry during all imaging studies
* Pregnant females
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Virginia Commonwealth University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mihaela Rosu, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Virginia Commonwealth University

Locations

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Virginia Commonwealth University, Massey Cancer Center

Richmond, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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NCI-2013-00848

Identifier Type: REGISTRY

Identifier Source: secondary_id

HM12806

Identifier Type: OTHER

Identifier Source: secondary_id

MCC-12806

Identifier Type: -

Identifier Source: org_study_id

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